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    Dzip1 DAZ interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 66573, updated on 21-Apr-2024

    Summary

    Official Symbol
    Dzip1provided by MGI
    Official Full Name
    DAZ interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1914311
    See related
    Ensembl:ENSMUSG00000042156 AllianceGenome:MGI:1914311
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2510025K24Rik; 2810422M04Rik
    Summary
    This gene encodes a zinc finger protein that has been demonstrated to interact with the deleted in azoospermia (DAZ) protein. DAZ plays an important role early in germ cell development to maintain the initial germ cell population. Deletion of this gene in mice compromises Hedgehog signaling during embryogenesis. Mouse embryos lacking the encoded protein show severe developmental defects with dorsalized neural tubes and underdeveloped somites. Alternative splicing of this gene results in multiple transcript variants. A pseudogene for this gene has been identified on chromosome 5. [provided by RefSeq, Jan 2015]
    Expression
    Broad expression in CNS E18 (RPKM 16.3), testis adult (RPKM 15.7) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    14 E4; 14 62.56 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (119112927..119162947, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (118875517..118925537, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene claudin 10 Neighboring gene predicted gene, 41248 Neighboring gene predicted gene, 32382 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:119237797-119237998 Neighboring gene STARR-positive B cell enhancer ABC_E4125 Neighboring gene DnaJ heat shock protein family (Hsp40) member C3 Neighboring gene coiled-coil domain-containing protein 58 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:119381910-119382076 Neighboring gene STARR-positive B cell enhancer mm9_chr14:119406665-119406966 Neighboring gene UDP-glucose glycoprotein glucosyltransferase 2 Neighboring gene predicted gene, 16835

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables BBSome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables BBSome binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ciliary basal body organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cilium organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cytoplasmic sequestering of protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heart development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within maintenance of protein location in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein localization to cilium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein localization to cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein localization to cilium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein localization to organelle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein-containing complex localization to centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sperm flagellum assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with centriole ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ciliary basal body IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary base IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ciliary transition fiber IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cilium assembly protein DZIP1
    Names
    DAZ-interacting protein 1 homolog
    DAZ-interacting zinc finger protein 1
    zinc finger protein DZIP1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360411.1NP_001347340.1  cilium assembly protein DZIP1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AA387689, AC154377, BC098211, BX525663, BY732624, CB244155, CB524461, CX769150
      UniProtKB/TrEMBL
      Q3URS5
      Conserved Domains (3) summary
      TIGR02168
      Location:104437
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00018
      Location:183207
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13815
      Location:43163
      Dzip-like_N; Iguana/Dzip1-like DAZ-interacting protein N-terminal
    2. NM_001360412.1NP_001347341.1  cilium assembly protein DZIP1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AA387689, AC154377, BC098211, BX525663, BY732624, CB244155, CB524461, CX769150
      Conserved Domains (1) summary
      pfam17060
      Location:123217
      MPS2; Monopolar spindle protein 2
    3. NM_001360413.1NP_001347342.1  cilium assembly protein DZIP1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AA387689, AC154377, BC098211, BX525663, BY732624, CD806726
      Conserved Domains (1) summary
      pfam17060
      Location:123217
      MPS2; Monopolar spindle protein 2
    4. NM_001427237.1NP_001414166.1  cilium assembly protein DZIP1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC154377
      UniProtKB/Swiss-Prot
      Q4QQM0, Q6ZQ10, Q8BMD2, Q9CRK5
    5. NM_001427238.1NP_001414167.1  cilium assembly protein DZIP1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC154377
    6. NM_025943.3NP_080219.2  cilium assembly protein DZIP1 isoform 1

      See identical proteins and their annotated locations for NP_080219.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the protein.
      Source sequence(s)
      AC154377, BC098211, BX525663, BY296162, BY732624
      Consensus CDS
      CCDS37011.1
      UniProtKB/Swiss-Prot
      Q4QQM0, Q6ZQ10, Q8BMD2, Q9CRK5
      UniProtKB/TrEMBL
      Q3URS5
      Related
      ENSMUSP00000004055.9, ENSMUST00000004055.10
      Conserved Domains (3) summary
      TIGR02168
      Location:104438
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00018
      Location:183207
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13815
      Location:43163
      Dzip-like_N; Iguana/Dzip1-like DAZ-interacting protein N-terminal

    RNA

    1. NR_130725.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two exons in the 5' region and contains an alternate internal exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC154377, BC098211, BX525663, BY732624
      Related
      ENSMUST00000228157.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      119112927..119162947 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247933.2XP_030103793.1  cilium assembly protein DZIP1 isoform X1

      UniProtKB/Swiss-Prot
      Q4QQM0, Q6ZQ10, Q8BMD2, Q9CRK5
      UniProtKB/TrEMBL
      Q3URS5
      Related
      ENSMUSP00000039689.6, ENSMUST00000047208.12
      Conserved Domains (3) summary
      TIGR02168
      Location:104438
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00018
      Location:183207
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13815
      Location:43163
      Dzip-like_N; Iguana/Dzip1-like DAZ-interacting protein N-terminal
    2. XM_011245146.4XP_011243448.1  cilium assembly protein DZIP1 isoform X1

      See identical proteins and their annotated locations for XP_011243448.1

      UniProtKB/Swiss-Prot
      Q4QQM0, Q6ZQ10, Q8BMD2, Q9CRK5
      UniProtKB/TrEMBL
      Q3URS5
      Conserved Domains (3) summary
      TIGR02168
      Location:104438
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00018
      Location:183207
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13815
      Location:43163
      Dzip-like_N; Iguana/Dzip1-like DAZ-interacting protein N-terminal
    3. XM_030247939.2XP_030103799.1  cilium assembly protein DZIP1 isoform X6

      Conserved Domains (1) summary
      pfam17060
      Location:123217
      MPS2; Monopolar spindle protein 2
    4. XM_030247936.2XP_030103796.1  cilium assembly protein DZIP1 isoform X4

      UniProtKB/TrEMBL
      Q3URS5
      Conserved Domains (4) summary
      sd00018
      Location:183207
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam17060
      Location:350444
      MPS2; Monopolar spindle protein 2
      pfam00096
      Location:183206
      zf-C2H2; Zinc finger, C2H2 type
      pfam13815
      Location:43163
      Dzip-like_N; Iguana/Dzip1-like DAZ-interacting protein N-terminal
    5. XM_006519387.4XP_006519450.1  cilium assembly protein DZIP1 isoform X3

      UniProtKB/TrEMBL
      Q3URS5
      Conserved Domains (5) summary
      TIGR02168
      Location:217510
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00018
      Location:183207
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam17060
      Location:351445
      MPS2; Monopolar spindle protein 2
      pfam00096
      Location:183206
      zf-C2H2; Zinc finger, C2H2 type
      pfam13815
      Location:43163
      Dzip-like_N; Iguana/Dzip1-like DAZ-interacting protein N-terminal
    6. XM_030247934.2XP_030103794.1  cilium assembly protein DZIP1 isoform X2

      UniProtKB/TrEMBL
      Q3URS5
      Conserved Domains (3) summary
      TIGR02168
      Location:104437
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00018
      Location:183207
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13815
      Location:43163
      Dzip-like_N; Iguana/Dzip1-like DAZ-interacting protein N-terminal
    7. XM_030247942.2XP_030103802.1  cilium assembly protein DZIP1 isoform X7

      Conserved Domains (1) summary
      pfam17060
      Location:122216
      MPS2; Monopolar spindle protein 2
    8. XM_036158794.1XP_036014687.1  cilium assembly protein DZIP1 isoform X7

      Conserved Domains (1) summary
      pfam17060
      Location:122216
      MPS2; Monopolar spindle protein 2
    9. XM_030247937.2XP_030103797.1  cilium assembly protein DZIP1 isoform X6

      Conserved Domains (1) summary
      pfam17060
      Location:123217
      MPS2; Monopolar spindle protein 2
    10. XM_030247943.2XP_030103803.1  cilium assembly protein DZIP1 isoform X7

      Conserved Domains (1) summary
      pfam17060
      Location:122216
      MPS2; Monopolar spindle protein 2
    11. XM_030247938.2XP_030103798.1  cilium assembly protein DZIP1 isoform X6

      Conserved Domains (1) summary
      pfam17060
      Location:123217
      MPS2; Monopolar spindle protein 2
    12. XM_036158793.1XP_036014686.1  cilium assembly protein DZIP1 isoform X6

      Conserved Domains (1) summary
      pfam17060
      Location:123217
      MPS2; Monopolar spindle protein 2
    13. XM_006519384.3XP_006519447.1  cilium assembly protein DZIP1 isoform X1

      See identical proteins and their annotated locations for XP_006519447.1

      UniProtKB/Swiss-Prot
      Q4QQM0, Q6ZQ10, Q8BMD2, Q9CRK5
      UniProtKB/TrEMBL
      Q3URS5
      Conserved Domains (3) summary
      TIGR02168
      Location:104438
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00018
      Location:183207
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13815
      Location:43163
      Dzip-like_N; Iguana/Dzip1-like DAZ-interacting protein N-terminal
    14. XM_006519388.5XP_006519451.1  cilium assembly protein DZIP1 isoform X5

      See identical proteins and their annotated locations for XP_006519451.1

      Conserved Domains (1) summary
      pfam17060
      Location:159253
      MPS2; Monopolar spindle protein 2
    15. XM_030247940.2XP_030103800.1  cilium assembly protein DZIP1 isoform X6

      Conserved Domains (1) summary
      pfam17060
      Location:123217
      MPS2; Monopolar spindle protein 2
    16. XM_030247944.2XP_030103804.1  cilium assembly protein DZIP1 isoform X7

      Conserved Domains (1) summary
      pfam17060
      Location:122216
      MPS2; Monopolar spindle protein 2
    17. XM_030247941.2XP_030103801.1  cilium assembly protein DZIP1 isoform X6

      Conserved Domains (1) summary
      pfam17060
      Location:123217
      MPS2; Monopolar spindle protein 2
    18. XM_006519391.4XP_006519454.1  cilium assembly protein DZIP1 isoform X6

      See identical proteins and their annotated locations for XP_006519454.1

      UniProtKB/Swiss-Prot
      Q8BMD2
      Conserved Domains (1) summary
      pfam17060
      Location:123217
      MPS2; Monopolar spindle protein 2
    19. XM_006519389.5XP_006519452.1  cilium assembly protein DZIP1 isoform X5

      See identical proteins and their annotated locations for XP_006519452.1

      Conserved Domains (1) summary
      pfam17060
      Location:159253
      MPS2; Monopolar spindle protein 2
    20. XM_006519386.4XP_006519449.1  cilium assembly protein DZIP1 isoform X2

      UniProtKB/TrEMBL
      Q3URS5
      Conserved Domains (3) summary
      TIGR02168
      Location:104437
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00018
      Location:183207
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13815
      Location:43163
      Dzip-like_N; Iguana/Dzip1-like DAZ-interacting protein N-terminal
    21. XM_030247945.1XP_030103805.1  cilium assembly protein DZIP1 isoform X8

      Conserved Domains (1) summary
      pfam17060
      Location:123217
      MPS2; Monopolar spindle protein 2

    RNA

    1. XR_383203.5 RNA Sequence

    2. XR_003950893.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_025640.2: Suppressed sequence

      Description
      NM_025640.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.