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    Zfp69 zinc finger protein 69 [ Mus musculus (house mouse) ]

    Gene ID: 381549, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp69provided by MGI
    Official Full Name
    zinc finger protein 69provided by MGI
    Primary source
    MGI:MGI:107794
    See related
    Ensembl:ENSMUSG00000064141 AllianceGenome:MGI:107794
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Krab2; Zfp63; Gm1029
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in regulation of lipid metabolic process. Located in nucleus. Is expressed in several structures, including branchial arch; early conceptus; heart; and ovary. Orthologous to human ZFP69 (ZFP69 zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 1.2), limb E14.5 (RPKM 0.9) and 28 other tissues See more
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    Genomic context

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    See Zfp69 in Genome Data Viewer
    Location:
    4 D2.2; 4 56.66 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (120786201..120808898, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (120930133..120951701, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11258 Neighboring gene predicted gene, 24678 Neighboring gene STARR-positive B cell enhancer ABC_E10254 Neighboring gene STARR-positive B cell enhancer ABC_E6207 Neighboring gene exonuclease 5 Neighboring gene STARR-positive B cell enhancer ABC_E6208 Neighboring gene STARR-positive B cell enhancer ABC_E4659 Neighboring gene small ArfGAP 2 Neighboring gene microRNA 7015 Neighboring gene STARR-positive B cell enhancer ABC_E6209 Neighboring gene STARR-positive B cell enhancer ABC_E3508 Neighboring gene STARR-positive B cell enhancer ABC_E10255 Neighboring gene STARR-positive B cell enhancer ABC_E6210 Neighboring gene STARR-seq mESC enhancer starr_11259 Neighboring gene collagen, type IX, alpha 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Role of zinc finger transcription factor zfp69 in body fat storage and diabetes susceptibility of mice. Scherneck S, et al. Results Probl Cell Differ, 2010. PMID 20865372
    2. Genetic background (DDD/Sgn versus C57BL/6J) strongly influences postnatal growth of male mice carrying the A(y) allele at the agouti locus: identification of quantitative trait loci associated with diabetes and body weight loss. Suto J, et al. BMC Genet, 2013 May 4. PMID 23641944, Free PMC Article
    3. Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL. Scherneck S, et al. PLoS Genet, 2009 Jul. PMID 19578398, Free PMC Article
    4. The diabetes gene Zfp69 modulates hepatic insulin sensitivity in mice. Chung B, et al. Diabetologia, 2015 Oct. PMID 26232096, Free PMC Article
    5. Mouse ES cell-derived cardiac precursor cells are multipotent and facilitate identification of novel cardiac genes. Christoforou N, et al. J Clin Invest, 2008 Mar. PMID 18246200, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zfp69 mediates hyperlipidaemia, liver fat accumulation and mild insulin resistance. However, it does not induce type 2 diabetes, suggesting that the diabetogenic effect of the Zfp69 locus requires synergy with other as yet unidentified genes.
      Title: The diabetes gene Zfp69 modulates hepatic insulin sensitivity in mice.
    2. Zfp69 mRNA-expression was significantly higher in diabetic subjects than in unaffected controls.
      Title: Role of zinc finger transcription factor zfp69 in body fat storage and diabetes susceptibility of mice.
    3. Zfp69 is the most likely candidate for the diabetogenic effect of Nidd/SJL locus.
      Title: Positional cloning of zinc finger domain transcription factor Zfp69, a candidate gene for obesity-associated diabetes contributed by mouse locus Nidd/SJL.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 69
    Names
    Zfp63p
    zinc finger protein 642

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005788.3 → NP_001005788.2  zinc finger protein 69 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL731722, BC066020, CK624262
      Consensus CDS
      CCDS18597.2
      UniProtKB/Swiss-Prot
      A2A761
      Related
      ENSMUSP00000101887.2, ENSMUST00000106280.8
      Conserved Domains (5) summary
      smart00349
      Location:131 → 192
      KRAB; krueppel associated box
      smart01104
      Location:52 → 128
      CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
      COG5048
      Location:279 → 510
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:326 → 346
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:534 → 559
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001384119.1 → NP_001371048.1  zinc finger protein 69 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606904, AL731722
      Conserved Domains (5) summary
      smart00349
      Location:131 → 191
      KRAB; krueppel associated box
      smart01104
      Location:52 → 128
      CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
      COG5048
      Location:278 → 509
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:325 → 345
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:533 → 558
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      120786201..120808898 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164209.1 → XP_036020102.1  zinc finger protein 69 isoform X1

      Conserved Domains (5) summary
      smart00349
      Location:131 → 171
      KRAB; krueppel associated box
      smart01104
      Location:52 → 128
      CTD; Spt5 C-terminal nonapeptide repeat binding Spt4
      COG5048
      Location:246 → 477
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:293 → 313
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:501 → 526
      zf-H2C2_2; Zinc-finger double domain

    2. XM_036164211.1 → XP_036020104.1  zinc finger protein 69 isoform X3

      UniProtKB/TrEMBL
      Q6NZQ1
      Conserved Domains (4) summary
      COG5048
      Location:120 → 351
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:167 → 187
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:375 → 400
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:1 → 33
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    3. XM_036164212.1 → XP_036020105.1  zinc finger protein 69 isoform X3

      UniProtKB/TrEMBL
      Q6NZQ1
      Conserved Domains (4) summary
      COG5048
      Location:120 → 351
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:167 → 187
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:375 → 400
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:1 → 33
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    4. XM_036164210.1 → XP_036020103.1  zinc finger protein 69 isoform X2

      Conserved Domains (4) summary
      smart00349
      Location:12 → 73
      KRAB; krueppel associated box
      COG5048
      Location:160 → 391
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:207 → 227
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:415 → 440
      zf-H2C2_2; Zinc-finger double domain

    5. XM_017320292.2 → XP_017175781.1  zinc finger protein 69 isoform X3

      UniProtKB/TrEMBL
      Q6NZQ1
      Conserved Domains (4) summary
      COG5048
      Location:120 → 351
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:167 → 187
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:375 → 400
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:1 → 33
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    6. XM_006503211.4 → XP_006503274.1  zinc finger protein 69 isoform X4

      See identical proteins and their annotated locations for XP_006503274.1

      Conserved Domains (3) summary
      COG5048
      Location:88 → 319
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:135 → 155
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:343 → 368
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2A761.1 GenPept UniProtKB/Swiss-Prot:A2A761

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