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    Slc4a8 solute carrier family 4 (anion exchanger), member 8 [ Mus musculus (house mouse) ]

    Gene ID: 59033, updated on 23-Jun-2021

    Summary

    Official Symbol
    Slc4a8provided by MGI
    Official Full Name
    solute carrier family 4 (anion exchanger), member 8provided by MGI
    Primary source
    MGI:MGI:1928745
    See related
    Ensembl:ENSMUSG00000023032
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NDCB; KNBC-; NDCBE; kNBC-3; AW493845; C230026C11
    Expression
    Broad expression in frontal lobe adult (RPKM 7.6), cortex adult (RPKM 7.4) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc4a8 in Genome Data Viewer
    Location:
    15; 15 F1
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100659628..100721852)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100761747..100823971)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (100592178..100654402)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene polypeptide N-acetylgalactosaminyltransferase 6, opposite strand Neighboring gene polypeptide N-acetylgalactosaminyltransferase 6 Neighboring gene RIKEN cDNA I730030J21 gene Neighboring gene predicted gene, 52175 Neighboring gene predicted gene, 41401 Neighboring gene predicted gene, 35569 Neighboring gene sodium channel, voltage-gated, type VIII, alpha Neighboring gene predicted gene, 52176

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables anion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables anion:anion antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables bicarbonate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chloride transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables inorganic anion exchanger activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sodium ion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sodium:bicarbonate symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables sodium:bicarbonate symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in anion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bicarbonate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in bicarbonate transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chloride transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryo development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of intracellular pH IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of intracellular pH ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in asymmetric synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glial cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in hippocampal mossy fiber ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in symmetric synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    electroneutral sodium bicarbonate exchanger 1
    Names
    electroneutral Na+-driven Cl-HCO3 exchanger
    k-NBC3
    solute carrier family 4 member 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347102.1NP_001334031.1  electroneutral sodium bicarbonate exchanger 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113587, AK141910, AK171610, BP759706
      Consensus CDS
      CCDS84193.1
      UniProtKB/Swiss-Prot
      Q8JZR6
      UniProtKB/TrEMBL
      Q3UR07
      Related
      ENSMUSP00000125090.2, ENSMUST00000162049.2
      Conserved Domains (1) summary
      cl26877
      Location:65951
      Band_3_cyto; Band 3 cytoplasmic domain
    2. NM_021530.2NP_067505.2  electroneutral sodium bicarbonate exchanger 1 isoform 1

      See identical proteins and their annotated locations for NP_067505.2

      Status: VALIDATED

      Source sequence(s)
      AC113587, AK173014, BB626223, BB851903, BP759706
      Consensus CDS
      CCDS37214.1
      UniProtKB/Swiss-Prot
      Q8JZR6
      Related
      ENSMUSP00000023776.7, ENSMUST00000023776.13
      Conserved Domains (3) summary
      TIGR00834
      Location:1171003
      ae; anion exchange protein
      pfam00955
      Location:443956
      HCO3_cotransp; HCO3- transporter family
      pfam07565
      Location:145402
      Band_3_cyto; Band 3 cytoplasmic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      100659628..100721852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316718.2XP_017172207.1  electroneutral sodium bicarbonate exchanger 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8JZR6
      Conserved Domains (1) summary
      cl26877
      Location:65951
      Band_3_cyto; Band 3 cytoplasmic domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033218.1: Suppressed sequence

      Description
      NM_001033218.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
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