Ppm1m protein phosphatase 1M [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppm1mprovided by MGI
Official Full Name: protein phosphatase 1Mprovided by MGI
Primary source: MGI:MGI:1915155
See related: Ensembl:ENSMUSG00000020253 AllianceGenome:MGI:1915155
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PP2Ceta; 2810423O19Rik
Summary: Enables manganese ion binding activity and phosphoprotein phosphatase activity. Acts upstream of or within protein dephosphorylation. Located in nucleus. Is expressed in brain; genitourinary system; heart; liver; and respiratory system. Orthologous to human PPM1M (protein phosphatase, Mg2+/Mn2+ dependent 1M). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in adrenal adult (RPKM 103.2), mammary gland adult (RPKM 42.3) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 57.46 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (106072152..106076432, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (106194953..106199233, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)
Endonuclease-mediated (1)

General gene information

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Markers

AW610647 (e-PCR)
- UniSTS:179969

RH126128 (e-PCR)
- UniSTS:162840

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein dephosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein phosphatase 1M

Names: PP2C-eta; PP2CE; protein phosphatase 2C eta; protein phosphatase 2C eta-2

NP_080723.3

EC 3.1.3.16

NP_945149.2

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026447.4 → NP_080723.3 protein phosphatase 1M isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

BC058248, BY202563

Consensus CDS

CCDS23472.2

UniProtKB/Swiss-Prot

E9Q2I3, Q8BU27, Q9CSD6, Q9CU88

UniProtKB/TrEMBL

A0A8I4Q8Y8

Related

ENSMUSP00000117908.2, ENSMUST00000140761.9

Conserved Domains (1) summary

cd00143
Location:109 → 452

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
NM_198931.3 → NP_945149.2 protein phosphatase 1M isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate first exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC164430, AY332616, BC058248

Consensus CDS

CCDS23471.1

UniProtKB/Swiss-Prot

E9Q2I3, Q8BU27, Q9CSD6, Q9CU88

UniProtKB/TrEMBL

F8WGF9

Related

ENSMUSP00000075607.6, ENSMUST00000076258.13

Conserved Domains (1) summary

cd00143
Location:53 → 396

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...