Arhgef7 Rho guanine nucleotide exchange factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arhgef7provided by MGI
Official Full Name: Rho guanine nucleotide exchange factorprovided by MGI
Primary source: MGI:MGI:1860493
See related: Ensembl:ENSMUSG00000031511 AllianceGenome:MGI:1860493
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PIX; Cool; Pak3bp; cool-1; p85SPR; betaPix; beta-Pix; p85Cool1; betaPix-b; betaPix-c; mKIAA0142
Summary: Enables guanyl-nucleotide exchange factor activity and protein kinase binding activity. Involved in lamellipodium assembly. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; positive regulation of GTPase activity; and positive regulation of growth hormone secretion. Located in several cellular components, including lamellipodium; postsynapse; and storage vacuole. Is expressed in several structures, including metanephros; nervous system; and retina. Orthologous to human ARHGEF7 (Rho guanine nucleotide exchange factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cerebellum adult (RPKM 15.8), whole brain E14.5 (RPKM 14.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A1.1; 8 5.73 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (11778053..11885219)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (11728001..11835219)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myosin 18Aalpha targets the guanine nucleotide exchange factor beta-Pix to the dendritic spines of cerebellar Purkinje neurons and promotes spine maturation.
Title: Myosin 18Aα targets the guanine nucleotide exchange factor β-Pix to the dendritic spines of cerebellar Purkinje neurons and promotes spine maturation.
Targeted intestinal deletion of Rho guanine nucleotide exchange factor 7, betaPIX, impairs enterocyte proliferation, villus maturation, and mucosal defenses in mice.
Title: Targeted intestinal deletion of Rho guanine nucleotide exchange factor 7, βPIX, impairs enterocyte proliferation, villus maturation, and mucosal defenses in mice.
ARHGEF7 (beta-PIX) Is Required for the Maintenance of Podocyte Architecture and Glomerular Function.
Title: ARHGEF7 (β-PIX) Is Required for the Maintenance of Podocyte Architecture and Glomerular Function.
beta-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo.
Title: β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo.
Paxillin S273 Phosphorylation Regulates Adhesion Dynamics and Cell Migration through a Common Protein Complex with PAK1 and betaPIX.
Title: Paxillin S273 Phosphorylation Regulates Adhesion Dynamics and Cell Migration through a Common Protein Complex with PAK1 and βPIX.
GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling.
Title: GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling.
These results indicate that betaPix is required for neurite morphogenesis and synapse formation, and the reduced expression of betaPix proteins results in a defect in social behavior.
Title: βPix heterozygous mice have defects in neuronal morphology and social interaction.
betaPix-knockout Mouse Embryonic Fibroblasts exhibit decreased Rac1 activity, and defects in cell spreading and platelet-derived growth factor (PDGF)-induced ruffle formation and chemotaxis.
Title: Loss of ϐPix Causes Defects in Early Embryonic Development, and Cell Spreading and PlateletDerived Growth Factor-Induced Chemotaxis in Mouse Embryonic Fibroblasts.
The authors show that Arhgef7 interacts with the GTPase TC10 that is closely related to Cdc42. Expression of active TC10 can restore the ability to extend axons in Arhgef7-deficient neurons
Title: The guanine nucleotide exchange factor Arhgef7/βPix promotes axon formation upstream of TC10.
These findings indicate that AMPK promotes the assembly of beta1Pix, 14-3-3 proteins, and Nedd4-2 into a complex that inhibits ENaC by enhancing Nedd4-2 binding to ENaC and its degradation.
Title: β(1)Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Arhgef7 (e-PCR), detects polymorphism
- UniSTS:496708

D8Mit256 (e-PCR), detects polymorphism
- UniSTS:131465

RH136434 (e-PCR)
- UniSTS:210421

U96634 (e-PCR)
- UniSTS:179707

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables gamma-tubulin binding	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
contributes_to small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in astrocyte cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in lamellipodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of microtubule nucleation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	HMP more info	PubMed
acts_upstream_of_or_within positive regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of growth hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in presynaptic actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in small GTPase-mediated signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in storage vacuole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: rho guanine nucleotide exchange factor 7

Names: PAK-interacting exchange factor beta; Pak3 binding protein; Rho guanine nucleotide exchange factor (GEF7)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113517.2 → NP_001106989.1 rho guanine nucleotide exchange factor 7 isoform a

Status: VALIDATED

Source sequence(s)

AC120785, AC126800

Consensus CDS

CCDS52480.1

UniProtKB/Swiss-Prot

Q9ES28

Related

ENSMUSP00000106534.3, ENSMUST00000110909.9

Conserved Domains (7) summary

cd12061
Location:167 → 220

SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor

cd00014
Location:3 → 107

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00160
Location:251 → 428

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01225
Location:459 → 557

PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain

pfam00169
Location:477 → 557

PH; PH domain

pfam16614
Location:613 → 711

RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

pfam16615
Location:117 → 163

RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
NM_001113518.2 → NP_001106990.1 rho guanine nucleotide exchange factor 7 isoform b

See identical proteins and their annotated locations for NP_001106990.1

Status: VALIDATED

Source sequence(s)

AC120785, AC126800

Consensus CDS

CCDS52481.1

UniProtKB/TrEMBL

D3Z0V2

Related

ENSMUSP00000096538.3, ENSMUST00000098938.9

Conserved Domains (6) summary

cd12061
Location:10 → 63

SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor

cd00160
Location:94 → 271

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01225
Location:302 → 400

PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain

pfam00169
Location:320 → 400

PH; PH domain

pfam16523
Location:616 → 702

betaPIX_CC; betaPIX coiled coil

pfam16614
Location:456 → 554

RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
NM_001372321.1 → NP_001359250.1 rho guanine nucleotide exchange factor 7 isoform d

Status: VALIDATED

Source sequence(s)

AC120785, AC126800

UniProtKB/Swiss-Prot

O08757, Q3UTS5, Q6XPA5, Q6ZQI5, Q8C750, Q91ZZ6, Q9ES27, Q9ES28

Conserved Domains (7) summary

cd12061
Location:167 → 220

SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor

cd00014
Location:3 → 107

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00160
Location:251 → 428

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01225
Location:459 → 557

PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain

pfam16523
Location:773 → 859

betaPIX_CC; betaPIX coiled coil

pfam16614
Location:613 → 711

RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

pfam16615
Location:117 → 163

RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
NM_001372322.1 → NP_001359251.1 rho guanine nucleotide exchange factor 7 isoform e

Status: VALIDATED

Source sequence(s)

AC120785, AC126800

Conserved Domains (7) summary

cd12061
Location:167 → 220

SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor

cd00014
Location:3 → 107

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00160
Location:251 → 428

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01225
Location:459 → 557

PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain

pfam16523
Location:714 → 800

betaPIX_CC; betaPIX coiled coil

pfam16614
Location:613 → 711

RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

pfam16615
Location:117 → 163

RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
NM_001372323.1 → NP_001359252.1 rho guanine nucleotide exchange factor 7 isoform f

Status: VALIDATED

Source sequence(s)

AC120785, AC126800

UniProtKB/TrEMBL

D3Z0V2

Conserved Domains (6) summary

cd12061
Location:85 → 138

SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor

cd00160
Location:169 → 346

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01225
Location:377 → 475

PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain

pfam16523
Location:632 → 718

betaPIX_CC; betaPIX coiled coil

pfam16614
Location:531 → 629

RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

pfam16615
Location:35 → 81

RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
NM_001372324.1 → NP_001359253.1 rho guanine nucleotide exchange factor 7 isoform c

Status: VALIDATED

Source sequence(s)

AC120785, AC126800

UniProtKB/TrEMBL

A0A0R4J0X8, D3Z0V2

Conserved Domains (5) summary

cd12061
Location:10 → 63

SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor

cd00160
Location:94 → 271

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01225
Location:302 → 400

PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain

pfam16523
Location:557 → 643

betaPIX_CC; betaPIX coiled coil

pfam16614
Location:456 → 554

RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
NM_001372325.1 → NP_001359254.1 rho guanine nucleotide exchange factor 7 isoform g

Status: VALIDATED

Source sequence(s)

AC120785, AC126800

UniProtKB/TrEMBL

D3Z0V2

Conserved Domains (5) summary

cd12061
Location:10 → 63

SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor

cd00160
Location:93 → 270

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01225
Location:301 → 399

PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain

pfam16523
Location:556 → 642

betaPIX_CC; betaPIX coiled coil

pfam16614
Location:455 → 553

RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
NM_001372326.1 → NP_001359255.1 rho guanine nucleotide exchange factor 7 isoform h

Status: VALIDATED

Source sequence(s)

AC120785, AC126800

UniProtKB/TrEMBL

D3Z0V2

Conserved Domains (4) summary

cd12061
Location:10 → 63

SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor

cd00160
Location:94 → 271

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01225
Location:302 → 400

PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain

pfam16614
Location:456 → 554

RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
NM_017402.5 → NP_059098.2 rho guanine nucleotide exchange factor 7 isoform c

See identical proteins and their annotated locations for NP_059098.2

Status: VALIDATED

Source sequence(s)

AC120785, AC126800

Consensus CDS

CCDS22099.1

UniProtKB/TrEMBL

A0A0R4J0X8, D3Z0V2

Related

ENSMUSP00000074399.7, ENSMUST00000074856.13

Conserved Domains (5) summary

cd12061
Location:10 → 63

SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor

cd00160
Location:94 → 271

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01225
Location:302 → 400

PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain

pfam16523
Location:557 → 643

betaPIX_CC; betaPIX coiled coil

pfam16614
Location:456 → 554

RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

11778053..11885219

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036154166.1 → XP_036010059.1 rho guanine nucleotide exchange factor 7 isoform X1

Conserved Domains (7) summary

cd12061
Location:224 → 277

SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor

cd00160
Location:308 → 485

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01225
Location:516 → 614

PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain

pfam16614
Location:670 → 768

RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

pfam16523
Location:830 → 916

betaPIX_CC; betaPIX coiled coil

pfam16615
Location:174 → 220

RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

cl00030
Location:3 → 172

CH_SF; calponin homology (CH) domain superfamily
XM_036154167.1 → XP_036010060.1 rho guanine nucleotide exchange factor 7 isoform X2

Conserved Domains (7) summary

cd12061
Location:224 → 277

SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor

cd00160
Location:308 → 485

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01225
Location:516 → 614

PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain

pfam16614
Location:670 → 768

RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

pfam16523
Location:771 → 857

betaPIX_CC; betaPIX coiled coil

pfam16615
Location:174 → 220

RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

cl00030
Location:3 → 172

CH_SF; calponin homology (CH) domain superfamily
XM_036154168.1 → XP_036010061.1 rho guanine nucleotide exchange factor 7 isoform X3

Conserved Domains (7) summary

cd12061
Location:224 → 277

SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor

cd00160
Location:308 → 485

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01225
Location:516 → 614

PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain

pfam16614
Location:633 → 693

RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

pfam16523
Location:755 → 841

betaPIX_CC; betaPIX coiled coil

pfam16615
Location:174 → 220

RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

cl00030
Location:3 → 172

CH_SF; calponin homology (CH) domain superfamily
XM_036154170.1 → XP_036010063.1 rho guanine nucleotide exchange factor 7 isoform X5

Conserved Domains (7) summary

cd12061
Location:224 → 277

SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor

cd00160
Location:308 → 485

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01225
Location:516 → 614

PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain

pfam16614
Location:633 → 693

RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

pfam16523
Location:696 → 782

betaPIX_CC; betaPIX coiled coil

pfam16615
Location:174 → 220

RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

cl00030
Location:3 → 172

CH_SF; calponin homology (CH) domain superfamily
XM_036154169.1 → XP_036010062.1 rho guanine nucleotide exchange factor 7 isoform X4

Conserved Domains (7) summary

cd12061
Location:138 → 191

SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor

cd00160
Location:222 → 399

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01225
Location:430 → 528

PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain

pfam16614
Location:584 → 682

RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

pfam16523
Location:744 → 830

betaPIX_CC; betaPIX coiled coil

pfam16615
Location:88 → 134

RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7

cl00030
Location:3 → 86

CH_SF; calponin homology (CH) domain superfamily
XM_030243677.2 → XP_030099537.1 rho guanine nucleotide exchange factor 7 isoform X9

Conserved Domains (4) summary

cd00160
Location:1 → 134

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01225
Location:165 → 263

PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain

pfam16523
Location:479 → 565

betaPIX_CC; betaPIX coiled coil

pfam16614
Location:319 → 417

RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
XM_036154173.1 → XP_036010066.1 rho guanine nucleotide exchange factor 7 isoform X8

UniProtKB/TrEMBL

D3Z0V2

Conserved Domains (5) summary

cd12061
Location:10 → 63

SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor

cd00160
Location:94 → 271

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01225
Location:302 → 400

PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain

pfam16614
Location:419 → 479

RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

pfam16523
Location:482 → 568

betaPIX_CC; betaPIX coiled coil
XM_036154175.1 → XP_036010068.1 rho guanine nucleotide exchange factor 7 isoform X11

Conserved Domains (3) summary

cd00160
Location:1 → 134

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01225
Location:165 → 263

PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain

pfam16614
Location:319 → 417

RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7
XM_036154174.1 → XP_036010067.1 rho guanine nucleotide exchange factor 7 isoform X10

Conserved Domains (4) summary

cd00160
Location:1 → 134

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01225
Location:165 → 263

PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain

pfam16614
Location:319 → 417

RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

pfam16523
Location:420 → 506

betaPIX_CC; betaPIX coiled coil
XM_006508845.5 → XP_006508908.1 rho guanine nucleotide exchange factor 7 isoform X6

UniProtKB/TrEMBL

D3Z0V2

Conserved Domains (6) summary

cd12061
Location:85 → 138

SH3_betaPIX; Src Homology 3 domain of beta-Pak Interactive eXchange factor

cd00160
Location:169 → 346

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01225
Location:377 → 475

PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain

pfam16523
Location:691 → 777

betaPIX_CC; betaPIX coiled coil

pfam16614
Location:531 → 629

RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

pfam16615
Location:35 → 81

RhoGEF67_u1; Unstructured region one on RhoGEF 6 and 7
XM_036154171.1 → XP_036010064.1 rho guanine nucleotide exchange factor 7 isoform X7

UniProtKB/TrEMBL

D3Z0V2

Conserved Domains (4) summary

cd00160
Location:17 → 192

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd01225
Location:223 → 321

PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain

pfam16614
Location:377 → 475

RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

pfam16523
Location:537 → 623

betaPIX_CC; betaPIX coiled coil