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    C1galt1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 [ Mus musculus (house mouse) ]

    Gene ID: 94192, updated on 21-Apr-2024

    Summary

    Official Symbol
    C1galt1provided by MGI
    Official Full Name
    core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1provided by MGI
    Primary source
    MGI:MGI:2151071
    See related
    Ensembl:ENSMUSG00000042460 AllianceGenome:MGI:2151071
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    T-synthase; 2210410E06Rik
    Summary
    Predicted to enable glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. Acts upstream of or within angiogenesis; intestinal epithelial cell development; and protein O-linked glycosylation. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human C1GALT1 (core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 10.0), colon adult (RPKM 6.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    6 A1; 6 3.37 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (7845224..7872042)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (7845224..7872042)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35194 Neighboring gene STARR-positive B cell enhancer ABC_E1063 Neighboring gene STARR-positive B cell enhancer ABC_E3643 Neighboring gene polymerase (RNA) I polypeptide D pseudogene Neighboring gene predicted gene, 35246 Neighboring gene STARR-seq mESC enhancer starr_15106 Neighboring gene RNA binding protein with serine rich domain 1, pseudogene Neighboring gene predicted gene, 35446

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (5)  1 citation
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (5) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in O-glycan processing, core 1 IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within O-glycan processing, core 1 ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within intestinal epithelial cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein O-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
    Names
    T-syn
    core 1 O-glycan T-synthase
    core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1
    core 1 beta1,3-galactosyltransferase 1
    core 1 beta3-Gal-T
    core 1 beta3-Gal-T1
    core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1
    NP_443719.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_052993.3NP_443719.3  glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

      See identical proteins and their annotated locations for NP_443719.3

      Status: VALIDATED

      Source sequence(s)
      AI060759, AW824923, BB625752, BC064767, BF471960, BG077752
      Consensus CDS
      CCDS19908.1
      UniProtKB/Swiss-Prot
      Q6P218, Q8R0Z7, Q9JJ06
      Related
      ENSMUSP00000047931.5, ENSMUST00000040159.6
      Conserved Domains (1) summary
      cl21608
      Location:107248
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      7845224..7872042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)