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    Grn granulin [ Mus musculus (house mouse) ]

    Gene ID: 14824, updated on 28-Jun-2021

    Summary

    Official Symbol
    Grnprovided by MGI
    Official Full Name
    granulinprovided by MGI
    Primary source
    MGI:MGI:95832
    See related
    Ensembl:ENSMUSG00000034708
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P; pr; GP88; PEPI; Pgrn; epit; PCDGF; epithelin
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 113.5), ovary adult (RPKM 110.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Grn in Genome Data Viewer
    Location:
    11 D; 11 66.29 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102321333..102327635)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102430507..102436809)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (102291636..102298123)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RUN domain containing 3A Neighboring gene solute carrier family 25, member 39 Neighboring gene microRNA 6930 Neighboring gene family with sequence similarity 171, member A2 Neighboring gene integrin alpha 2b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in astrocyte activation involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blastocyst hatching IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chondrocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryo implantation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within locomotory exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lysosomal lumen acidification ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lysosomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lysosomal transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lysosomal transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lysosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in male mating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microglial cell activation involved in immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of microglial cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neutrophil activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of respiratory burst involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of aspartic-type peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of aspartic-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inflammatory response to wounding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of lysosome organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of lysosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein folding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within regulation of lysosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to estradiol ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space HDA PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    progranulin
    Names
    PC cell-derived growth factor
    acrogranin
    acrogranulin
    epithelin/granulin
    glycoprotein 88
    glycoprotein of 88 Kda
    granulins
    proepithelin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008175.5NP_032201.3  progranulin precursor

      Status: VALIDATED

      Source sequence(s)
      AK018744, AK152705, AW456643
      Related
      ENSMUSP00000159379.2, ENSMUST00000239431.2
      Conserved Domains (1) summary
      smart00277
      Location:283333
      GRAN; Granulin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      102321333..102327635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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