Treml1 triggering receptor expressed on myeloid cells-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Treml1provided by MGI
Official Full Name: triggering receptor expressed on myeloid cells-like 1provided by MGI
Primary source: MGI:MGI:1918576
See related: Ensembl:ENSMUSG00000023993 AllianceGenome:MGI:1918576
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TLT-1; 5430401J17Rik
Summary: Predicted to enable transmembrane signaling receptor activity. Acts upstream of or within platelet activation. Located in cell surface and platelet alpha granule. Is expressed in liver lobe and testis. Orthologous to human TREML1 (triggering receptor expressed on myeloid cells like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 13.6), liver E14.5 (RPKM 10.2) and 6 other tissues See more
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Genomic context

Location:: 17 C; 17 23.99 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (48666944..48674204)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (48359916..48367176)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased level of TREM like Transcript 1 (TLT-1) is associated with prematurity and promotes the in-utero inflammatory response to maternal lipopolysaccharide (LPS) exposure.
Title: Decreased level of TREM like Transcript 1 (TLT-1) is associated with prematurity and promotes the in-utero inflammatory response to maternal lipopolysaccharide (LPS) exposure.
Soluble TREM-like Transcript-1 Acts as a Damage-Associated Molecular Pattern through the TLR4/MD2 Pathway Contributing to Immune Dysregulation during Sepsis.
Title: Soluble TREM-like Transcript-1 Acts as a Damage-Associated Molecular Pattern through the TLR4/MD2 Pathway Contributing to Immune Dysregulation during Sepsis.
high levels in atherosclerotic apoE-/- mice
Title: Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease.
findings suggest that TLT-1 uses fibrinogen to govern the transition between inflammation and hemostasis and facilitate controlled leukocyte transmigration during the progression of ARDS.
Title: Platelet-derived TLT-1 is a prognostic indicator in ALI/ARDS and prevents tissue damage in the lungs in a mouse model.
TREM-like transcript 1: a more sensitive marker of platelet activation than P-selectin in humans and mice.
Title: TREM-like transcript 1: a more sensitive marker of platelet activation than P-selectin in humans and mice.
TLT-1s, alternative transcripts of triggering receptor expressed on myeloid cell-like transcript-1 (TLT-1), Inhibits the triggering receptor expressed on myeloid cell-2 (TREM-2)-mediated signaling pathway during osteoclastogenesis.
Title: TLT-1s, alternative transcripts of triggering receptor expressed on myeloid cell-like transcript-1 (TLT-1), Inhibits the triggering receptor expressed on myeloid cell-2 (TREM-2)-mediated signaling pathway during osteoclastogenesis.
TLT-1 plays a protective role during inflammation by dampening the inflammatory response and facilitating platelet aggregation at sites of vascular injury
Title: TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans.
expressed exclusively in platelets and megakaryocytes; expression is up-regulated upon platelet activation; is prepackaged into both MK and platelet alpha-granules; may regulate granule construction or dispersal
Title: A TREM family member, TLT-1, is found exclusively in the alpha-granules of megakaryocytes and platelets.
initial characterization of TREM-like transcript (TLT)-1; results indicate it is likely that TLT-1 regulates the signaling of the TREM family receptors
Title: Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster.
A soluble fragment of the TLT-1 extracellular domain is found in serum of humans and mice and that an isoform of similar mass is released from platelets following activation with thrombin.
Title: The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	TAS Traceable Author Statement more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in platelet activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in platelet activation	IEP Inferred from Expression Pattern more info	PubMed
involved_in wound healing	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in platelet alpha granule	IDA Inferred from Direct Assay more info	PubMed
located_in platelet alpha granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: trem-like transcript 1 protein

Names: triggering receptor expressed on myeloid cells-like 1c; triggering receptor expressed on myeloid cells-like 1d; triggering receptor expressed on myeloid cells-like 1e; triggering receptor expressed on myeloid cells-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289451.1 → NP_001276380.1 trem-like transcript 1 protein isoform 2 precursor

See identical proteins and their annotated locations for NP_001276380.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses alternate splice sites in the coding region, which result in a frameshift, compared to variant 1. This results in an isoform (2) with a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AI553593, AK017256, DQ087183

Consensus CDS

CCDS89115.1

UniProtKB/TrEMBL

A6XA75

Related

ENSMUSP00000153104.2, ENSMUST00000225849.2

Conserved Domains (1) summary

cl11960
Location:26 → 108

Ig; Immunoglobulin domain
NM_001289457.1 → NP_001276386.1 trem-like transcript 1 protein isoform 3 precursor

See identical proteins and their annotated locations for NP_001276386.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in an isoform (3) that is shorter, compared to isoform 1.

Source sequence(s)

AI553593, AK017256, AY078502

Consensus CDS

CCDS89114.1

UniProtKB/Swiss-Prot

B2RRH0, Q8K558, Q9D3N6

UniProtKB/TrEMBL

B7ZNI7

Related

ENSMUSP00000024792.8, ENSMUST00000024792.8

Conserved Domains (1) summary

cl11960
Location:26 → 108

Ig; Immunoglobulin domain
NM_027763.2 → NP_082039.1 trem-like transcript 1 protein isoform 1 precursor

See identical proteins and their annotated locations for NP_082039.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AI553593, AK079428, AY078502

Consensus CDS

CCDS28866.1

UniProtKB/TrEMBL

B7ZNI7

Related

ENSMUSP00000153300.2, ENSMUST00000224001.2

Conserved Domains (1) summary

cl11960
Location:26 → 108

Ig; Immunoglobulin domain

RNA

NR_110338.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses multiple alternate splice sites, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.

Source sequence(s)

AI553593, AK017256, DQ087181

Related

ENSMUST00000223956.2