Raet1b retinoic acid early transcript beta [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Raet1bprovided by MGI
Official Full Name: retinoic acid early transcript betaprovided by MGI
Primary source: MGI:MGI:109432
See related: AllianceGenome:MGI:109432
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rae1b; RAE-1beta
Summary: Enables natural killer cell lectin-like receptor binding activity. Acts upstream of or within several processes, including positive regulation of immune response; positive regulation of leukocyte activation; and response to bacterium. Located in external side of plasma membrane. Is anchored component of external side of plasma membrane. Is expressed in several structures, including branchial arch; heart; liver; placenta; and spleen. Orthologous to several human genes including ULBP2 (UL16 binding protein 2); RAET1E (retinoic acid early transcript 1E); and RAET1G (retinoic acid early transcript 1G). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: not in current annotation release
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Genomic context

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Location:: chromosome: 10

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RAE-1B6 and H60 display high affinities for NKG2D with K(D) in the 20-30 nM range and k(off )in the 0.03s(-1) to 0.06s(-1) range (t(1/2) approximately 10-20s). They bind NKG2D with similar kinetics while sharing only 20% amino acid sequence identity.
Title: Ligands for murine NKG2D display heterogeneous binding behavior.
Rae-1 beta expression induces primary tumor rejection and triggers in vitro NK cell cytotoxicity and IFN-gamma secretion, but not proliferation.
Title: Cutting edge: tumor rejection mediated by NKG2D receptor-ligand interaction is dependent upon perforin.

Submit: New GeneRIF Correction

General gene information

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Markers

Raet1a (e-PCR), detects polymorphism
- UniSTS:257028

Raet1a (e-PCR), detects polymorphism
- UniSTS:256449

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables natural killer cell lectin-like receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables natural killer cell lectin-like receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	IBA Inferred from Biological aspect of Ancestor more info
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to exogenous dsRNA	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of immune response to tumor cell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of macrophage activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of natural killer cell activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of nitric oxide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of type II interferon production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within susceptibility to natural killer cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: retinoic acid early-inducible protein 1-beta

Names: RAE-1-beta; Rae-1 beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009017.1 → NP_033043.1 retinoic acid early-inducible protein 1-beta precursor

See identical proteins and their annotated locations for NP_033043.1

Status: PROVISIONAL

Source sequence(s)

D64161

UniProtKB/Swiss-Prot

A2RS95, O08603

Conserved Domains (1) summary

cl08246
Location:31 → 204

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2