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    Paqr6 progestin and adipoQ receptor family member VI [ Mus musculus (house mouse) ]

    Gene ID: 68957, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Paqr6provided by MGI
    Official Full Name
    progestin and adipoQ receptor family member VIprovided by MGI
    Primary source
    MGI:MGI:1916207
    See related
    Ensembl:ENSMUSG00000041423 AllianceGenome:MGI:1916207
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500001B10Rik
    Summary
    Predicted to enable signaling receptor activity. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including gut; lung; pharyngo-tympanic tube; ventricular layer; and vibrissa. Orthologous to human PAQR6 (progestin and adipoQ receptor family member 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cerebellum adult (RPKM 11.5), ovary adult (RPKM 8.9) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 F1; 3 38.81 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88271376..88275848)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88364072..88368541)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 79 Neighboring gene SMG5 nonsense mediated mRNA decay factor Neighboring gene bone gamma-carboxyglutamate protein 3 Neighboring gene predicted gene, 21956

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. Tang YT, et al. J Mol Evol, 2005 Sep. PMID 16044242
    2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    membrane progestin receptor delta
    Names
    mPR delta
    membrane progesterone P4 receptor delta
    membrane progesterone receptor delta
    progesterone and adipoQ receptor family member 6
    progestin and adipoQ receptor family member 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310597.1 → NP_001297526.1  membrane progestin receptor delta isoform 2

      See identical proteins and their annotated locations for NP_001297526.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in its central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK139144, BE996278
      Consensus CDS
      CCDS79941.1
      UniProtKB/TrEMBL
      D3Z1S5
      Related
      ENSMUSP00000119656.2, ENSMUST00000147948.8
      Conserved Domains (1) summary
      cl03831
      Location:71 → 161
      HlyIII; Haemolysin-III related

    2. NM_001404108.1 → NP_001391037.1  membrane progestin receptor delta isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC102388
      UniProtKB/Swiss-Prot
      Q3UTT0, Q6TCG5, Q8CF56
      UniProtKB/TrEMBL
      Q0VBT6

    3. NM_001404109.1 → NP_001391038.1  membrane progestin receptor delta isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC102388

    4. NM_001404110.1 → NP_001391039.1  membrane progestin receptor delta isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC102388

    5. NM_198410.3 → NP_940802.1  membrane progestin receptor delta isoform 1

      See identical proteins and their annotated locations for NP_940802.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI607833, AK139144
      Consensus CDS
      CCDS17471.1
      UniProtKB/Swiss-Prot
      Q3UTT0, Q6TCG5, Q8CF56
      UniProtKB/TrEMBL
      Q0VBT6
      Related
      ENSMUSP00000114166.2, ENSMUST00000147991.2
      Conserved Domains (1) summary
      pfam03006
      Location:43 → 271
      HlyIII; Haemolysin-III related

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      88271376..88275848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502009.5 → XP_006502072.1  membrane progestin receptor delta isoform X2

      Conserved Domains (1) summary
      pfam03006
      Location:58 → 311
      HlyIII; Haemolysin-III related

    2. XM_006502010.3 → XP_006502073.1  membrane progestin receptor delta isoform X3

      See identical proteins and their annotated locations for XP_006502073.1

      Conserved Domains (1) summary
      pfam03006
      Location:43 → 296
      HlyIII; Haemolysin-III related
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6TCG5.1 GenPept UniProtKB/Swiss-Prot:Q6TCG5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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