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    Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 20493, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Slc10a1provided by MGI
    Official Full Name
    solute carrier family 10 (sodium/bile acid cotransporter family), member 1provided by MGI
    Primary source
    MGI:MGI:97379
    See related
    Ensembl:ENSMUSG00000021135 AllianceGenome:MGI:97379
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ntcp
    Summary
    Predicted to enable bile acid:sodium symporter activity. Predicted to be involved in bile acid and bile salt transport. Predicted to act upstream of or within sodium ion transport. Located in membrane. Orthologous to human SLC10A1 (solute carrier family 10 member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 329.4) and liver E18 (RPKM 155.9) See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 D1; 12 37.21 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (80999959..81015479, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (80953185..80968705, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4033 Neighboring gene STARR-positive B cell enhancer ABC_E5338 Neighboring gene predicted gene, 20337 Neighboring gene serine and arginine-rich splicing factor 5 Neighboring gene STARR-positive B cell enhancer mm9_chr12:82083313-82083614 Neighboring gene SPARC related modular calcium binding 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:82164637-82164838 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene microRNA 3067

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. NTCP Deficiency Affects the Levels of Circulating Bile Acids and Induces Osteoporosis. Yang F, et al. Front Endocrinol (Lausanne), 2022. PMID 35937832, Free PMC Article
    2. Increased sulfation of bile acids in mice and human subjects with sodium taurocholate cotransporting polypeptide deficiency. Mao F, et al. J Biol Chem, 2019 Aug 2. PMID 31201272, Free PMC Article
    3. Role of the Bile Acid Transporter SLC10A1 in Liver Targeting of the Lipid-Lowering Thyroid Hormone Analog Eprotirome. Kersseboom S, et al. Endocrinology, 2017 Oct 1. PMID 28938430
    4. Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice. Slijepcevic D, et al. Hepatology, 2015 Jul. PMID 25641256, Free PMC Article
    5. Molecular determinants of hepatitis B and D virus entry restriction in mouse sodium taurocholate cotransporting polypeptide. Yan H, et al. J Virol, 2013 Jul. PMID 23678176, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sodium(+)/taurocholate cotransporting polypeptide as target therapy for liver fibrosis.
      Title: Sodium(+)/taurocholate cotransporting polypeptide as target therapy for liver fibrosis.
    2. NTCP Deficiency Causes Gallbladder Abnormalities in Mice and Human Beings.
      Title: NTCP Deficiency Causes Gallbladder Abnormalities in Mice and Human Beings.
    3. Tanshinone IIA prevents rifampicin-induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2.
      Title: Tanshinone IIA prevents rifampicin-induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2.
    4. NTCP deficiency in mice protects against obesity and hepatosteatosis.
      Title: NTCP deficiency in mice protects against obesity and hepatosteatosis.
    5. Slc10a1 (-/-) mice alters inhibition of bile acid (BA) synthesis, enhancement of BA detoxification, BA transport and taurolithocholic acid 3-sulfate, significantly increased.
      Title: Increased sulfation of bile acids in mice and human subjects with sodium taurocholate cotransporting polypeptide deficiency.
    6. NTCP and OATP isoforms cooperatively form a stable bile acid uptake machinery in mice, whereas NTCP is predominant in humans.
      Title: Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice.
    7. Isoniazid/rifampicin administration significantly down-regulated the expression of hepatic bile acids transporters Ntcp and Bsep in liver.
      Title: The inhibition of hepatic bile acids transporters Ntcp and Bsep is involved in the pathogenesis of isoniazid/rifampicin-induced hepatotoxicity.
    8. Ntcp plasma membrane localization is regulated by hyperosmolarity and tauroursodeoxycholate
      Title: Regulation of plasma membrane localization of the Na+-taurocholate cotransporting polypeptide (Ntcp) by hyperosmolarity and tauroursodeoxycholate.
    9. central role in hepatic uptake of conjugated bile acids and hepatitis B virus preS1/Myrcludex B binding
      Title: Impaired uptake of conjugated bile acids and hepatitis b virus pres1-binding in na(+) -taurocholate cotransporting polypeptide knockout mice.
    10. mNTCP was found to be unable to support either HBV or HDV infection, although it can bind to pre-S1 of HBV L protein and is functional in transporting substrate taurocholate.
      Title: Molecular determinants of hepatitis B and D virus entry restriction in mouse sodium taurocholate cotransporting polypeptide.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables bile acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables bile acid:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bile acid:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bile acid and bile salt transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hepatic sodium/bile acid cotransporter
    Names
    Na(+)/bile acid cotransporter
    Na(+)/taurocholate transport protein
    bile acid cotransporting polypeptide
    sodium bile acid cotransporting polypeptide
    sodium-taurocholate cotransporting polypeptide

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177561.1 → NP_001171032.1  hepatic sodium/bile acid cotransporter isoform 1

      See identical proteins and their annotated locations for NP_001171032.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AC125092
      Consensus CDS
      CCDS49101.1
      UniProtKB/Swiss-Prot
      O08705, O35940, Q52L86
      Related
      ENSMUSP00000093229.5, ENSMUST00000095572.5
      Conserved Domains (1) summary
      TIGR00841
      Location:22 → 311
      bass; bile acid transporter

    2. NM_001361972.1 → NP_001348901.1  hepatic sodium/bile acid cotransporter isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AC125092
      Consensus CDS
      CCDS49101.1
      UniProtKB/Swiss-Prot
      O08705, O35940, Q52L86
      Related
      ENSMUSP00000151555.2, ENSMUST00000218162.2
      Conserved Domains (1) summary
      TIGR00841
      Location:22 → 311
      bass; bile acid transporter

    3. NM_011387.2 → NP_035517.1  hepatic sodium/bile acid cotransporter isoform 2

      See identical proteins and their annotated locations for NP_035517.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate segment in the 3' coding region that results in a frameshift and early stop codon compare to variant 1. The resulting protein (isoform 2) has a shorter, distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC125092
      Consensus CDS
      CCDS88362.1
      UniProtKB/TrEMBL
      A0A8V5KH54
      Related
      ENSMUSP00000151215.2, ENSMUST00000218342.2
      Conserved Domains (1) summary
      TIGR00841
      Location:22 → 311
      bass; bile acid transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      80999959..81015479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08705.1 GenPept UniProtKB/Swiss-Prot:O08705

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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