Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Adamts2 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2 [ Mus musculus (house mouse) ]

    Gene ID: 216725, updated on 13-Jul-2021

    Summary

    Official Symbol
    Adamts2provided by MGI
    Official Full Name
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2provided by MGI
    Primary source
    MGI:MGI:1347356
    See related
    Ensembl:ENSMUSG00000036545
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    hP; pNPI; ADAM-; PCINP; PC I-NP; ADAM-TS2; ADAMTS-2; ADAM-TS 2
    Summary
    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin repeats) family of proteinases that is involved in the proteolytic processing of procollagens. The encoded protein precursor is proteolytically processed to generate a mature, zinc-dependent enzyme. Mice lacking the encoded protein develop abnormal lungs, fragile skin and male sterility. [provided by RefSeq, Aug 2015]
    Expression
    Biased expression in ovary adult (RPKM 48.4), subcutaneous fat pad adult (RPKM 22.7) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Adamts2 in Genome Data Viewer
    Location:
    11; 11 B1.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50492912..50698400)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50602085..50807573)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (50415587..50617551)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118567937 Neighboring gene predicted gene, 36763 Neighboring gene predicted gene 12198 Neighboring gene uncharacterized LOC118567940 Neighboring gene predicted gene, 39819 Neighboring gene predicted gene 12199 Neighboring gene predicted gene, 51860 Neighboring gene zinc finger protein 354C Neighboring gene zinc finger protein 879

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4060, 4732482M10, A430089F14

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within collagen catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within collagen fibril organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 2
    Names
    a disintegrin and metalloproteinase with thrombospondin repeats
    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2
    procollagen I/II amino propeptide-processing enzyme
    procollagen N-endopeptidase
    procollagen N-proteinase
    NP_783574.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175643.3NP_783574.1  A disintegrin and metalloproteinase with thrombospondin motifs 2 preproprotein

      See identical proteins and their annotated locations for NP_783574.1

      Status: REVIEWED

      Source sequence(s)
      AK040370, AL627215, AL645611, AL645639, CJ068037
      Consensus CDS
      CCDS24636.1
      UniProtKB/Swiss-Prot
      Q8C9W3
      Related
      ENSMUSP00000040171.9, ENSMUST00000040523.9
      Conserved Domains (6) summary
      smart00209
      Location:565617
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:267468
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01421
      Location:269471
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:99210
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:724838
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam08686
      Location:10641094
      PLAC; PLAC (protease and lacunin) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      50492912..50698400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001277305.1: Suppressed sequence

      Description
      NM_001277305.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Support Center