Ptger4 prostaglandin E receptor 4 (subtype EP4) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptger4provided by MGI
Official Full Name: prostaglandin E receptor 4 (subtype EP4)provided by MGI
Primary source: MGI:MGI:104311
See related: Ensembl:ENSMUSG00000039942 AllianceGenome:MGI:104311
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EP4; Ptgerep4
Summary: Predicted to enable prostaglandin E receptor activity. Involved in several processes, including T-helper cell differentiation; regulation of cytokine production; and regulation of stress fiber assembly. Acts upstream of or within several processes, including cellular response to mechanical stimulus; regulation of ossification; and response to lipopolysaccharide. Predicted to be located in neuron projection terminus; neuronal cell body; and nuclear membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system; early conceptus; heart valve; retina; and secondary oocyte. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in ankylosing spondylitis; arteriosclerosis; and ulcerative colitis. Orthologous to human PTGER4 (prostaglandin E receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in small intestine adult (RPKM 27.1), colon adult (RPKM 22.4) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A1; 15 1.99 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (5262880..5273668, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (5233399..5244187, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prostaglandin E2-Induced AKT Activation Regulates the Life Span of Short-Lived Plasma Cells by Attenuating IRE1alpha Hyperactivation.
Title: Prostaglandin E(2)-Induced AKT Activation Regulates the Life Span of Short-Lived Plasma Cells by Attenuating IRE1α Hyperactivation.
Adipocyte-derived PGE2 is required for intermittent fasting-induced Treg proliferation and improvement of insulin sensitivity.
Title: Adipocyte-derived PGE2 is required for intermittent fasting-induced Treg proliferation and improvement of insulin sensitivity.
Intact prostaglandin signaling through EP2 and EP4 receptors in stromal progenitor cells is required for normal development of the renal cortex in mice.
Title: Intact prostaglandin signaling through EP2 and EP4 receptors in stromal progenitor cells is required for normal development of the renal cortex in mice.
Crosstalk between the COX2-PGE2-EP4 signaling pathway and primary cilia in osteoblasts after mechanical stimulation.
Title: Crosstalk between the COX2-PGE2-EP4 signaling pathway and primary cilia in osteoblasts after mechanical stimulation.
Prostaglandin E2-EP4 Axis Promotes Lipolysis and Fibrosis in Adipose Tissue Leading to Ectopic Fat Deposition and Insulin Resistance.
Title: Prostaglandin E(2)-EP4 Axis Promotes Lipolysis and Fibrosis in Adipose Tissue Leading to Ectopic Fat Deposition and Insulin Resistance.
E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis.
Title: E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis.
Prostaglandin E receptor subtype 4 protects against diabetic cardiomyopathy by modulating cardiac fatty acid metabolism via FOXO1/CD36 signalling.
Title: Prostaglandin E receptor subtype 4 protects against diabetic cardiomyopathy by modulating cardiac fatty acid metabolism via FOXO1/CD36 signalling.
Epithelial EP4 plays an essential role in maintaining homeostasis in colon.
Title: Epithelial EP4 plays an essential role in maintaining homeostasis in colon.
EP4 signalling is essential for controlling islet inflammation by causing a shift in macrophage polarization in obesity/type 2 diabetes.
Title: EP4 signalling is essential for controlling islet inflammation by causing a shift in macrophage polarization in obesity/type 2 diabetes.
Studied the role of prostaglandin E receptor 4 (EP4) in pathological vascular remodeling; found EP4 is critical for vascular homeostasis; demonstrated EP4 knockout exacerbates AngII-induced aortic dissection thru inflammation and increased blood pressure.
Title: VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure.

Submit: New GeneRIF Correction See all GeneRIFs (122)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (6)

General gene information

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Markers

RH127164 (e-PCR)
- UniSTS:208477

Ptger4 (e-PCR), detects polymorphism
- UniSTS:498275

SHGC-64757 (e-PCR)
- UniSTS:184204

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin E receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin E receptor activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin E receptor activity	TAS Traceable Author Statement more info	PubMed
enables prostaglandin receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in T-helper cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in bone development	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to prostaglandin E stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemokinesis	ISO Inferred from Sequence Orthology more info
involved_in ductus arteriosus closure	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within interleukin-33 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ductus arteriosus closure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelin production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of eosinophil extravasation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hydrogen peroxide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of integrin activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 alpha production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric-oxide synthase biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of peptide secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of small intestine smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of antral ovarian follicle growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone resorption	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcitonin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circadian sleep/wake cycle, non-REM sleep	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hyaluronan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of matrix metallopeptidase secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mucus secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil extravasation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ovarian follicle development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substance P secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substance P secretion, neurotransmission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of urine volume	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian sleep/wake cycle, wakefulness	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of stress fiber assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to nematode	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection terminus	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prostaglandin E2 receptor EP4 subtype

Names: PGE2 receptor EP4 subtype; prostanoid EP4 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136079.2 → NP_001129551.1 prostaglandin E2 receptor EP4 subtype isoform 1

See identical proteins and their annotated locations for NP_001129551.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 2. The encoded isoform (1) has a shorter N-terminus, compared to isoform 2.

Source sequence(s)

AC135079

Consensus CDS

CCDS49575.1

UniProtKB/TrEMBL

Q3UM94, Q91VE4

Related

ENSMUSP00000112858.2, ENSMUST00000120563.2

Conserved Domains (2) summary

pfam00001
Location:34 → 332

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:29 → 229

7tm_4; Olfactory receptor
NM_008965.2 → NP_032991.1 prostaglandin E2 receptor EP4 subtype isoform 2

See identical proteins and their annotated locations for NP_032991.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) encodes the longer isoform (2).

Source sequence(s)

AC135079

Consensus CDS

CCDS27365.1

UniProtKB/Swiss-Prot

P32240

UniProtKB/TrEMBL

Q3UM94

Related

ENSMUSP00000048736.9, ENSMUST00000047379.15

Conserved Domains (2) summary

pfam00001
Location:59 → 357

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:54 → 254

7tm_4; Olfactory receptor