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    Sh2d1a SH2 domain containing 1A [ Mus musculus (house mouse) ]

    Gene ID: 20400, updated on 29-Jun-2021

    Summary

    Official Symbol
    Sh2d1aprovided by MGI
    Official Full Name
    SH2 domain containing 1Aprovided by MGI
    Primary source
    MGI:MGI:1328352
    See related
    Ensembl:ENSMUSG00000005696
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SAP; Gm686
    Expression
    Restricted expression toward thymus adult (RPKM 26.6) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Sh2d1a in Genome Data Viewer
    Location:
    X; X A4
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (41591442..41610974)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (42502565..42522097)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (39855785..39875252)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA B230118I11 gene Neighboring gene TEX13 family member D Neighboring gene teneurin transmembrane protein 1 Neighboring gene predicted gene, 23705 Neighboring gene predicted gene, 46667

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    SH2 domain-containing protein 1A
    Names
    Duncan disease homolog
    SH2 domain protein 1A
    T-cell signal transduction molecule SAP
    signaling lymphocytic activation molecule-associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313688.1NP_001300617.1  SH2 domain-containing protein 1A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF097632, AL831716, KF811030
      UniProtKB/Swiss-Prot
      O88890
      UniProtKB/TrEMBL
      W0BZ77
      Conserved Domains (1) summary
      cl15255
      Location:2122
      SH2; Src homology 2 (SH2) domain
    2. NM_001313689.1NP_001300618.1  SH2 domain-containing protein 1A isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 3' end of the first exon and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AF097632, AL831716
      Consensus CDS
      CCDS85770.1
      UniProtKB/Swiss-Prot
      O88890
      Related
      ENSMUSP00000110722.2, ENSMUST00000115070.8
      Conserved Domains (1) summary
      cl15255
      Location:2101
      SH2; Src homology 2 (SH2) domain
    3. NM_001313691.1NP_001300620.1  SH2 domain-containing protein 1A isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate first exon and lacks an internal exon compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AF097632, BF019627
      UniProtKB/Swiss-Prot
      O88890
      UniProtKB/TrEMBL
      B2RWI0
      Conserved Domains (1) summary
      cl15255
      Location:159
      SH2; Src homology 2 (SH2) domain
    4. NM_011364.4NP_035494.1  SH2 domain-containing protein 1A isoform 2

      See identical proteins and their annotated locations for NP_035494.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AF097632, AK040076, AL831716
      Consensus CDS
      CCDS30099.1
      UniProtKB/Swiss-Prot
      O88890
      UniProtKB/TrEMBL
      Q544F1
      Related
      ENSMUSP00000005839.5, ENSMUST00000005839.11
      Conserved Domains (1) summary
      cd10400
      Location:2104
      SH2_SAP1a; Src homology 2 (SH2) domain found in SLAM-associated protein (SAP) 1a

    RNA

    1. NR_132588.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks two alternate exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF097632, AK040076, AL831716, BF721340

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      41591442..41610974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318440.1XP_017173929.1  SH2 domain-containing protein 1A isoform X1

      UniProtKB/TrEMBL
      B2RWI0
      Conserved Domains (1) summary
      cl15255
      Location:159
      SH2; Src homology 2 (SH2) domain
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