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    Tmub2 transmembrane and ubiquitin-like domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 72053, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Tmub2provided by MGI
    Official Full Name
    transmembrane and ubiquitin-like domain containing 2provided by MGI
    Primary source
    MGI:MGI:1919303
    See related
    Ensembl:ENSMUSG00000034757 AllianceGenome:MGI:1919303
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010008E23Rik
    Summary
    This gene encodes a predicted multi-pass membrane protein that features a C-terminal ubiquitin-related domain. This gene may be expressed in cone photoreceptors in the retina. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
    Expression
    Ubiquitous expression in ovary adult (RPKM 29.9), large intestine adult (RPKM 19.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    11 D; 11 66.29 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102175777..102180253)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102284951..102289427)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E911 Neighboring gene homologous recombination factor with OB-fold Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102128926-102129035 Neighboring gene ankyrin repeat and SOCS box-containing 16 Neighboring gene STARR-positive B cell enhancer ABC_E1432 Neighboring gene ataxin 7-like 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:102156604-102156807 Neighboring gene STARR-positive B cell enhancer ABC_E469 Neighboring gene predicted gene, 33851 Neighboring gene STARR-positive B cell enhancer ABC_E5281 Neighboring gene upstream binding transcription factor, RNA polymerase I

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. Corbo JC, et al. PLoS Genet, 2005 Aug. PMID 16110338, Free PMC Article
    2. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane and ubiquitin-like domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302505.2 → NP_001289434.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001289434.1

      Status: VALIDATED

      Source sequence(s)
      AL954730
      Consensus CDS
      CCDS25494.1
      UniProtKB/Swiss-Prot
      A2AWT1, Q3V209, Q8K0X0, Q91YQ0, Q9D8C5
      UniProtKB/TrEMBL
      G8JL73
      Related
      ENSMUSP00000116327.2, ENSMUST00000156326.2
      Conserved Domains (2) summary
      smart00213
      Location:173 → 240
      UBQ; Ubiquitin homologues
      pfam00240
      Location:191 → 244
      ubiquitin; Ubiquitin family

    2. NM_001302506.2 → NP_001289435.2  transmembrane and ubiquitin-like domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL954730
      UniProtKB/TrEMBL
      G8JL73
      Conserved Domains (1) summary
      cd17132
      Location:152 → 222
      Ubl_TMUB2; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2)

    3. NM_028076.4 → NP_082352.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_082352.1

      Status: VALIDATED

      Source sequence(s)
      AL954730
      Consensus CDS
      CCDS25494.1
      UniProtKB/Swiss-Prot
      A2AWT1, Q3V209, Q8K0X0, Q91YQ0, Q9D8C5
      UniProtKB/TrEMBL
      G8JL73
      Related
      ENSMUSP00000047600.7, ENSMUST00000036376.13
      Conserved Domains (2) summary
      smart00213
      Location:173 → 240
      UBQ; Ubiquitin homologues
      pfam00240
      Location:191 → 244
      ubiquitin; Ubiquitin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      102175777..102180253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V209.1 GenPept UniProtKB/Swiss-Prot:Q3V209

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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