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    Rpl30 ribosomal protein L30 [ Mus musculus (house mouse) ]

    Gene ID: 19946, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rpl30provided by MGI
    Official Full Name
    ribosomal protein L30provided by MGI
    Primary source
    MGI:MGI:98037
    See related
    Ensembl:ENSMUSG00000058600 AllianceGenome:MGI:98037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable selenocysteine insertion sequence binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; cytoplasmic translation; and defense response to Gram-negative bacterium. Is active in postsynaptic density. Is expressed in brain. Human ortholog(s) of this gene implicated in herpes simplex. Orthologous to human RPL30 (ribosomal protein L30). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 355.7), liver E14 (RPKM 337.8) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 B3.1; 15 14.33 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (34440649..34443405, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (34440505..34443276, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene lysosomal-associated protein transmembrane 4B Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:34225853-34226040 Neighboring gene matrilin 2 Neighboring gene RIKEN cDNA 9430069I07 gene Neighboring gene STARR-seq mESC enhancer starr_38326 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:34372917-34373070 Neighboring gene predicted gene, 24523 Neighboring gene glutamate rich 5 Neighboring gene reactive intermediate imine deaminase A homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Three functional ribosomal protein genes are unlinked in mouse genome. Wiedemann LM, et al. Somat Cell Mol Genet, 1987 Jan. PMID 3468635
    2. Characterization of the expressed gene and several processed pseudogenes for the mouse ribosomal protein L30 gene family. Wiedemann LM, et al. Mol Cell Biol, 1984 Nov. PMID 6513928, Free PMC Article
    3. Chromosomal distribution of ribosomal protein genes in the mouse. D'Eustachio P, et al. Cell, 1981 May. PMID 7237550
    4. The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome. Feo S, et al. Genomics, 1992 May. PMID 1577483
    5. The Autism-Related Protein SETD5 Controls Neural Cell Proliferation through Epigenetic Regulation of rDNA Expression. Nakagawa T, et al. iScience, 2020 Apr 24. PMID 32299058, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC106425, MGC107559

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables selenocysteine insertion sequence binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in killing of cells of another organism ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in postsynaptic density EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    large ribosomal subunit protein eL30
    Names
    60S ribosomal protein L30

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163485.2 → NP_001156957.1  large ribosomal subunit protein eL30

      See identical proteins and their annotated locations for NP_001156957.1

      Status: VALIDATED

      Source sequence(s)
      AC126028
      Consensus CDS
      CCDS37057.1
      UniProtKB/Swiss-Prot
      P62889
      UniProtKB/TrEMBL
      Q497D7, Q58DZ3, Q5PR15
      Related
      ENSMUSP00000106014.2, ENSMUST00000079735.12
      Conserved Domains (1) summary
      PTZ00106
      Location:2 → 107
      PTZ00106; 60S ribosomal protein L30; Provisional

    2. NM_009083.5 → NP_033109.1  large ribosomal subunit protein eL30

      See identical proteins and their annotated locations for NP_033109.1

      Status: VALIDATED

      Source sequence(s)
      AC126028
      Consensus CDS
      CCDS37057.1
      UniProtKB/Swiss-Prot
      P62889
      UniProtKB/TrEMBL
      Q497D7, Q58DZ3, Q5PR15
      Related
      ENSMUSP00000009039.6, ENSMUST00000009039.6
      Conserved Domains (1) summary
      PTZ00106
      Location:2 → 107
      PTZ00106; 60S ribosomal protein L30; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      34440649..34443405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_001450.1: Suppressed sequence

      Description
      NG_001450.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62889.2 GenPept UniProtKB/Swiss-Prot:P62889

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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