Cdh13 cadherin 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdh13provided by MGI
Official Full Name: cadherin 13provided by MGI
Primary source: MGI:MGI:99551
See related: Ensembl:ENSMUSG00000031841 AllianceGenome:MGI:99551
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cdht; Tcad; 4932416G01Rik
Summary: This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. This gene is highly expressed in the vasculature including endothelial cells, smooth muscle cells and pericytes, where the encoded protein binds to adiponectin and has been implicated in the modulation of angiogenesis. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Nov 2015]
Expression: Broad expression in heart adult (RPKM 39.2), CNS E18 (RPKM 17.5) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 65.97 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (119010150..120051668)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (118140017..119324929)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ER stress decreases exosome production through adiponectin/T-cadherin-dependent and -independent pathways.
Title: ER stress decreases exosome production through adiponectin/T-cadherin-dependent and -independent pathways.
T-Cadherin Deficiency Is Associated with Increased Blood Pressure after Physical Activity.
Title: T-Cadherin Deficiency Is Associated with Increased Blood Pressure after Physical Activity.
Serotonin (5-HT) neuron-specific inactivation of Cadherin-13 impacts 5-HT system formation and cognitive function.
Title: Serotonin (5-HT) neuron-specific inactivation of Cadherin-13 impacts 5-HT system formation and cognitive function.
Increased vascular permeability and severe renal tubular damage after ischemia-reperfusion injury in mice lacking adiponectin or T-cadherin.
Title: Increased vascular permeability and severe renal tubular damage after ischemia-reperfusion injury in mice lacking adiponectin or T-cadherin.
Plasma proteomic profiling of young and old mice reveals cadherin-13 prevents age-related bone loss.
Title: Plasma proteomic profiling of young and old mice reveals cadherin-13 prevents age-related bone loss.
Studied role of cadherin 13 (CDH13) levels in adipose tissue and obesity; found CDH13 levels are affected by obesity in mouse models and humans and are restored by weight loss in humans.
Title: CDH13 abundance interferes with adipocyte differentiation and is a novel biomarker for adipose tissue health.
Neonatal maternal separation (MS) lead to increased anxiety-like behavior in Cdh13(-/-) mice compared to the other two MS groups. Cdh13(-/-) mice showed a context-dependent effect on stress- & anxiety-related behavior, impaired extinction learning following contextual fear conditioning & decreased impulsivity, & a mild decrease in errors in the Barnes maze & reduced risk-taking in the light-dark transition test after MS.
Title: Early-life stress impairs developmental programming in Cadherin 13 (CDH13)-deficient mice.
Findings show that Cdh13 is critical for inhibitory function of Golgi cells, and that GlyT2::Cre-mediated deletion of Cdh13 in non-executive centers of the brain, such as the cerebellum, may contribute to cognitive and social behavioral deficits linked to neurological disorders.
Title: Conditional deletion of Cadherin 13 perturbs Golgi cells and disrupts social and cognitive behaviors.
Studies findings identified a novel protective role for cadherin-13 in cortical neuron development.
Title: Protective role of Cadherin 13 in interneuron development.
using rat and murine aortic smooth muscle cells as experimental models, we surveyed the ability of T-cadherin to regulate autophagy in SMCs during serum-starvation stress. Overall our findings have identified T-cadherin as a novel positive regulator of autophagy and survival in smooth muscle cells
Title: T-cadherin promotes autophagy and survival in vascular smooth muscle cells through MEK1/2/Erk1/2 axis activation.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

stSG611434 (e-PCR)
- UniSTS:449830

D8Mit168 (e-PCR), detects polymorphism
- UniSTS:131373

D8Mit187 (e-PCR), detects polymorphism
- UniSTS:131395

D8Mit120 (e-PCR), detects polymorphism
- UniSTS:116351

03.MMHAP8FRA9.seq (e-PCR)
- UniSTS:122755

D8Mit275 (e-PCR), detects polymorphism
- UniSTS:131486

RH124362 (e-PCR)
- UniSTS:161184

RH124402 (e-PCR)
- UniSTS:161224

Z49877 (e-PCR)
- UniSTS:163535

D8Mit322 (e-PCR), detects polymorphism
- UniSTS:131538

Cdh13 (e-PCR), detects polymorphism
- UniSTS:507866

18.MMHAP23FRF9.seq (e-PCR)
- UniSTS:123373

D8Mit361 (e-PCR), detects polymorphism
- UniSTS:131579

D8Mit362 (e-PCR), detects polymorphism
- UniSTS:131580

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables adiponectin binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in adherens junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion mediated by cadherin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in localization within membrane	ISO Inferred from Sequence Orthology more info
involved_in low-density lipoprotein particle mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of positive chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cadherin-13

Names: H-cadherin; T-cadherin; heart cadherin

NP_062681.2

EC 3.6.1.3

XP_006530691.2

EC 3.6.1.3

XP_036009632.1

EC 3.6.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019707.5 → NP_062681.2 cadherin-13 preproprotein

See identical proteins and their annotated locations for NP_062681.2

Status: REVIEWED

Source sequence(s)

AI550332, AK048724, AV343697, BB075948, BM944611, CF735928, CX242668

Consensus CDS

CCDS52682.1

UniProtKB/Swiss-Prot

Q8BG11, Q9WTR5

UniProtKB/TrEMBL

Q8VDK4

Related

ENSMUSP00000113527.2, ENSMUST00000117160.2

Conserved Domains (4) summary

cd11304
Location:488 → 581

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:161 → 243

CA; Cadherin repeats

pfam00028
Location:368 → 469

Cadherin; Cadherin domain

pfam08758
Location:26 → 112

Cadherin_pro; Cadherin prodomain like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

119010150..120051668

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153739.1 → XP_036009632.1 cadherin-13 isoform X2

UniProtKB/TrEMBL

Q8BS79

Conserved Domains (2) summary

smart00112
Location:161 → 243

CA; Cadherin repeats

pfam08758
Location:26 → 112

Cadherin_pro; Cadherin prodomain like
XM_006530628.4 → XP_006530691.2 cadherin-13 isoform X1

UniProtKB/TrEMBL

Q8VDK4

Conserved Domains (4) summary

cd11304
Location:475 → 568

Cadherin_repeat; Cadherin tandem repeat domain

smart00112
Location:148 → 230

CA; Cadherin repeats

cl29226
Location:577 → 667

Cadherin; Cadherin domain

pfam08758
Location:13 → 99

Cadherin_pro; Cadherin prodomain like