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    Blvra biliverdin reductase A [ Mus musculus (house mouse) ]

    Gene ID: 109778, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Blvraprovided by MGI
    Official Full Name
    biliverdin reductase Aprovided by MGI
    Primary source
    MGI:MGI:88170
    See related
    Ensembl:ENSMUSG00000001999 AllianceGenome:MGI:88170
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Blvr; 0610006A11Rik; 2500001N03Rik
    Summary
    Enables biliverdin reductase (NAD(P)+) activity. Predicted to be involved in heme catabolic process. Predicted to be located in cytosol. Is expressed in decidua; myometrium; placenta; and spongiotrophoblast. Orthologous to human BLVRA (biliverdin reductase A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 12.0), bladder adult (RPKM 10.9) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    2 F1; 2 61.76 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (126912549..126939004)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (127070629..127097084)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 52496 Neighboring gene STARR-seq mESC enhancer starr_05618 Neighboring gene STARR-positive B cell enhancer ABC_E9531 Neighboring gene adaptor-related protein complex AP-4, epsilon 1 Neighboring gene STARR-seq mESC enhancer starr_05619 Neighboring gene STARR-positive B cell enhancer ABC_E3399 Neighboring gene predicted gene, 31414 Neighboring gene predicted gene, 39922 Neighboring gene non-SMC condensin I complex, subunit H Neighboring gene STARR-positive B cell enhancer ABC_E3400

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Bilirubin deficiency renders mice susceptible to hepatic steatosis in the absence of insulin resistance. Chen W, et al. Redox Biol, 2021 Nov. PMID 34610553, Free PMC Article
    2. Biliverdin Reductase-A Deficiency Brighten and Sensitize Biliverdin-binding Chromoproteins. Kobachi K, et al. Cell Struct Funct, 2020 Aug 21. PMID 32581154, Free PMC Article
    3. Biliverdin Reductase A (BVRA) Knockout in Adipocytes Induces Hypertrophy and Reduces Mitochondria in White Fat of Obese Mice. Stec DE, et al. Biomolecules, 2020 Mar 2. PMID 32131495, Free PMC Article
    4. Absence of the biliverdin reductase-a gene is associated with increased endogenous oxidative stress. Chen W, et al. Free Radic Biol Med, 2018 Feb 1. PMID 29195835
    5. Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm. Barone E, et al. Free Radic Biol Med, 2016 Feb. PMID 26698666

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biliverdin Reductase-A Deficiency Brighten and Sensitize Biliverdin-binding Chromoproteins.
      Title: Biliverdin Reductase-A Deficiency Brighten and Sensitize Biliverdin-binding Chromoproteins.
    2. Biliverdin Reductase A (BVRA) Knockout in Adipocytes Induces Hypertrophy and Reduces Mitochondria in White Fat of Obese Mice.
      Title: Biliverdin Reductase A (BVRA) Knockout in Adipocytes Induces Hypertrophy and Reduces Mitochondria in White Fat of Obese Mice.
    3. macrophages lacking BVR-A are characterized by the expression of M1 polarization-associated chemokines, the levels of which depend in part on C5aR1 signaling.
      Title: Deletion of Biliverdin Reductase A in Myeloid Cells Promotes Chemokine Expression and Chemotaxis in Part via a Complement C5a--C5aR1 Pathway.
    4. BVR-A is potential therapeutic target to prevent brain insulin resistance in Alzheimer's disease.
      Title: Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease.
    5. this study shows that absence of the biliverdin reductase-a gene is associated with increased endogenous oxidative stress
      Title: Absence of the biliverdin reductase-a gene is associated with increased endogenous oxidative stress.
    6. These findings reveal a novel BVRA-GSKbeta-PPARalpha axis that regulates hepatic lipid metabolism and may provide unique targets for the treatment of non-alcoholic fatty liver disease.
      Title: Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α.
    7. BVR-A integrates both oxidative/nitrosative stress- and insulin-mediated signaling, both mechanisms dysregulated in the Alzheimer disease brain.
      Title: Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm.
    8. The biliverdin reductase A positive macrophage is a source of anti-inflammatory cytokine IL-10 in injured kidney.
      Title: Biliverdin Reductase A (BVRA) Mediates Macrophage Expression of Interleukin-10 in Injured Kidney.
    9. Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B.
      Title: Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B.
    10. biliverdin reductase has a role in regulating the inflammatory response to endotoxin that requires eNOS-derived NO and TLR4 signaling in macrophages
      Title: Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (4)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables biliberdin reductase NAD+ activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables biliverdin reductase (NAD(P)H) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables biliverdin reductase (NAD(P)H) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables biliverdin reductase (NAD(P)H) activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables biliverdin reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within heme catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in heme catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    biliverdin reductase A
    Names
    BVR A
    biliverdin-IX alpha-reductase
    NP_080954.4
    XP_006498632.1
    XP_006498634.1
    XP_006498635.1
    XP_006498636.1
    XP_030102511.1
    XP_030102519.1
    XP_036013445.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026678.4 → NP_080954.4  biliverdin reductase A

      See identical proteins and their annotated locations for NP_080954.4

      Status: VALIDATED

      Source sequence(s)
      BC052146, BY073963, CA983696
      Consensus CDS
      CCDS16692.1
      UniProtKB/Swiss-Prot
      Q3T9C6, Q80WR6, Q9CY64, Q9DD21
      Related
      ENSMUSP00000002064.9, ENSMUST00000002064.15
      Conserved Domains (2) summary
      pfam01408
      Location:18 → 121
      GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
      pfam09166
      Location:132 → 242
      Biliv-reduc_cat; Biliverdin reductase, catalytic

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      126912549..126939004
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498573.1 → XP_006498636.1  biliverdin reductase A isoform X3

      Conserved Domains (1) summary
      pfam09166
      Location:34 → 144
      Biliv-reduc_cat; Biliverdin reductase, catalytic

    2. XM_030246659.1 → XP_030102519.1  biliverdin reductase A isoform X3

      Conserved Domains (1) summary
      pfam09166
      Location:34 → 144
      Biliv-reduc_cat; Biliverdin reductase, catalytic

    3. XM_006498571.3 → XP_006498634.1  biliverdin reductase A isoform X2

      See identical proteins and their annotated locations for XP_006498634.1

      UniProtKB/Swiss-Prot
      Q3T9C6, Q80WR6, Q9CY64, Q9DD21
      Conserved Domains (2) summary
      pfam01408
      Location:18 → 121
      GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
      pfam09166
      Location:132 → 242
      Biliv-reduc_cat; Biliverdin reductase, catalytic

    4. XM_030246651.1 → XP_030102511.1  biliverdin reductase A isoform X2

      UniProtKB/Swiss-Prot
      Q3T9C6, Q80WR6, Q9CY64, Q9DD21
      Conserved Domains (2) summary
      pfam01408
      Location:18 → 121
      GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
      pfam09166
      Location:132 → 242
      Biliv-reduc_cat; Biliverdin reductase, catalytic

    5. XM_006498569.4 → XP_006498632.1  biliverdin reductase A isoform X1

      Conserved Domains (2) summary
      pfam01408
      Location:60 → 163
      GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
      pfam09166
      Location:174 → 284
      Biliv-reduc_cat; Biliverdin reductase, catalytic

    6. XM_036157552.1 → XP_036013445.1  biliverdin reductase A isoform X3

      Conserved Domains (1) summary
      pfam09166
      Location:34 → 144
      Biliv-reduc_cat; Biliverdin reductase, catalytic

    7. XM_006498572.5 → XP_006498635.1  biliverdin reductase A isoform X2

      See identical proteins and their annotated locations for XP_006498635.1

      UniProtKB/Swiss-Prot
      Q3T9C6, Q80WR6, Q9CY64, Q9DD21
      Conserved Domains (2) summary
      pfam01408
      Location:18 → 121
      GFO_IDH_MocA; Oxidoreductase family, NAD-binding Rossmann fold
      pfam09166
      Location:132 → 242
      Biliv-reduc_cat; Biliverdin reductase, catalytic
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CY64.1 GenPept UniProtKB/Swiss-Prot:Q9CY64

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