Spink12 serine peptidase inhibitor, Kazal type 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spink12provided by MGI
Official Full Name: serine peptidase inhibitor, Kazal type 12provided by MGI
Primary source: MGI:MGI:1925492
See related: Ensembl:ENSMUSG00000061144 AllianceGenome:MGI:1925492
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9230117E20Rik
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within negative regulation of proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward genital fat pad adult (RPKM 104.5) See more
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Genomic context

Location:: 18 B3; 18 23.74 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (44237357..44241610)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (44104290..44108543)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

spink12 is especially expressed in the epidermal areas with thick skin and its regulation generally responds to differentiation signals.
Title: Expression and regulation of murine SPINK12, a potential orthologue of human LEKTI2.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of proteolysis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine protease inhibitor Kazal-type 12

Names: serine peptidase inhibitor, Kazal type 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030061.4 → NP_084337.2 serine protease inhibitor Kazal-type 12 precursor

Status: VALIDATED

Source sequence(s)

AK136616

Consensus CDS

CCDS29225.1

UniProtKB/Swiss-Prot

Q9D256

UniProtKB/TrEMBL

A0A0R4J109

Related

ENSMUSP00000080025.7, ENSMUST00000081271.7

Conserved Domains (1) summary

cd01327
Location:42 → 87

KAZAL_PSTI; Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

44237357..44241610

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250632.1 → XP_030106492.1 serine protease inhibitor Kazal-type 12 isoform X1

UniProtKB/Swiss-Prot

Q9D256

UniProtKB/TrEMBL

A0A0R4J109

Conserved Domains (1) summary

cd01327
Location:42 → 87

KAZAL_PSTI; Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the ...