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    Togaram1 TOG array regulator of axonemal microtubules 1 [ Mus musculus (house mouse) ]

    Gene ID: 328108, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Togaram1provided by MGI
    Official Full Name
    TOG array regulator of axonemal microtubules 1provided by MGI
    Primary source
    MGI:MGI:2684313
    See related
    Ensembl:ENSMUSG00000035614 AllianceGenome:MGI:2684313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam179b; C130034K06; A430041B07Rik
    Summary
    Predicted to enable microtubule binding activity. Involved in positive regulation of microtubule polymerization. Located in ciliary basal body. Colocalizes with microtubule. Human ortholog(s) of this gene implicated in Joubert syndrome. Orthologous to human TOGARAM1 (TOG array regulator of axonemal microtubules 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 5.8), frontal lobe adult (RPKM 3.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Togaram1 in Genome Data Viewer
    Location:
    12 C1; 12 27.21 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (65012350..65069347)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (64965576..65022573)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_32310 Neighboring gene STARR-positive B cell enhancer mm9_chr12:66018613-66018914 Neighboring gene predicted gene, 51965 Neighboring gene predicted gene 527 Neighboring gene kelch-like 28 Neighboring gene STARR-seq mESC enhancer starr_32311 Neighboring gene STARR-positive B cell enhancer ABC_E7138 Neighboring gene predicted gene, 51966 Neighboring gene STARR-seq mESC enhancer starr_32313 Neighboring gene pre-mRNA processing factor 39 Neighboring gene predicted gene, 25970

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Conditional knockout of TOG results in CNS hypomyelination. Maggipinto MJ, et al. Glia, 2017 Mar. PMID 28063167, Free PMC Article
    2. Crescerin uses a TOG domain array to regulate microtubules in the primary cilium. Das A, et al. Mol Biol Cell, 2015 Nov 15. PMID 26378256, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0423, MGC189816, MGC189944, mKIAA0423

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TOG array regulator of axonemal microtubules protein 1
    Names
    crescerin-1
    family with sequence similarity 179, member B
    protein FAM179B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364325.1 → NP_001351254.1  TOG array regulator of axonemal microtubules protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC159621, AC159632
      Consensus CDS
      CCDS88345.1
      UniProtKB/TrEMBL
      A0A1Y7VLS3, B2RXW9
      Related
      ENSMUSP00000152616.2, ENSMUST00000223166.2
      Conserved Domains (2) summary
      sd00044
      Location:395 → 419
      HEAT; HEAT repeat [structural motif]
      pfam15402
      Location:789 → 905
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

    2. NM_177805.3 → NP_808473.2  TOG array regulator of axonemal microtubules protein 1 isoform 2

      See identical proteins and their annotated locations for NP_808473.2

      Status: VALIDATED

      Source sequence(s)
      AC159621, AC159632
      Consensus CDS
      CCDS49075.1
      UniProtKB/Swiss-Prot
      F8WJB2, Q6A070
      UniProtKB/TrEMBL
      B2RXS2, B7ZWL4
      Related
      ENSMUSP00000070382.8, ENSMUST00000066296.9
      Conserved Domains (2) summary
      pfam08192
      Location:957 → 1108
      Peptidase_S64; Peptidase family S64
      sd00044
      Location:395 → 419
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      65012350..65069347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516020.4 → XP_006516083.1  TOG array regulator of axonemal microtubules protein 1 isoform X1

      UniProtKB/TrEMBL
      B2RXW9
      Conserved Domains (2) summary
      sd00044
      Location:395 → 419
      HEAT; HEAT repeat [structural motif]
      pfam15402
      Location:799 → 915
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

    2. XM_006516022.4 → XP_006516085.1  TOG array regulator of axonemal microtubules protein 1 isoform X2

      UniProtKB/TrEMBL
      B2RXS2, B7ZWL4
      Conserved Domains (2) summary
      sd00044
      Location:395 → 419
      HEAT; HEAT repeat [structural motif]
      pfam15402
      Location:799 → 915
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

    3. XM_036157506.1 → XP_036013399.1  TOG array regulator of axonemal microtubules protein 1 isoform X3

      UniProtKB/TrEMBL
      B2RXW9
      Conserved Domains (2) summary
      sd00044
      Location:395 → 419
      HEAT; HEAT repeat [structural motif]
      pfam15402
      Location:799 → 915
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

    4. XM_006516023.4 → XP_006516086.1  TOG array regulator of axonemal microtubules protein 1 isoform X4

      UniProtKB/TrEMBL
      B2RXW9
      Conserved Domains (2) summary
      sd00044
      Location:395 → 419
      HEAT; HEAT repeat [structural motif]
      pfam15402
      Location:799 → 915
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

    5. XM_017315119.2 → XP_017170608.1  TOG array regulator of axonemal microtubules protein 1 isoform X5

      Conserved Domains (2) summary
      sd00044
      Location:395 → 419
      HEAT; HEAT repeat [structural motif]
      pfam15402
      Location:799 → 915
      Spc7_N; N-terminus of kinetochore NMS complex subunit Spc7

    RNA

    1. XR_004937521.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6A070.3 GenPept UniProtKB/Swiss-Prot:Q6A070

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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