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    Fundc1 FUN14 domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 72018, updated on 2-May-2024

    Summary

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    Official Symbol
    Fundc1provided by MGI
    Official Full Name
    FUN14 domain containing 1provided by MGI
    Primary source
    MGI:MGI:1919268
    See related
    Ensembl:ENSMUSG00000025040 AllianceGenome:MGI:1919268
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500005J14Rik; 1810033P05Rik
    Summary
    Predicted to be involved in autophagy of mitochondrion; response to hypoxia; and response to organonitrogen compound. Predicted to act upstream of or within autophagy. Predicted to be located in mitochondrial outer membrane. Predicted to be integral component of mitochondrial outer membrane. Is expressed in thymus primordium. Orthologous to human FUNDC1 (FUN14 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 10.0), frontal lobe adult (RPKM 6.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X A1.2; X 12.8 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (17386206..17438600, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (17519967..17572329, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 35105 Neighboring gene predicted gene, 22294 Neighboring gene predicted gene, 39497 Neighboring gene STARR-seq mESC enhancer starr_46824 Neighboring gene STARR-seq mESC enhancer starr_46825 Neighboring gene STARR-seq mESC enhancer starr_46826 Neighboring gene STARR-seq mESC enhancer starr_46827 Neighboring gene mortality factor 4 like 2 pseudogene Neighboring gene heat shock protein 8 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Exercise protects aged mice against coronary endothelial senescence via FUNDC1-dependent mitophagy. Ma L, et al. Redox Biol, 2023 Jun. PMID 37030149, Free PMC Article
    2. Hypoxia Acclimation Protects against Heart Failure Postacute Myocardial Infarction via Fundc1-Mediated Mitophagy. Li Q, et al. Oxid Med Cell Longev, 2022. PMID 35422895, Free PMC Article
    3. FUNDC1 inhibits NLRP3-mediated inflammation after intracerebral hemorrhage by promoting mitophagy in mice. Zheng S, et al. Neurosci Lett, 2021 Jun 21. PMID 34022268
    4. Mitophagy receptor FUNDC1 is regulated by PGC-1α/NRF1 to fine tune mitochondrial homeostasis. Liu L, et al. EMBO Rep, 2021 Mar 3. PMID 33554448, Free PMC Article
    5. FUN14 domain-containing 1-mediated mitophagy suppresses interleukin-1β production in macrophages. Huang J, et al. Int Immunopharmacol, 2020 Nov. PMID 33182075

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Silencing of FUN14 Domain Containing 1 Inhibits Platelet Activation in Diabetes Mellitus through Blocking Mitophagy.
      Title: Silencing of FUN14 Domain Containing 1 Inhibits Platelet Activation in Diabetes Mellitus through Blocking Mitophagy.
    2. Neutrophil extracellular traps aggravate intestinal epithelial necroptosis in ischaemia-reperfusion by regulating TLR4/RIPK3/FUNDC1-required mitophagy.
      Title: Neutrophil extracellular traps aggravate intestinal epithelial necroptosis in ischaemia-reperfusion by regulating TLR4/RIPK3/FUNDC1-required mitophagy.
    3. FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner.
      Title: FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner.
    4. FUNDC1 modulates mitochondrial defects and pancreatic beta-cell dysfunction under lipotoxicity.
      Title: FUNDC1 modulates mitochondrial defects and pancreatic β-cell dysfunction under lipotoxicity.
    5. Exercise protects aged mice against coronary endothelial senescence via FUNDC1-dependent mitophagy.
      Title: Exercise protects aged mice against coronary endothelial senescence via FUNDC1-dependent mitophagy.
    6. FUNDC1 protects against doxorubicin-induced cardiomyocyte PANoptosis through stabilizing mtDNA via interaction with TUFM.
      Title: FUNDC1 protects against doxorubicin-induced cardiomyocyte PANoptosis through stabilizing mtDNA via interaction with TUFM.
    7. FUNDC1-mediated mitophagy and HIF1alpha activation drives pulmonary hypertension during hypoxia.
      Title: FUNDC1-mediated mitophagy and HIF1α activation drives pulmonary hypertension during hypoxia.
    8. Hypoxia Acclimation Protects against Heart Failure Postacute Myocardial Infarction via Fundc1-Mediated Mitophagy.
      Title: Hypoxia Acclimation Protects against Heart Failure Postacute Myocardial Infarction via Fundc1-Mediated Mitophagy.
    9. BI-1 ameliorates myocardial injury by activating the mitochondrial unfolded protein response and FUNDC1-related mitophagy in cardiorenal syndrome type 3.
      Title: BI-1 ameliorates myocardial injury by activating the mitochondrial unfolded protein response and FUNDC1-related mitophagy in cardiorenal syndrome type 3.
    10. FUNDC1 inhibits NLRP3-mediated inflammation after intracerebral hemorrhage by promoting mitophagy in mice.
      Title: FUNDC1 inhibits NLRP3-mediated inflammation after intracerebral hemorrhage by promoting mitophagy in mice.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (5)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within autophagy of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to organonitrogen compound ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FUN14 domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001313745.1 → NP_001300674.1  FUN14 domain-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' end compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK005163, BM934468, BX005345
      Consensus CDS
      CCDS85750.1
      UniProtKB/TrEMBL
      H3BJZ1
      Related
      ENSMUSP00000135183.2, ENSMUST00000176638.8
      Conserved Domains (1) summary
      pfam04930
      Location:54 → 110
      FUN14; FUN14 family

    2. NM_001313746.1 → NP_001300675.1  FUN14 domain-containing protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in place of the first exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      BM934468, BX005345, BY061369, CD805077
      Consensus CDS
      CCDS85749.1
      UniProtKB/TrEMBL
      H3BJ77
      Related
      ENSMUSP00000135026.2, ENSMUST00000142638.2
      Conserved Domains (1) summary
      pfam04930
      Location:11 → 110
      FUN14; FUN14 family

    3. NM_028058.4 → NP_082334.1  FUN14 domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_082334.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK005163, BM934468, BX005345
      Consensus CDS
      CCDS30035.1
      UniProtKB/Swiss-Prot
      A2BEA3, Q9DB70
      Related
      ENSMUSP00000026016.7, ENSMUST00000026016.13
      Conserved Domains (1) summary
      pfam04930
      Location:54 → 153
      FUN14; FUN14 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      17386206..17438600 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247496.4 → XP_011245798.1  FUN14 domain-containing protein 1 isoform X1

      Conserved Domains (1) summary
      pfam04930
      Location:54 → 93
      FUN14; FUN14 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DB70.1 GenPept UniProtKB/Swiss-Prot:Q9DB70

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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