Fcgr2b Fc receptor, IgG, low affinity IIb [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fcgr2bprovided by MGI
Official Full Name: Fc receptor, IgG, low affinity IIbprovided by MGI
Primary source: MGI:MGI:95499
See related: Ensembl:ENSMUSG00000026656 AllianceGenome:MGI:95499
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD32; Fcgr2; Fcr-2; Fcr-3; Ly-17; LyM-1; Lym-1; fcRII; FcgRII; Fcgr2a; Ly-m20; Fc[g]RII; F630109E10Rik
Summary: Enables IgG binding activity. Involved in several processes, including cellular response to amyloid-beta; nervous system development; and regulation of cellular response to stress. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of immune effector process; and regulation of phagocytosis. Located in cell body; dendritic spine; and external side of plasma membrane. Is integral component of membrane. Is expressed in liver and spleen. Used to study malaria and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to several human genes including FCGR2B (Fc fragment of IgG receptor IIb). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in kidney adult (RPKM 19.1), spleen adult (RPKM 16.7) and 21 other tissues See more
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Genomic context

Location:: 1 H3; 1 78.02 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (170786186..170804141, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (170960558..170976071, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FcgammaRIIB Is an Immune Checkpoint Limiting the Activity of Treg-Targeting Antibodies in the Tumor Microenvironment.
Title: FcγRIIB Is an Immune Checkpoint Limiting the Activity of Treg-Targeting Antibodies in the Tumor Microenvironment.
FcgammaRIIB modulates splenic germinal center response against immune subversion during acute influenza A virus infection.
Title: FcγRIIB modulates splenic germinal center response against immune subversion during acute influenza A virus infection.
Lipopolysaccharide Impedes Bone Repair in FcgammaRIIB-Deficient Mice.
Title: Lipopolysaccharide Impedes Bone Repair in FcγRIIB-Deficient Mice.
Liver sinusoidal endothelial cells show reduced scavenger function and downregulation of Fc gamma receptor IIb, yet maintain a preserved fenestration in the Glmpgt/gt mouse model of slowly progressing liver fibrosis.
Title: Liver sinusoidal endothelial cells show reduced scavenger function and downregulation of Fc gamma receptor IIb, yet maintain a preserved fenestration in the Glmpgt/gt mouse model of slowly progressing liver fibrosis.
C-reactive protein impairs immune response of CD8[+] T cells via FcgammaRIIb-p38MAPK-ROS axis in multiple myeloma.
Title: C-reactive protein impairs immune response of CD8(+) T cells via FcγRIIb-p38MAPK-ROS axis in multiple myeloma.
Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1.
Title: Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1.
Adenovirus-mediated Overexpression of FcgammaRIIB Attenuates Pulmonary Inflammation and Fibrosis.
Title: Adenovirus-mediated Overexpression of FcγRIIB Attenuates Pulmonary Inflammation and Fibrosis.
Two major genes associated with autoimmune arthritis, Ncf1 and Fcgr2b, additively protect mice by strengthening T cell tolerance.
Title: Two major genes associated with autoimmune arthritis, Ncf1 and Fcgr2b, additively protect mice by strengthening T cell tolerance.
FcgammaRIIB is a T cell checkpoint in antitumor immunity.
Title: FcγRIIB is a T cell checkpoint in antitumor immunity.
Anti-inflammatory activity of CD44 antibodies in murine immune thrombocytopenia is mediated by Fcgamma receptor inhibition.
Title: Anti-inflammatory activity of CD44 antibodies in murine immune thrombocytopenia is mediated by Fcγ receptor inhibition.

Submit: New GeneRIF Correction See all GeneRIFs (150)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Targeted (8) 1 citation
Endonuclease-mediated (7)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI528646 (e-PCR)
- UniSTS:165121

X04648 (e-PCR)
- UniSTS:125784

D1Dcr16 (e-PCR), detects polymorphism
- UniSTS:507569

D1Mit147 (e-PCR), detects polymorphism
- UniSTS:128484

D1Mit148 (e-PCR), detects polymorphism
- UniSTS:128485

Fcgr2b (e-PCR), detects polymorphism
- UniSTS:143083

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables IgG binding	IBA Inferred from Biological aspect of Ancestor more info
enables IgG binding	IDA Inferred from Direct Assay more info	PubMed
enables IgG binding	ISO Inferred from Sequence Orthology more info
enables IgG receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables immunoglobulin binding	ISO Inferred from Sequence Orthology more info
enables low-affinity IgG receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Fc receptor-mediated immune complex endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in antibody-dependent cellular cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amyloid-beta	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to molecule of bacterial origin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebellum development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
acts_upstream_of establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune complex clearance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immunoglobulin mediated immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within mast cell activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of acute inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of humoral immune response mediated by circulating immunoglobulin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of immunoglobulin production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-10 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neutrophil apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of type I hypersensitivity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phagocytosis, engulfment	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of phagocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of long-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: low affinity immunoglobulin gamma Fc region receptor II-b

Names: Fc gamma RIIB; Fc-gamma-RII; FcgammaRIIB; fc gamma receptor IIB; fc-gamma RII; fc-gamma-RIIB; igG Fc receptor II beta; low affinity immunoglobulin gamma Fc region receptor II; lymphocyte antigen 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077189.2 → NP_001070657.1 low affinity immunoglobulin gamma Fc region receptor II-b isoform 1 precursor

See identical proteins and their annotated locations for NP_001070657.1

Status: VALIDATED

Source sequence(s)

AC115959

Consensus CDS

CCDS35770.1

UniProtKB/Swiss-Prot

P08101, P08102, P12316, P97917, Q60938, Q60939, Q60940, Q61170, Q61558

UniProtKB/TrEMBL

A0A0B4J1E6

Related

ENSMUSP00000027966.8, ENSMUST00000027966.14

Conserved Domains (3) summary

cd05753
Location:128 → 210

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:134 → 210

IG_like; Immunoglobulin like

cl11960
Location:46 → 124

Ig; Immunoglobulin domain
NM_001419005.1 → NP_001405934.1 low affinity immunoglobulin gamma Fc region receptor II-b isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC115959

UniProtKB/TrEMBL

A0A0B4J1E6

Related

ENSMUSP00000137669.2, ENSMUST00000159969.8
NM_001419006.1 → NP_001405935.1 low affinity immunoglobulin gamma Fc region receptor II-b isoform 3

Status: VALIDATED

Source sequence(s)

AC115959
NM_001419007.1 → NP_001405936.1 low affinity immunoglobulin gamma Fc region receptor II-b isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AC115959

UniProtKB/TrEMBL

E9Q415

Related

ENSMUSP00000123774.2, ENSMUST00000159688.2
NM_001419008.1 → NP_001405937.1 low affinity immunoglobulin gamma Fc region receptor II-b isoform 5

Status: VALIDATED

Source sequence(s)

AC115959
NM_001419009.1 → NP_001405938.1 low affinity immunoglobulin gamma Fc region receptor II-b isoform 6

Status: VALIDATED

Source sequence(s)

AC115959
NM_001419010.1 → NP_001405939.1 low affinity immunoglobulin gamma Fc region receptor II-b isoform 7 precursor

Status: VALIDATED

Source sequence(s)

AC115959
NM_001419011.1 → NP_001405940.1 low affinity immunoglobulin gamma Fc region receptor II-b isoform 8

Status: VALIDATED

Source sequence(s)

AC115959
NM_010187.3 → NP_034317.1 low affinity immunoglobulin gamma Fc region receptor II-b isoform 2 precursor

See identical proteins and their annotated locations for NP_034317.1

Status: VALIDATED

Source sequence(s)

AC115959

Consensus CDS

CCDS35769.1

UniProtKB/Swiss-Prot

P08101, P08102, P12316, P97917, Q60938, Q60939, Q60940, Q61170, Q61558

UniProtKB/TrEMBL

A0A0B4J1G1

Related

ENSMUSP00000079882.6, ENSMUST00000081103.12

Conserved Domains (2) summary

smart00410
Location:134 → 210

IG_like; Immunoglobulin like

cl11960
Location:128 → 210

Ig; Immunoglobulin domain