Cxxc1 CXXC finger protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cxxc1provided by MGI
Official Full Name: CXXC finger protein 1provided by MGI
Primary source: MGI:MGI:1921572
See related: Ensembl:ENSMUSG00000024560 AllianceGenome:MGI:1921572
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cfp1; Cgbp; PHF18; 2410002I16Rik; 5830420C16Rik
Summary: Enables methylated histone binding activity. Predicted to be involved in histone H3-K4 methylation and positive regulation of transcription, DNA-templated. Located in nuclear matrix. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and retina. Orthologous to human CXXC1 (CXXC finger protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 26.1), spleen adult (RPKM 21.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E2; 18 50.7 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (74349283..74354564)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (74216212..74221493)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CFP1 governs uterine epigenetic landscapes to intervene in progesterone responses for uterine physiology and suppression of endometriosis.
Title: CFP1 governs uterine epigenetic landscapes to intervene in progesterone responses for uterine physiology and suppression of endometriosis.
Expression of the histone lysine methyltransferases SETD1B, SETDB1, SETD2, and CFP1 exhibits significant changes in the oocytes and granulosa cells of aged mouse ovaries.
Title: Expression of the histone lysine methyltransferases SETD1B, SETDB1, SETD2, and CFP1 exhibits significant changes in the oocytes and granulosa cells of aged mouse ovaries.
Deficiency of CXXC finger protein 1 leads to small changes in heart rate but moderate epigenetic alterations and significant protein downregulation of hyperpolarization-activated cyclic nucleotide-gated 4 (HCN4) ion channels in mice.
Title: Deficiency of CXXC finger protein 1 leads to small changes in heart rate but moderate epigenetic alterations and significant protein downregulation of hyperpolarization-activated cyclic nucleotide-gated 4 (HCN4) ion channels in mice.
The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation.
Title: The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation.
Role of CxxC-finger protein 1 in establishing mouse oocyte epigenetic landscapes.
Title: Role of CxxC-finger protein 1 in establishing mouse oocyte epigenetic landscapes.
CXXC finger protein 1-mediated histone H3 lysine-4 trimethylation is essential for proper meiotic crossover formation in mice.
Title: CXXC finger protein 1-mediated histone H3 lysine-4 trimethylation is essential for proper meiotic crossover formation in mice.
A key role for Cfp1 in establishing a complex active promoter chromatin state.
Title: Cfp1 is required for gene expression-dependent H3K4 trimethylation and H3K9 acetylation in embryonic stem cells.
These data define the Cfp1 PHD domain as a reader of histone H3K4me marks and provide evidence that this activity is involved in the regulation of lineage commitment in ES cells.
Title: Efficient differentiation of murine embryonic stem cells requires the binding of CXXC finger protein 1 to DNA or methylated histone H3-Lys4.
Oocytes lacking CFP1 failed to complete maturation and were unable to gain developmental competence after fertilization, due to defects in cytoplasmic lattice formation, meiotic division, and maternal-zygotic transition.
Title: CFP1 Regulates Histone H3K4 Trimethylation and Developmental Potential in Mouse Oocytes.
Dual inhibition of CFP1 removes the SETD1-CFP1 complex from chromatin and ensures appropriate chromosome configuration changes during meiosis and mitosis.
Title: CFP1 coordinates histone H3 lysine-4 trimethylation and meiotic cell cycle progression in mouse oocytes.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237842

RH128295 (e-PCR)
- UniSTS:211603

AI426635 (e-PCR)
- UniSTS:160763

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables unmethylated CpG binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Set1C/COMPASS complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Set1C/COMPASS complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of histone methyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CXXC-type zinc finger protein 1

Names: CXXC finger 1 (PHD domain); CpG binding protein; PHD finger and CXXC domain-containing protein 1; cpG-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001378844.1 → NP_001365773.1 CXXC-type zinc finger protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC133186

UniProtKB/TrEMBL

Q3UIZ4

Conserved Domains (3) summary

cd15553
Location:28 → 73

PHD_Cfp1; PHD finger found in CXXC-type zinc finger protein 1 (Cfp1)

pfam02008
Location:166 → 212

zf-CXXC; CXXC zinc finger domain

pfam12269
Location:410 → 644

zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain
NM_028868.3 → NP_083144.1 CXXC-type zinc finger protein 1 isoform 1

See identical proteins and their annotated locations for NP_083144.1

Status: VALIDATED

Source sequence(s)

AC133186

Consensus CDS

CCDS50320.1

UniProtKB/Swiss-Prot

Q9CWW7

UniProtKB/TrEMBL

Q3UIZ4, Q541B1

Related

ENSMUSP00000025444.7, ENSMUST00000025444.8

Conserved Domains (3) summary

pfam02008
Location:166 → 212

zf-CXXC; CXXC zinc finger domain

cd15553
Location:28 → 73

PHD_Cfp1; PHD finger found in CXXC-type zinc finger protein 1 (Cfp1)

pfam12269
Location:406 → 640

zf-CpG_bind_C; CpG binding protein zinc finger C terminal domain