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    Copz1 coatomer protein complex, subunit zeta 1 [ Mus musculus (house mouse) ]

    Gene ID: 56447, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Copz1provided by MGI
    Official Full Name
    coatomer protein complex, subunit zeta 1provided by MGI
    Primary source
    MGI:MGI:1929063
    See related
    Ensembl:ENSMUSG00000060992 AllianceGenome:MGI:1929063
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D4Ertd360e; 5930435A22Rik
    Summary
    Acts upstream of or within toxin transport. Predicted to be located in Golgi apparatus; cytoplasmic vesicle; and membrane. Predicted to be part of COPI vesicle coat. Orthologous to human COPZ1 (COPI coat complex subunit zeta 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 79.6), liver E14.5 (RPKM 69.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 F3; 15 58.74 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (103181261..103208295)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (103272888..103299865)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 Neighboring gene STARR-seq mESC enhancer starr_39872 Neighboring gene nuclear factor, erythroid derived 2 Neighboring gene STARR-positive B cell enhancer ABC_E81 Neighboring gene microRNA 148b Neighboring gene predicted gene, 41406 Neighboring gene STARR-positive B cell enhancer ABC_E3160 Neighboring gene STARR-positive B cell enhancer ABC_E1487 Neighboring gene G protein-coupled receptor 84 Neighboring gene zinc finger protein 385A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Differential localization of coatomer complex isoforms within the Golgi apparatus. Moelleken J, et al. Proc Natl Acad Sci U S A, 2007 Mar 13. PMID 17360540
    2. CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Slater LH, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23716698, Free PMC Article
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of differential localization of coatomer complex isoforms within the Golgi apparatus
      Title: Differential localization of coatomer complex isoforms within the Golgi apparatus.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118060

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPI vesicle coat ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coatomer subunit zeta-1
    Names
    nonclathrin coat protein zeta1-COP
    zeta-1 COP
    zeta-1-coat protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357748.1 → NP_001344677.1  coatomer subunit zeta-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC164069
      UniProtKB/TrEMBL
      Q8R3M1
      Related
      ENSMUSP00000155674.2, ENSMUST00000230893.2
      Conserved Domains (1) summary
      cd14829
      Location:14 → 145
      Zeta-COP; zeta subunit of the F-COPI complex

    2. NM_019817.2 → NP_062791.1  coatomer subunit zeta-1 isoform 2

      See identical proteins and their annotated locations for NP_062791.1

      Status: VALIDATED

      Source sequence(s)
      AC164069
      Consensus CDS
      CCDS27901.1
      UniProtKB/Swiss-Prot
      P61924
      UniProtKB/TrEMBL
      Q542M2, Q8R3M1
      Related
      ENSMUSP00000097738.4, ENSMUST00000100162.5
      Conserved Domains (1) summary
      cd14829
      Location:14 → 145
      Zeta-COP; zeta subunit of the F-COPI complex

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      103181261..103208295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004938859.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61924.1 GenPept UniProtKB/Swiss-Prot:P61924

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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