Glipr2 GLI pathogenesis-related 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Glipr2provided by MGI
Official Full Name: GLI pathogenesis-related 2provided by MGI
Primary source: MGI:MGI:1917770
See related: Ensembl:ENSMUSG00000028480 AllianceGenome:MGI:1917770
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GAPR-1; 5730414A08Rik
Summary: Predicted to enable protein homodimerization activity. Predicted to be involved in positive regulation of ERK1 and ERK2 cascade; positive regulation of epithelial cell migration; and positive regulation of epithelial to mesenchymal transition. Predicted to be located in Golgi membrane. Predicted to be active in extracellular space. Is expressed in diaphragm; limb; tail paraxial mesenchyme; tongue; and vertebral axis musculature. Orthologous to human GLIPR2 (GLI pathogenesis related 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in limb E14.5 (RPKM 23.2), liver E18 (RPKM 18.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B1; 4 23.07 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (43957702..43979118)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (43957702..43979118)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GLIPR2 is a negative regulator of autophagy and the BECN1-ATG14-containing phosphatidylinositol 3-kinase complex.
Title: GLIPR2 is a negative regulator of autophagy and the BECN1-ATG14-containing phosphatidylinositol 3-kinase complex.
miR-30e is downregulated in diabetic nephropathy, and the overexpression of miR-30e can inhibit GLIPR-2.
Title: miR-30e targets GLIPR-2 to modulate diabetic nephropathy: in vitro and in vivo experiments.
Increased GLIPR-2 expression in kidney contributes to development of fibrosis by increasing the pool of activated fibroblasts, possibly through the induction of epithelial to mesenchymal transition.
Title: The plant pathogenesis related protein GLIPR-2 is highly expressed in fibrotic kidney and promotes epithelial to mesenchymal transition in vitro.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1)
Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Golgi-associated plant pathogenesis-related protein 1

Names: gliPR 2; glioma pathogenesis-related protein 2; golgi-associated PR-1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027450.3 → NP_081726.1 Golgi-associated plant pathogenesis-related protein 1

See identical proteins and their annotated locations for NP_081726.1

Status: PROVISIONAL

Source sequence(s)

AL732563, AL772204

Consensus CDS

CCDS18117.1

UniProtKB/Swiss-Prot

Q3TJ42, Q8BTK4, Q9CYL5

Related

ENSMUSP00000030202.8, ENSMUST00000030202.14

Conserved Domains (1) summary

cd05382
Location:8 → 139

CAP_GAPR1-like; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of Golgi-associated plant pathogenesis-related protein 1 and similar proteins