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    Kcnk9 potassium channel, subfamily K, member 9 [ Mus musculus (house mouse) ]

    Gene ID: 223604, updated on 22-Apr-2024

    Summary

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    Official Symbol
    Kcnk9provided by MGI
    Official Full Name
    potassium channel, subfamily K, member 9provided by MGI
    Primary source
    MGI:MGI:3521816
    See related
    Ensembl:ENSMUSG00000036760 AllianceGenome:MGI:3521816
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Task3; A930009L07Rik
    Summary
    Enables voltage-gated potassium channel activity. Acts upstream of or within potassium ion import across plasma membrane. Predicted to be located in plasma membrane and synaptic vesicle. Predicted to be integral component of plasma membrane. Is expressed in cerebral cortex; early conceptus; and secondary oocyte. Human ortholog(s) of this gene implicated in Birk-Barel syndrome. Orthologous to human KCNK9 (potassium two pore domain channel subfamily K member 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in adrenal adult (RPKM 23.2), cortex adult (RPKM 9.8) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15; 15 D3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (72373722..72422415, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (72501873..72548614, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52221 Neighboring gene predicted gene, 24390 Neighboring gene STARR-positive B cell enhancer ABC_E8594 Neighboring gene STARR-seq mESC enhancer starr_38933 Neighboring gene STARR-seq mESC enhancer starr_38934 Neighboring gene trafficking protein particle complex 9 Neighboring gene predicted gene, 28020 Neighboring gene predicted gene, 53896 Neighboring gene paternally expressed 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tandem pore domain acid-sensitive K channel 3 (TASK-3) regulates visual sensitivity in healthy and aging retina. Wen X, et al. Sci Adv, 2022 Sep 9. PMID 36070380, Free PMC Article
    2. Deficiency of the Two-Pore Potassium Channel KCNK9 Impairs Intestinal Epithelial Cell Survival and Aggravates Dextran Sodium Sulfate-Induced Colitis. Pfeuffer S, et al. Cell Mol Gastroenterol Hepatol, 2022. PMID 35973573, Free PMC Article
    3. A 5' UTR GGN repeat controls localisation and translation of a potassium leak channel mRNA through G-quadruplex formation. Maltby CJ, et al. Nucleic Acids Res, 2020 Sep 25. PMID 32870280, Free PMC Article
    4. Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome. Cooper A, et al. Nat Commun, 2020 Jan 24. PMID 31980599, Free PMC Article
    5. Selective activation of TWIK-related acid-sensitive K(+) 3 subunit-containing channels is analgesic in rodent models. Liao P, et al. Sci Transl Med, 2019 Nov 20. PMID 31748231

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biallelic non-productive enhancer-promoter interactions precede imprinted expression of Kcnk9 during mouse neural commitment.
      Title: Biallelic non-productive enhancer-promoter interactions precede imprinted expression of Kcnk9 during mouse neural commitment.
    2. TWIK-related acid-sensitive potassium channels TASK-1 and TASK-3 may participate in the process of the coexistence of asthma and OSA.
      Title: TWIK-related acid-sensitive potassium channels TASK-1 and TASK-3 may participate in the process of the coexistence of asthma and OSA.
    3. Allelic chromatin structure precedes imprinted expression of Kcnk9 during neurogenesis.
      Title: Allelic chromatin structure precedes imprinted expression of Kcnk9 during neurogenesis.
    4. Deficiency of the Two-Pore Potassium Channel KCNK9 Impairs Intestinal Epithelial Cell Survival and Aggravates Dextran Sodium Sulfate-Induced Colitis.
      Title: Deficiency of the Two-Pore Potassium Channel KCNK9 Impairs Intestinal Epithelial Cell Survival and Aggravates Dextran Sodium Sulfate-Induced Colitis.
    5. Expression of p11 and heteromeric TASK channels in mouse adrenal cortical cells and H295R cells.
      Title: Expression of p11 and heteromeric TASK channels in mouse adrenal cortical cells and H295R cells.
    6. A 5' UTR GGN repeat controls localisation and translation of a potassium leak channel mRNA through G-quadruplex formation.
      Title: A 5' UTR GGN repeat controls localisation and translation of a potassium leak channel mRNA through G-quadruplex formation.
    7. Selective activation of TWIK-related acid-sensitive K(+) 3 subunit-containing channels is analgesic in rodent models.
      Title: Selective activation of TWIK-related acid-sensitive K(+) 3 subunit-containing channels is analgesic in rodent models.
    8. TASK-1 and TASK-3 strongly affect the development of pressure overload cardiomyopathies in genetic models of TASK-1 and TASK-3 loss of function.
      Title: TASK-1 and TASK-3 channels modulate pressure overload-induced cardiac remodeling and dysfunction.
    9. Mutations in the actively expressed, maternal allele of the imprinted KCNK9 gene cause Birk-Barel intellectual disability syndrome (BBIDS). Using a BBIDS mouse model, we identify here a partial rescue of the BBIDS-like behavioral and neuronal phenotypes mediated via residual expression from the paternal Kcnk9 (Kcnk9(pat)) allele.
      Title: Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome.
    10. deleted TASK-1 and TASK-3 channels selectively from zona glomerulosa cells and generated a model of mild aldosterone autonomy with attendant hypertension that is aldosterone-driven and Ang II (angiotensin II)-independent.
      Title: Adrenal Tissue-Specific Deletion of TASK Channels Causes Aldosterone-Driven Angiotensin II-Independent Hypertension.
    Submit: New GeneRIF Correction See all GeneRIFs (31)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within potassium ion import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stabilization of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    potassium channel subfamily K member 9
    Names
    TWIK-related acid-sensitive K(+) channel 3
    acid-sensitive potassium channel protein TASK-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033876.2 → NP_001029048.1  potassium channel subfamily K member 9 precursor

      See identical proteins and their annotated locations for NP_001029048.1

      Status: VALIDATED

      Source sequence(s)
      AC118008, AC161195
      Consensus CDS
      CCDS27515.1
      UniProtKB/Swiss-Prot
      B2RT82, Q3LS21
      Related
      ENSMUSP00000038729.7, ENSMUST00000044624.8
      Conserved Domains (1) summary
      pfam07885
      Location:77 → 132
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      72373722..72422415 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520768.5 → XP_006520831.1  potassium channel subfamily K member 9 isoform X1

      Conserved Domains (1) summary
      pfam07885
      Location:279 → 334
      Ion_trans_2; Ion channel

    2. XM_036159328.1 → XP_036015221.1  potassium channel subfamily K member 9 isoform X1

      Conserved Domains (1) summary
      pfam07885
      Location:279 → 334
      Ion_trans_2; Ion channel
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3LS21.1 GenPept UniProtKB/Swiss-Prot:Q3LS21

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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