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    Pglyrp1 peptidoglycan recognition protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 21946, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pglyrp1provided by MGI
    Official Full Name
    peptidoglycan recognition protein 1provided by MGI
    Primary source
    MGI:MGI:1345092
    See related
    Ensembl:ENSMUSG00000030413
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PG; Tag; Tas; PGRP; Tag7; Tnfs; Tasg7; PGRP-S; Pglyrp; Tnfsf3l
    Expression
    Biased expression in colon adult (RPKM 543.4), duodenum adult (RPKM 351.9) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pglyrp1 in Genome Data Viewer
    Location:
    7; 7 A3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (18618615..18624363)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (18884690..18890438)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (19470039..19475787)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein K pseudogene Neighboring gene MHC I like leukocyte 2 Neighboring gene coiled-coil domain containing 61 Neighboring gene NOVA alternative splicing regulator 2 Neighboring gene predicted gene, 38952

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetylmuramoyl-L-alanine amidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables peptidoglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidoglycan immune receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables peptidoglycan immune receptor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within biological process involved in interaction with host IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in detection of bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in detection of bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in killing of cells of other organism ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of interferon-gamma production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of natural killer cell differentiation involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidoglycan catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    peptidoglycan recognition protein 1
    Names
    cytokine tag7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009402.2NP_033428.1  peptidoglycan recognition protein 1 precursor

      See identical proteins and their annotated locations for NP_033428.1

      Status: PROVISIONAL

      Source sequence(s)
      AC153651
      Consensus CDS
      CCDS20881.1
      UniProtKB/Swiss-Prot
      O88593
      UniProtKB/TrEMBL
      Q4FK86
      Related
      ENSMUSP00000032573.7, ENSMUST00000032573.8
      Conserved Domains (1) summary
      smart00701
      Location:20160
      PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      18618615..18624363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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