Tcf7l1 transcription factor 7 like 1 (T cell specific, HMG box) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tcf7l1provided by MGI
Official Full Name: transcription factor 7 like 1 (T cell specific, HMG box)provided by MGI
Primary source: MGI:MGI:1202876
See related: Ensembl:ENSMUSG00000055799 AllianceGenome:MGI:1202876
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tcf3; Tcf-3; bHLHb21
Summary: Enables several functions, including DNA-binding transcription factor activity; beta-catenin binding activity; and chromatin binding activity. Acts upstream of or within several processes, including axial mesoderm morphogenesis; regulation of transcription, DNA-templated; and somatic stem cell population maintenance. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skin. Orthologous to human TCF7L1 (transcription factor 7 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in colon adult (RPKM 24.3), limb E14.5 (RPKM 24.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C1; 6 32.27 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (72603354..72766028, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (72626371..72789045, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TCF7L1 Controls the Differentiation of Tuft Cells in Mouse Small Intestine.
Title: TCF7L1 Controls the Differentiation of Tuft Cells in Mouse Small Intestine.
The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency.
Title: The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency.
TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state.
Title: TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state.
A beta-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells.
Title: A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells.
beta-catenin stimulates Tcf7l1 degradation through recruitment of casein kinase 2 in mouse embryonic stem cells.
Title: β-catenin stimulates Tcf7l1 degradation through recruitment of casein kinase 2 in mouse embryonic stem cells.
Tcf7l1 directly regulates cardiomyocyte differentiation in embryonic stem cells.
Title: Tcf7l1 directly regulates cardiomyocyte differentiation in embryonic stem cells.
Telomeric noncoding RNA maintains the pluripotency of murine embryonic stem cells serving as a responding mediator to the Wnt/beta-catenin signaling changes, eventually modulating the expression of TCF3, a well-established primary repressor for mESC stemness.
Title: Telomeric noncoding RNA promotes mouse embryonic stem cell self-renewal through inhibition of TCF3 activity.
Tcf7l1 defines the border between the neural crest and the prospective forebrain via restriction of the Wnt/beta-catenin signaling gradient.
Title: Tcf7l1 protects the anterior neural fold from adopting the neural crest fate.
report the identification of two independent missense variants in human TCF7L1, p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects
Title: Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans.
The authors find that downstream of glycogen synthase kinase 3 inhibition, elevated cMyc and beta-catenin act in parallel to reduce transcription and DNA binding, respectively, of the transcriptional repressor Tcf7l1.
Title: Convergence of cMyc and β-catenin on Tcf7l1 enables endoderm specification.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tcf3 (e-PCR), detects polymorphism
- UniSTS:507272

AJ223069 (e-PCR)
- UniSTS:179392

RH124429 (e-PCR)
- UniSTS:161251

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior/posterior axis specification, embryo	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axial mesoderm morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of somatic stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skin development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somatic stem cell population maintenance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of beta-catenin-TCF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription factor 7-like 1

Names: HMG box transcription factor 3; T-cell factor 3; transcription factor 3; transcription factor 7-like 2 (T-cell specific, HMG box)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079822.2 → NP_001073290.1 transcription factor 7-like 1 isoform 1

See identical proteins and their annotated locations for NP_001073290.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC125039, AC153613, BC128305

Consensus CDS

CCDS39517.1

UniProtKB/Swiss-Prot

O70450, O70573, Q9Z1J1

UniProtKB/TrEMBL

A1A549

Related

ENSMUSP00000109687.2, ENSMUST00000114053.9

Conserved Domains (2) summary

cd01388
Location:356 → 427

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:28 → 262

CTNNB1_binding; N-terminal CTNNB1 binding
NM_009332.3 → NP_033358.2 transcription factor 7-like 1 isoform 2

See identical proteins and their annotated locations for NP_033358.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.

Source sequence(s)

AC125039, AC153613, AF057691, AJ223069, AK052721

Consensus CDS

CCDS20245.1

UniProtKB/Swiss-Prot

O70450, O70573, Q9Z1J1

UniProtKB/TrEMBL

A1A550

Related

ENSMUSP00000069403.6, ENSMUST00000069536.12

Conserved Domains (2) summary

cd01388
Location:342 → 413

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam08347
Location:28 → 248

CTNNB1_binding; N-terminal CTNNB1 binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

72603354..72766028 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505882.2 → XP_006505945.1 transcription factor 7-like 1 isoform X1

Conserved Domains (2) summary

cd01388
Location:214 → 285

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam08347
Location:41 → 120

CTNNB1_binding; N-terminal CTNNB1 binding