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    Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 20510, updated on 8-Jul-2021

    Summary

    Official Symbol
    Slc1a1provided by MGI
    Official Full Name
    solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1provided by MGI
    Primary source
    MGI:MGI:105083
    See related
    Ensembl:ENSMUSG00000024935
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EAA; MEAA; EAAC1; EAAC2; EAAT3; MEAAC1; D130048G10Rik
    Expression
    Biased expression in genital fat pad adult (RPKM 43.4), kidney adult (RPKM 33.9) and 13 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Slc1a1 in Genome Data Viewer
    Location:
    19; 19 C1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (28812535..28891360)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (28835135..28913960)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (28909656..28988450)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S15A, pseudogene 2 Neighboring gene predicted gene, 35922 Neighboring gene dynein family member Neighboring gene predicted gene, 52404 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene spermatogenesis associated 6 like Neighboring gene phospholipid phosphatase 6 Neighboring gene phytanoyl-CoA hydroxylase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables D-aspartate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-aspartate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-glutamate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables L-glutamate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables L-glutamate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables anion channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chloride transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutamate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glutamate:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glutamate:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables high-affinity glutamate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in D-aspartate import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in D-aspartate transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-aspartate import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-aspartate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-glutamate import ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within L-glutamate import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within L-glutamate import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in L-glutamate import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within L-glutamate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in L-glutamate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in activation of protein kinase B activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adult behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within amino acid transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to ammonium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to ammonium ion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to cocaine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to mercury ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular zinc ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular zinc ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chloride transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in conditioned place preference IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cysteine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cysteine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dopamine receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glutamate homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glutamate receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glutathione biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within glutathione metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glutathione metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in grooming behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within maintenance of blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in motor behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within motor neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within motor neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron death in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neurotransmitter receptor transport to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein targeting to membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to amphetamine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to anesthetic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to anesthetic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to axon injury IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to axon injury IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to axon injury IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to decreased oxygen levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to decreased oxygen levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to drug IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to morphine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to morphine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within retina layer formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retina layer formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within righting reflex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in superoxide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in zinc ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in asymmetric synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    located_in distal dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glial cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perisynaptic space ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in proximal dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic cleft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    excitatory amino acid transporter 3
    Names
    excitatory amino acid carrier 2
    excitatory amino-acid carrier 1
    glutamate transporter mEAAC2
    sodium-dependent glutamate/aspartate transporter 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009199.3NP_033225.1  excitatory amino acid transporter 3

      See identical proteins and their annotated locations for NP_033225.1

      Status: VALIDATED

      Source sequence(s)
      AC113961, AC163993
      Consensus CDS
      CCDS29727.1
      UniProtKB/Swiss-Prot
      P51906
      Related
      ENSMUSP00000025875.5, ENSMUST00000025875.5
      Conserved Domains (1) summary
      pfam00375
      Location:51464
      SDF; Sodium:dicarboxylate symporter family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      28812535..28891360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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