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    Mamdc2 MAM domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 71738, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mamdc2provided by MGI
    Official Full Name
    MAM domain containing 2provided by MGI
    Primary source
    MGI:MGI:1918988
    See related
    Ensembl:ENSMUSG00000033207 AllianceGenome:MGI:1918988
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mamcan; 1200015L10Rik
    Summary
    Enables glycosaminoglycan binding activity. Acts upstream of or within peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan. Located in interstitial matrix. Is expressed in embryo and rib. Orthologous to human MAMDC2 (MAM domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in lung adult (RPKM 30.1), subcutaneous fat pad adult (RPKM 9.7) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mamdc2 in Genome Data Viewer
    Location:
    19 B; 19 18.22 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (23279973..23425855, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (23302609..23448497, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene structural maintenance of chromosomes 5 Neighboring gene STARR-positive B cell enhancer mm9_chr19:23348377-23348678 Neighboring gene predicted gene, 33950 Neighboring gene STARR-seq mESC enhancer starr_45773 Neighboring gene predicted gene, 24263 Neighboring gene predicted gene, 41821 Neighboring gene STARR-seq mESC enhancer starr_45774 Neighboring gene STARR-seq mESC enhancer starr_45776 Neighboring gene predicted gene, 34012 Neighboring gene STARR-seq mESC enhancer starr_45777 Neighboring gene cilia and flagella associated protein 95 Neighboring gene 40S ribosomal protein S7 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of Modifier Genes in a Mouse Model of Gaucher Disease. Klein AD, et al. Cell Rep, 2016 Sep 6. PMID 27568557
    2. Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling. Yorgan TA, et al. Bone, 2019 Oct. PMID 31202927
    3. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glycosaminoglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in interstitial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MAM domain-containing protein 2
    Names
    MAM domain-containing proteoglycan

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174857.3 → NP_777282.1  MAM domain-containing protein 2 precursor

      See identical proteins and their annotated locations for NP_777282.1

      Status: PROVISIONAL

      Source sequence(s)
      AC124557, AC131118, AC144941
      Consensus CDS
      CCDS29707.1
      UniProtKB/TrEMBL
      A0A0R4J0J7, Q3U4I9
      Related
      ENSMUSP00000045432.7, ENSMUST00000036069.8
      Conserved Domains (2) summary
      cd06263
      Location:509 → 664
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam00629
      Location:509 → 666
      MAM; MAM domain, meprin/A5/mu

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      23279973..23425855 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161694.1 → XP_036017587.1  MAM domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      Q3U4I9
      Conserved Domains (2) summary
      cd06263
      Location:512 → 667
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam00629
      Location:173 → 330
      MAM; MAM domain, meprin/A5/mu

    RNA

    1. XR_004940174.1 RNA Sequence

    2. XR_003952820.2 RNA Sequence

      Related
      ENSMUST00000236349.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CG85.1 GenPept UniProtKB/Swiss-Prot:Q8CG85

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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