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    Ralgapb Ral GTPase activating protein, beta subunit (non-catalytic) [ Mus musculus (house mouse) ]

    Gene ID: 228850, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ralgapbprovided by MGI
    Official Full Name
    Ral GTPase activating protein, beta subunit (non-catalytic)provided by MGI
    Primary source
    MGI:MGI:2444531
    See related
    Ensembl:ENSMUSG00000027652 AllianceGenome:MGI:2444531
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p170; B230339M05Rik
    Summary
    Enables GTPase activator activity. Acts upstream of or within several processes, including Ral protein signal transduction; activation of GTPase activity; and regulation of exocyst localization. Predicted to be located in cytosol. Is expressed in central nervous system and retina. Orthologous to human RALGAPB (Ral GTPase activating protein non-catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 10.3), whole brain E14.5 (RPKM 9.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 H1; 2 78.72 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (158251722..158341173)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (158409830..158499253)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7878 Neighboring gene small nucleolar RNA host gene 11 Neighboring gene predicted gene, 25187 Neighboring gene predicted gene, 25129 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:158235029-158235212 Neighboring gene STARR-seq mESC enhancer starr_06233 Neighboring gene predicted gene 14200 Neighboring gene predicted gene, 54127 Neighboring gene adipogenin Neighboring gene Rho GTPase activating protein 40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RalA controls glucose homeostasis by regulating glucose uptake in brown fat. Skorobogatko Y, et al. Proc Natl Acad Sci U S A, 2018 Jul 24. PMID 29915037, Free PMC Article
    2. A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action. Chen XW, et al. Mol Biol Cell, 2011 Jan 1. PMID 21148297, Free PMC Article
    3. Annotation and analysis of 10,000 expressed sequence tags from developing mouse eye and adult retina. Yu J, et al. Genome Biol, 2003. PMID 14519200, Free PMC Article
    4. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809
    5. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1219, 9330195P16

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Ral protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within activation of GTPase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of exocyst localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    ral GTPase-activating protein subunit beta
    Names
    ral GTPase-activating protein beta subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291137.1 → NP_001278066.1  ral GTPase-activating protein subunit beta isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AI836674, AL663091, AL844513, CJ119771
      Consensus CDS
      CCDS71178.1
      UniProtKB/TrEMBL
      B2RRF1, E9Q0J2
      Related
      ENSMUSP00000105111.3, ENSMUST00000109485.9
      Conserved Domains (1) summary
      pfam10428
      Location:354 → 427
      SOG2; RAM signalling pathway protein

    2. NM_001291138.1 → NP_001278067.1  ral GTPase-activating protein subunit beta isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AI836674, AL663091, AL844513, CJ119771
      Consensus CDS
      CCDS71179.1
      UniProtKB/TrEMBL
      A2ACC6, B2RRF1
      Related
      ENSMUSP00000105112.3, ENSMUST00000109486.9
      Conserved Domains (1) summary
      pfam10428
      Location:354 → 427
      SOG2; RAM signalling pathway protein

    3. NM_001363006.1 → NP_001349935.1  ral GTPase-activating protein subunit beta isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AL663091, AL844513
      UniProtKB/TrEMBL
      B2RRF1

    4. NM_001369183.1 → NP_001356112.1  ral GTPase-activating protein subunit beta isoform d

      Status: VALIDATED

      Source sequence(s)
      AL663091, AL844513
      UniProtKB/TrEMBL
      A2ACC7
      Related
      ENSMUSP00000116481.2, ENSMUST00000141497.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      158251722..158341173
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499359.5 → XP_006499422.1  ral GTPase-activating protein subunit beta isoform X2

      UniProtKB/TrEMBL
      B2RRF1
      Conserved Domains (1) summary
      pfam10428
      Location:354 → 427
      SOG2; RAM signalling pathway protein

    2. XM_006499361.5 → XP_006499424.1  ral GTPase-activating protein subunit beta isoform X3

      UniProtKB/TrEMBL
      B2RRF1
      Conserved Domains (1) summary
      pfam10428
      Location:354 → 427
      SOG2; RAM signalling pathway protein

    3. XM_006499357.5 → XP_006499420.1  ral GTPase-activating protein subunit beta isoform X1

      See identical proteins and their annotated locations for XP_006499420.1

      UniProtKB/TrEMBL
      B2RRF1
      Conserved Domains (1) summary
      pfam10428
      Location:354 → 427
      SOG2; RAM signalling pathway protein

    4. XM_006499363.5 → XP_006499426.1  ral GTPase-activating protein subunit beta isoform X5

      UniProtKB/TrEMBL
      B2RRF1
      Conserved Domains (1) summary
      pfam10428
      Location:354 → 427
      SOG2; RAM signalling pathway protein

    5. XM_036161598.1 → XP_036017491.1  ral GTPase-activating protein subunit beta isoform X7

      UniProtKB/TrEMBL
      B2RRF1

    6. XM_006499362.5 → XP_006499425.1  ral GTPase-activating protein subunit beta isoform X4

      UniProtKB/TrEMBL
      B2RRF1
      Conserved Domains (1) summary
      pfam10428
      Location:354 → 427
      SOG2; RAM signalling pathway protein

    7. XM_011239490.4 → XP_011237792.1  ral GTPase-activating protein subunit beta isoform X6

      UniProtKB/TrEMBL
      B2RRF1, F8WHN4
      Related
      ENSMUSP00000048430.6, ENSMUST00000046274.12
      Conserved Domains (1) summary
      pfam10428
      Location:354 → 427
      SOG2; RAM signalling pathway protein

    8. XM_011239491.4 → XP_011237793.1  ral GTPase-activating protein subunit beta isoform X9

      Conserved Domains (1) summary
      pfam10428
      Location:354 → 427
      SOG2; RAM signalling pathway protein

    9. XM_017317885.3 → XP_017173374.1  ral GTPase-activating protein subunit beta isoform X8

      UniProtKB/TrEMBL
      B2RRF1

    10. XM_006499358.2 → XP_006499421.1  ral GTPase-activating protein subunit beta isoform X1

      See identical proteins and their annotated locations for XP_006499421.1

      UniProtKB/TrEMBL
      B2RRF1
      Conserved Domains (1) summary
      pfam10428
      Location:354 → 427
      SOG2; RAM signalling pathway protein

    RNA

    1. XR_004940148.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177227.2: Suppressed sequence

      Description
      NM_177227.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_177658.3: Suppressed sequence

      Description
      NM_177658.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BQZ4.2 GenPept UniProtKB/Swiss-Prot:Q8BQZ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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