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    Gstt2 glutathione S-transferase, theta 2 [ Mus musculus (house mouse) ]

    Gene ID: 14872, updated on 23-Jun-2021

    Summary

    Official Symbol
    Gstt2provided by MGI
    Official Full Name
    glutathione S-transferase, theta 2provided by MGI
    Primary source
    MGI:MGI:106188
    See related
    Ensembl:ENSMUSG00000033318
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Y; Yrs; mGSTT; mGSTT2; AI266894
    Expression
    Broad expression in kidney adult (RPKM 150.6), liver adult (RPKM 57.5) and 19 other tissues See more
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    Genomic context

    See Gstt2 in Genome Data Viewer
    Location:
    10 C1; 10 38.58 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75667676..75673253, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75831842..75837419, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (75294590..75297626, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase, theta 1 Neighboring gene glutathione S-transferase, theta 4 Neighboring gene predicted gene, 40697 Neighboring gene macrophage migration inhibitory factor (glycosylation-inhibiting factor)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    glutathione S-transferase theta-2
    Names
    GST class-theta-2
    NP_034491.2
    XP_006513303.1
    XP_006513304.1
    XP_011241675.1
    XP_030100749.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010361.2NP_034491.2  glutathione S-transferase theta-2

      See identical proteins and their annotated locations for NP_034491.2

      Status: VALIDATED

      Source sequence(s)
      AK158939, BU938629
      Consensus CDS
      CCDS48601.1
      UniProtKB/Swiss-Prot
      Q61133
      Related
      ENSMUSP00000046324.7, ENSMUST00000038257.7
      Conserved Domains (2) summary
      cd03183
      Location:91216
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
      cd03050
      Location:378
      GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      75667676..75673253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513241.1XP_006513304.1  glutathione S-transferase theta-2 isoform X3

      Conserved Domains (1) summary
      cd03183
      Location:52177
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
    2. XM_006513240.1XP_006513303.1  glutathione S-transferase theta-2 isoform X2

      See identical proteins and their annotated locations for XP_006513303.1

      UniProtKB/Swiss-Prot
      Q61133
      Related
      ENSMUSP00000151239.2, ENSMUST00000220440.2
      Conserved Domains (2) summary
      cd03183
      Location:91216
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
      cd03050
      Location:378
      GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...
    3. XM_011243373.1XP_011241675.1  glutathione S-transferase theta-2 isoform X1

      Conserved Domains (2) summary
      cd03183
      Location:98223
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
      cd03050
      Location:385
      GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...
    4. XM_030244889.2XP_030100749.1  glutathione S-transferase theta-2 isoform X2

      Conserved Domains (2) summary
      cd03183
      Location:91216
      GST_C_Theta; C-terminal, alpha helical domain of Class Theta Glutathione S-transferases
      cd03050
      Location:378
      GST_N_Theta; GST_N family, Class Theta subfamily; composed of eukaryotic class Theta GSTs and bacterial dichloromethane (DCM) dehalogenase. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with ...
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