Serpinb11 serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serpinb11provided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 11provided by MGI
Primary source: MGI:MGI:1914207
See related: Ensembl:ENSMUSG00000026327 AllianceGenome:MGI:1914207
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310046M08Rik
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Is expressed in several structures, including gut; hemolymphoid system; liver; nose; and reproductive system. Orthologous to human SERPINB11 (serpin family B member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 1 E2.1; 1 50.34 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (107290044..107308205)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (107362314..107380475)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The spatiotemporal expression and localization implicates a potential role for SerpinB11 in the process of mouse spermatogenesis and apoptosis
Title: The spatiotemporal expression and localization implicates a potential role for SerpinB11 in the process of mouse spermatogenesis and apoptosis.
SerpinB11 is probably involved in embryo implantation and decidualization.
Title: Expression and localization of SerpinB11 in mouse uteri during peri-implantation and the estrous cycle.
SERPINB11 is a new noninhibitory intracellular serpin
Title: SERPINB11 is a new noninhibitory intracellular serpin. Common single nucleotide polymorphisms in the scaffold impair conformational change.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

AU015399 (e-PCR)
- UniSTS:207198

Serpinb11 (e-PCR), detects polymorphism
- UniSTS:507379

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serpin B11

Names: serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025867.2 → NP_080143.1 serpin B11

See identical proteins and their annotated locations for NP_080143.1

Status: VALIDATED

Source sequence(s)

AK009855

Consensus CDS

CCDS15218.1

UniProtKB/Swiss-Prot

Q91Z12, Q9CQV3

Related

ENSMUSP00000027566.3, ENSMUST00000027566.3

Conserved Domains (1) summary

cl00137
Location:4 → 388

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...