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    Dcaf6 DDB1 and CUL4 associated factor 6 [ Mus musculus (house mouse) ]

    Gene ID: 74106, updated on 23-Jun-2021

    Summary

    Official Symbol
    Dcaf6provided by MGI
    Official Full Name
    DDB1 and CUL4 associated factor 6provided by MGI
    Primary source
    MGI:MGI:1921356
    See related
    Ensembl:ENSMUSG00000026571
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Iqwd; PC32; Iqwd1; PC326; 1200006M05Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 41.3), cortex adult (RPKM 13.4) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dcaf6 in Genome Data Viewer
    Location:
    1; 1 H2.2- H2.3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (165157069..165288475, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (165329500..165460906, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (167259631..167390594, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene SFT2 domain containing 2 Neighboring gene TIP41, TOR signalling pathway regulator-like (S. cerevisiae) Neighboring gene G protein-coupled receptor 161 Neighboring gene predicted gene, 24637 Neighboring gene mitochondrial pyruvate carrier 2 Neighboring gene adenylate cyclase 10 Neighboring gene peptidylprolyl isomerase A pseudogene 1_1625.1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DDB1- and CUL4-associated factor 6
    Names
    IQ motif and WD repeat-containing protein 1
    IQ motif and WD repeats 1
    NRIP
    nuclear receptor interaction protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028759.1NP_083035.1  DDB1- and CUL4-associated factor 6

      See identical proteins and their annotated locations for NP_083035.1

      Status: VALIDATED

      Source sequence(s)
      AC116374, AC162789
      Consensus CDS
      CCDS48424.1
      UniProtKB/Swiss-Prot
      Q9DC22
      Related
      ENSMUSP00000027856.8, ENSMUST00000027856.13
      Conserved Domains (3) summary
      COG2319
      Location:42281
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:5592
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:43292
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      165157069..165288475 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243204.1XP_030099064.1  DDB1- and CUL4-associated factor 6 isoform X7

      Conserved Domains (2) summary
      sd00039
      Location:4899
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:5145
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_036153945.1XP_036009838.1  DDB1- and CUL4-associated factor 6 isoform X8

      Conserved Domains (1) summary
      cl29593
      Location:599658
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_036153915.1XP_036009808.1  DDB1- and CUL4-associated factor 6 isoform X1

      Conserved Domains (2) summary
      sd00039
      Location:5592
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:43292
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. XM_036153926.1XP_036009819.1  DDB1- and CUL4-associated factor 6 isoform X3

      Conserved Domains (2) summary
      sd00039
      Location:5592
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:43292
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. XM_036153932.1XP_036009825.1  DDB1- and CUL4-associated factor 6 isoform X5

      Conserved Domains (2) summary
      sd00039
      Location:5592
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:43292
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    6. XM_036153933.1XP_036009826.1  DDB1- and CUL4-associated factor 6 isoform X6

      Conserved Domains (2) summary
      sd00039
      Location:4899
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:5145
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    7. XM_036153936.1XP_036009829.1  DDB1- and CUL4-associated factor 6 isoform X6

      Conserved Domains (2) summary
      sd00039
      Location:4899
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:5145
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    8. XM_006497004.3XP_006497067.1  DDB1- and CUL4-associated factor 6 isoform X2

      Conserved Domains (2) summary
      sd00039
      Location:5592
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:43292
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    9. XM_006497005.3XP_006497068.1  DDB1- and CUL4-associated factor 6 isoform X4

      Conserved Domains (2) summary
      sd00039
      Location:5592
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:43292
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    10. XM_006497008.3XP_006497071.1  DDB1- and CUL4-associated factor 6 isoform X9

      Conserved Domains (2) summary
      sd00039
      Location:5592
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:43292
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    11. XM_036153948.1XP_036009841.1  DDB1- and CUL4-associated factor 6 isoform X9

      Conserved Domains (2) summary
      sd00039
      Location:5592
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:43292
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_004934804.1 RNA Sequence

    2. XR_004934805.1 RNA Sequence

    3. XR_373618.3 RNA Sequence

    4. XR_004934806.1 RNA Sequence

    5. XR_001778389.3 RNA Sequence

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