Osbpl11 oxysterol binding protein-like 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Osbpl11provided by MGI
Official Full Name: oxysterol binding protein-like 11provided by MGI
Primary source: MGI:MGI:2146553
See related: Ensembl:ENSMUSG00000022807 AllianceGenome:MGI:2146553
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ORP-11; 9430097N02Rik
Summary: Predicted to enable sterol binding activity and sterol transporter activity. Predicted to be involved in fat cell differentiation and positive regulation of sequestering of triglyceride. Predicted to act upstream of or within lipid transport. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in cytosol; intracellular membrane-bounded organelle; and membrane. Is expressed in several structures, including central nervous system; genitourinary system; heart; immune system; and lung. Orthologous to human OSBPL11 (oxysterol binding protein like 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 10.9), thymus adult (RPKM 8.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B3; 16 23.71 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (33005441..33063682)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (33169763..33243312)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ORP-11 knockdown abrogated the protective action of Bis(Monoacylglycero) Phosphate against oxidized low density lipoprotein induced apoptosis.
Title: Bis(monoacylglycero)phosphate regulates oxysterol binding protein-related protein 11 dependent sterol trafficking.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136289 (e-PCR)
- UniSTS:210282

AI132306 (e-PCR)
- UniSTS:180893

NoName (e-PCR)
- UniSTS:237488

NoName (e-PCR)
- UniSTS:237490

Osbpl11 (e-PCR), detects polymorphism
- UniSTS:265469

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables sterol binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of sequestering of triglyceride	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: oxysterol-binding protein-related protein 11

Names: OSBP-related protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_176840.3 → NP_789810.2 oxysterol-binding protein-related protein 11

See identical proteins and their annotated locations for NP_789810.2

Status: VALIDATED

Source sequence(s)

AC124195, AC145198

Consensus CDS

CCDS28128.1

UniProtKB/TrEMBL

A0A338P6F2, G5E8A0

Related

ENSMUSP00000039632.9, ENSMUST00000039733.10

Conserved Domains (3) summary

cd13291
Location:72 → 178

PH_ORP10_ORP11; Human Oxysterol binding protein (OSBP) related proteins 10 and 11 (ORP10 and ORP11) Pleckstrin homology (PH) domain

pfam00169
Location:74 → 164

PH; PH domain

pfam01237
Location:383 → 743

Oxysterol_BP; Oxysterol-binding protein