Thbs2 thrombospondin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Thbs2provided by MGI
Official Full Name: thrombospondin 2provided by MGI
Primary source: MGI:MGI:98738
See related: Ensembl:ENSMUSG00000023885 AllianceGenome:MGI:98738
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TSP2; Thbs-2
Summary: Predicted to enable calcium ion binding activity and heparin binding activity. Involved in negative regulation of angiogenesis. Located in basement membrane. Is expressed in several structures, including genitourinary system; jaw; mesothelium; respiratory system; and skin. Orthologous to human THBS2 (thrombospondin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 44.4), limb E14.5 (RPKM 28.8) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A2; 17 8.95 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (14885762..14914524, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (14665500..14694262, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of thrombospondin-2 alleviates intimal hyperplasia in mice by modulating vascular smooth muscle cell proliferation and migration.
Title: Deficiency of thrombospondin-2 alleviates intimal hyperplasia in mice by modulating vascular smooth muscle cell proliferation and migration.
Contribution of Thrombospondin-1 and -2 to Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome.
Title: Contribution of Thrombospondin-1 and -2 to Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome.
Compound deletion of thrombospondin-1 and -2 results in a skeletal phenotype not predicted by the single gene knockouts.
Title: Compound deletion of thrombospondin-1 and -2 results in a skeletal phenotype not predicted by the single gene knockouts.
Thrombospondin-2 spatiotemporal expression in skeletal fractures.
Title: Thrombospondin-2 spatiotemporal expression in skeletal fractures.
Inhibiting role of long non-coding RNA LINC01197 in inflammation in rheumatoid arthritis through the microRNA-150/THBS2 axis.
Title: Inhibiting role of long non-coding RNA LINC01197 in inflammation in rheumatoid arthritis through the microRNA-150/THBS2 axis.
TSP1 and TSP2 deficiencies affect LOX protein distribution in the femoral diaphysis and pro-peptide removal in marrow-derived mesenchymal stem cells in vitro.
Title: TSP1 and TSP2 deficiencies affect LOX protein distribution in the femoral diaphysis and pro-peptide removal in marrow-derived mesenchymal stem cells in vitro.
Findings demonstrate a novel link between TSP2, LOX, and miR-29 that is regulated by the presence or absence of TSP2 in the extracellular environment, forming a feedback loop between cells and its extracellular matrix substrate.
Title: Thrombospondin-2 regulates extracellular matrix production, LOX levels, and cross-linking via downregulation of miR-29.
Though the TSP2-deficient mice developed obesity and hyperglycemia comparable with diabetic control mice, they exhibited significantly improved healing, characterized by accelerated reepithelialization and increased granulation tissue formation, fibroblast migration, and blood vessel maturation.
Title: Elevated Thrombospondin 2 Contributes to Delayed Wound Healing in Diabetes.
THBS2 protein was confirmed to be enhanced in Liver Fibrosis rodent models, which could promote hepatic stellate cell activation and proliferation and facilitate NOTCH1/JAG1 expression in hepatic stellate cells.
Title: Multitranscriptome analyses reveal prioritized genes specifically associated with liver fibrosis progression independent of etiology.
We observed an upregulation in the expression of TSP1 and TSP2 mRNA in control mouse cochleae following noise exposure. afferent synaptic counts and auditory brainstem responses (ABRs) in noise-exposed TSP1 and TSP2 knockout (-/-) mice exhibited a worst recovery than controls. TSP2-/- mice showed greater susceptibility to noise-induced hearing loss at mid and high frequencies.
Title: TSP1 and TSP2 Have Unique and Overlapping Roles in Protecting against Noise-Induced Auditory Synaptopathy.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC117612P1 (e-PCR)
- UniSTS:270338

L07803 (e-PCR)
- UniSTS:160620

Thbs2 (e-PCR), detects polymorphism
- UniSTS:532692

L07803 (e-PCR)
- UniSTS:186088

Thbs2 (e-PCR), detects polymorphism
- UniSTS:144619

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in platelet alpha granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thrombospondin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011581.3 → NP_035711.2 thrombospondin-2 precursor

See identical proteins and their annotated locations for NP_035711.2

Status: VALIDATED

Source sequence(s)

AK132508, AK142552, AK165881, CJ049934

Consensus CDS

CCDS49958.1

UniProtKB/Swiss-Prot

Q03350, Q8CG21

UniProtKB/TrEMBL

Q7TMT3

Related

ENSMUSP00000128308.2, ENSMUST00000170872.3

Conserved Domains (10) summary

smart00209
Location:497 → 549

TSP1; Thrombospondin type 1 repeats

smart00210
Location:21 → 213

TSPN; Thrombospondin N-terminal -like domains

sd00001
Location:847 → 884

TSP3; TSP3 repeat_long [structural motif]

sd00002
Location:789 → 823

TSP3; TSP3 repeat_long [structural motif]

sd00003
Location:693 → 728

TSP3_1C; TSP3 repeat_1C [structural motif]

pfam00090
Location:385 → 430

TSP_1; Thrombospondin type 1 domain

pfam00093
Location:320 → 374

VWC; von Willebrand factor type C domain

pfam02412
Location:848 → 884

TSP_3; Thrombospondin type 3 repeat

pfam05735
Location:974 → 1171

TSP_C; Thrombospondin C-terminal region

pfam12947
Location:652 → 691

EGF_3; EGF domain