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    Mettl5 methyltransferase 5, N6-adenosine [ Mus musculus (house mouse) ]

    Gene ID: 75422, updated on 28-Apr-2024

    Summary

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    Official Symbol
    Mettl5provided by MGI
    Official Full Name
    methyltransferase 5, N6-adenosineprovided by MGI
    Primary source
    MGI:MGI:1922672
    See related
    Ensembl:ENSMUSG00000051730 AllianceGenome:MGI:1922672
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810410A08Rik
    Summary
    Enables rRNA (adenine-N6-)-methyltransferase activity. Involved in positive regulation of translation; rRNA methylation; and stem cell differentiation. Predicted to be located in nucleus; postsynapse; and presynapse. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder-72. Orthologous to human METTL5 (methyltransferase 5, N6-adenosine). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 10.1), CNS E11.5 (RPKM 8.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 C2; 2 40.95 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (69701539..69717961, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (69871195..69886634, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39841 Neighboring gene STARR-positive B cell enhancer mm9_chr2:69698414-69698714 Neighboring gene STARR-positive B cell enhancer ABC_E4462 Neighboring gene kelch-like 23 Neighboring gene STARR-positive B cell enhancer ABC_E11134 Neighboring gene STARR-seq mESC enhancer starr_04746 Neighboring gene STARR-positive B cell enhancer ABC_E508 Neighboring gene STARR-seq mESC enhancer starr_04748 Neighboring gene small RNA binding exonuclease protection factor La Neighboring gene STARR-positive B cell enhancer ABC_E9515 Neighboring gene STARR-seq mESC enhancer starr_04749 Neighboring gene ubiquitin protein ligase E3 component n-recognin 3 Neighboring gene STARR-seq mESC enhancer starr_04750 Neighboring gene STARR-positive B cell enhancer ABC_E4463 Neighboring gene myosin IIIB Neighboring gene STARR-seq mESC enhancer starr_04751 Neighboring gene STARR-seq mESC enhancer starr_04752 Neighboring gene STARR-seq mESC enhancer starr_04756 Neighboring gene STARR-seq mESC enhancer starr_04757

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibition of METTL5 improves preimplantation development of mouse somatic cell nuclear transfer embryos. Zhang L, et al. Reproduction, 2022 Nov 1. PMID 36111643
    2. Loss of m(6)A Methyltransferase METTL5 Promotes Cardiac Hypertrophy Through Epitranscriptomic Control of SUZ12 Expression. Han Y, et al. Front Cardiovasc Med, 2022. PMID 35295259, Free PMC Article
    3. The 18S rRNA m(6) A methyltransferase METTL5 promotes mouse embryonic stem cell differentiation. Xing M, et al. EMBO Rep, 2020 Oct 5. PMID 32783360, Free PMC Article
    4. The rRNA m(6)A methyltransferase METTL5 is involved in pluripotency and developmental programs. Ignatova VV, et al. Genes Dev, 2020 May 1. PMID 32217665, Free PMC Article
    5. The METTL5-TRMT112 N(6)-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation. Sepich-Poore C, et al. J Biol Chem, 2022 Mar. PMID 35033535, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. METTL5-mediated 18S rRNA m[6]A modification promotes oncogenic mRNA translation and intrahepatic cholangiocarcinoma progression.
      Title: METTL5-mediated 18S rRNA m(6)A modification promotes oncogenic mRNA translation and intrahepatic cholangiocarcinoma progression.
    2. Inhibition of METTL5 improves preimplantation development of mouse somatic cell nuclear transfer embryos.
      Title: Inhibition of METTL5 improves preimplantation development of mouse somatic cell nuclear transfer embryos.
    3. The 18S rRNA m(6) A methyltransferase METTL5 promotes mouse embryonic stem cell differentiation.
      Title: The 18S rRNA m(6) A methyltransferase METTL5 promotes mouse embryonic stem cell differentiation.
    4. The rRNA m(6)A methyltransferase METTL5 is involved in pluripotency and developmental programs.
      Title: The rRNA m(6)A methyltransferase METTL5 is involved in pluripotency and developmental programs.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (8)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables S-adenosyl-L-methionine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (adenine-N6-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA (adenine-N6-)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA (adenine-N6-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rRNA N6-adenosine-methyltransferase METTL5
    Names
    methyltransferase like 5
    methyltransferase-like protein 5
    NP_083556.2
    XP_006500392.1
    XP_030108023.1
    XP_036018540.1
    XP_036018541.1
    XP_036018542.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029280.4 → NP_083556.2  rRNA N6-adenosine-methyltransferase METTL5

      See identical proteins and their annotated locations for NP_083556.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.
      Source sequence(s)
      AA175151, AA466649, AK013063, AK133594
      Consensus CDS
      CCDS16103.2
      UniProtKB/Swiss-Prot
      Q8K1A0
      Related
      ENSMUSP00000050907.7, ENSMUST00000060447.13
      Conserved Domains (1) summary
      COG2263
      Location:7 → 209
      COG2263; Predicted RNA methylase [General function prediction only]

    RNA

    1. NR_110977.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA175151, AA466649, AK013063, AK133594

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      69701539..69717961 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162649.1 → XP_036018542.1  rRNA N6-adenosine-methyltransferase METTL5 isoform X4

      UniProtKB/TrEMBL
      D6RCI3, Q3UZW4
      Related
      ENSMUSP00000121474.2, ENSMUST00000142127.8
      Conserved Domains (1) summary
      cl17173
      Location:7 → 136
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_036162648.1 → XP_036018541.1  rRNA N6-adenosine-methyltransferase METTL5 isoform X3

      UniProtKB/TrEMBL
      Q3UZW4
      Conserved Domains (1) summary
      cl17173
      Location:7 → 167
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. XM_030252163.2 → XP_030108023.1  rRNA N6-adenosine-methyltransferase METTL5 isoform X2

      UniProtKB/Swiss-Prot
      Q8K1A0
      Conserved Domains (1) summary
      COG2263
      Location:7 → 209
      COG2263; Predicted RNA methylase [General function prediction only]

    4. XM_006500329.5 → XP_006500392.1  rRNA N6-adenosine-methyltransferase METTL5 isoform X1

      Conserved Domains (1) summary
      COG2263
      Location:7 → 204
      COG2263; Predicted RNA methylase [General function prediction only]

    5. XM_036162647.1 → XP_036018540.1  rRNA N6-adenosine-methyltransferase METTL5 isoform X1

      Conserved Domains (1) summary
      COG2263
      Location:7 → 204
      COG2263; Predicted RNA methylase [General function prediction only]

    RNA

    1. XR_004940759.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K1A0.2 GenPept UniProtKB/Swiss-Prot:Q8K1A0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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