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    Urb1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 207932, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Urb1provided by MGI
    Official Full Name
    URB1 ribosome biogenesis 1 homolog (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:2146468
    See related
    Ensembl:ENSMUSG00000039929 AllianceGenome:MGI:2146468
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0539; 4921511H13Rik; 5730405K23Rik
    Summary
    Predicted to be involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in fibrillar center. Predicted to be active in nucleolus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human URB1 (URB1 ribosome biogenesis homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 8.9), CNS E11.5 (RPKM 3.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Urb1 in Genome Data Viewer
    Location:
    16 C3.3; 16 51.92 cM
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (90548415..90607312, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (90751527..90810467, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr16:90727472-90727773 Neighboring gene predicted gene, 17518 Neighboring gene melanocortin 2 receptor accessory protein Neighboring gene STARR-seq mESC enhancer starr_41464 Neighboring gene STARR-positive B cell enhancer ABC_E1929 Neighboring gene eva-1 homolog C Neighboring gene predicted gene, 36363 Neighboring gene STARR-seq mESC enhancer starr_41466 Neighboring gene STARR-seq mESC enhancer starr_41467 Neighboring gene STARR-seq mESC enhancer starr_41468 Neighboring gene predicted gene, 53919 Neighboring gene cilia and flagella associate protien 298

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nucleolar URB1 ensures 3' ETS rRNA removal to prevent exosome surveillance. Shan L, et al. Nature, 2023 Mar. PMID 36890225
    2. Genetic analysis of Down syndrome-associated heart defects in mice. Liu C, et al. Hum Genet, 2011 Nov. PMID 21442329, Free PMC Article
    3. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Grebien F, et al. Nat Chem Biol, 2015 Aug. PMID 26167872, Free PMC Article
    4. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855
    5. Human chromosome 21 gene expression atlas in the mouse. Reymond A, et al. Nature, 2002 Dec 5. PMID 12466854

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nucleolar URB1 ensures 3' ETS rRNA removal to prevent exosome surveillance.
      Title: Nucleolar URB1 ensures 3' ETS rRNA removal to prevent exosome surveillance.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0539

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar pre-ribosomal-associated protein 1
    Names
    nucleolar preribosomal-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029497.1 → NP_083773.1  nucleolar pre-ribosomal-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      AK050735, AK220219, BB658427, BE943636, BU058447, BX522964, CD541646, CF534743, CK391060
      Consensus CDS
      CCDS49905.1
      UniProtKB/Swiss-Prot
      Q571H0, Q9CYN4
      UniProtKB/TrEMBL
      E9PU96
      Related
      ENSMUSP00000114717.2, ENSMUST00000140920.2
      Conserved Domains (2) summary
      pfam11707
      Location:78 → 396
      Npa1; Ribosome 60S biogenesis N-terminal
      pfam16201
      Location:1670 → 1859
      NopRA1; Nucleolar pre-ribosomal-associated protein 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      90548415..90607312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522977.4 → XP_006523040.1  nucleolar pre-ribosomal-associated protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q571H0, Q9CYN4
      Conserved Domains (2) summary
      pfam11707
      Location:78 → 396
      Npa1; Ribosome 60S biogenesis N-terminal
      pfam16201
      Location:1610 → 1799
      NopRA1; Nucleolar pre-ribosomal-associated protein 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q571H0.2 GenPept UniProtKB/Swiss-Prot:Q571H0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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