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    Nudt13 nudix hydrolase 13 [ Mus musculus (house mouse) ]

    Gene ID: 67725, updated on 28-Apr-2024

    Summary

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    Official Symbol
    Nudt13provided by MGI
    Official Full Name
    nudix hydrolase 13provided by MGI
    Primary source
    MGI:MGI:1914975
    See related
    Ensembl:ENSMUSG00000021809 AllianceGenome:MGI:1914975
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933433B15Rik
    Summary
    Enables NADH pyrophosphatase activity. Involved in NADH metabolic process and NADP catabolic process. Located in mitochondrion. Is expressed in brain; endocrine gland; genitourinary system; and trachea. Orthologous to human NUDT13 (nudix hydrolase 13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 3.1), bladder adult (RPKM 3.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 A3; 14 11.5 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20344709..20367652)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20294679..20317584)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene potassium channel, subfamily K, member 17 pseudogene Neighboring gene potassium channel, subfamily K, member 16 Neighboring gene STARR-positive B cell enhancer ABC_E1470 Neighboring gene ecdysoneless cell cycle regulator Neighboring gene STARR-seq mESC enhancer starr_36108 Neighboring gene STARR-positive B cell enhancer ABC_E7295 Neighboring gene family with sequence similarity 149, member B Neighboring gene predicted gene, 30054

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse Nudt13 is a Mitochondrial Nudix Hydrolase with NAD(P)H Pyrophosphohydrolase Activity. Abdelraheim SR, et al. Protein J, 2017 Oct. PMID 28755312, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2) 
    • Gene trapped (1) 

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+ diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH pyrophosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NADH metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in NADP catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NAD(P)H pyrophosphatase NUDT13, mitochondrial
    Names
    nucleoside diphosphate-linked moiety X motif 13
    nudix (nucleoside diphosphate linked moiety X)-type motif 13
    nudix motif 13
    NP_001346797.1
    NP_001346798.1
    NP_001346799.1
    NP_080617.2
    XP_006519526.1
    XP_006519531.1
    XP_006519534.1
    XP_011243461.1
    XP_011243466.1
    XP_030103834.1
    XP_036014722.1
    XP_036014723.1
    XP_036014724.1
    XP_036014725.1
    XP_036014726.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359868.1 → NP_001346797.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC159106, AK014204, AK161922, BB838132, BE987250, BY034640
      UniProtKB/TrEMBL
      Q80VI7
      Conserved Domains (1) summary
      COG2816
      Location:49 → 360
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

    2. NM_001359869.1 → NP_001346798.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC159106, AK014204, AK161922, BB838132, BE987250, BY034640
      Conserved Domains (2) summary
      pfam09296
      Location:63 → 179
      NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
      pfam09297
      Location:183 → 212
      zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain

    3. NM_001359870.1 → NP_001346799.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC159106, AK014204, AK161922, BB838132, BE987250, BQ749237
      Conserved Domains (1) summary
      COG2816
      Location:1 → 217
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

    4. NM_026341.3 → NP_080617.2  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_080617.2

      Status: VALIDATED

      Source sequence(s)
      AC159106, AK014204, AK161922, BB838132, BE987250, BY034640
      Consensus CDS
      CCDS36815.1
      UniProtKB/Swiss-Prot
      Q8JZU0, Q9CXN4
      UniProtKB/TrEMBL
      Q80VI7
      Related
      ENSMUSP00000022343.5, ENSMUST00000022343.6
      Conserved Domains (4) summary
      COG2816
      Location:32 → 343
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]
      cd03429
      Location:200 → 343
      NADH_pyrophosphatase; NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for ...
      pfam09296
      Location:46 → 162
      NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
      pfam09297
      Location:166 → 195
      zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain

    RNA

    1. NR_153363.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159106, AK017031, AK161922, BB838132, BE987250
      Related
      ENSMUST00000225722.2

    2. NR_153364.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159106, AK017031, AK161922, BB838132, BE987250

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      20344709..20367652
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158831.1 → XP_036014724.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X4

      Conserved Domains (1) summary
      COG2816
      Location:1 → 217
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

    2. XM_036158829.1 → XP_036014722.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q80VI7
      Conserved Domains (1) summary
      COG2816
      Location:49 → 360
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

    3. XM_011245159.2 → XP_011243461.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_011243461.1

      UniProtKB/TrEMBL
      Q80VI7
      Conserved Domains (1) summary
      COG2816
      Location:49 → 360
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

    4. XM_030247974.2 → XP_030103834.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X4

      Conserved Domains (1) summary
      COG2816
      Location:1 → 217
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

    5. XM_011245164.2 → XP_011243466.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X4

      See identical proteins and their annotated locations for XP_011243466.1

      Conserved Domains (1) summary
      COG2816
      Location:1 → 217
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

    6. XM_006519463.3 → XP_006519526.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006519526.1

      UniProtKB/TrEMBL
      Q80VI7
      Conserved Domains (1) summary
      COG2816
      Location:36 → 347
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

    7. XM_006519468.5 → XP_006519531.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X4

      See identical proteins and their annotated locations for XP_006519531.1

      Conserved Domains (1) summary
      COG2816
      Location:1 → 217
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

    8. XM_036158830.1 → XP_036014723.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A286YE01
      Related
      ENSMUSP00000153437.2, ENSMUST00000223941.2
      Conserved Domains (2) summary
      pfam09296
      Location:47 → 162
      NUDIX-like; NADH pyrophosphatase-like rudimentary NUDIX domain
      pfam09297
      Location:166 → 195
      zf-NADH-PPase; NADH pyrophosphatase zinc ribbon domain

    9. XM_036158833.1 → XP_036014726.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X4

      Conserved Domains (1) summary
      COG2816
      Location:1 → 217
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

    10. XM_006519471.4 → XP_006519534.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X4

      See identical proteins and their annotated locations for XP_006519534.1

      Conserved Domains (1) summary
      COG2816
      Location:1 → 217
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

    11. XM_036158832.1 → XP_036014725.1  NAD(P)H pyrophosphatase NUDT13, mitochondrial isoform X4

      Conserved Domains (1) summary
      COG2816
      Location:1 → 217
      NPY1; NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]

    RNA

    1. XR_004938441.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8JZU0.2 GenPept UniProtKB/Swiss-Prot:Q8JZU0

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