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    Fbxl5 F-box and leucine-rich repeat protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 242960, updated on 23-Jun-2021

    Summary

    Official Symbol
    Fbxl5provided by MGI
    Official Full Name
    F-box and leucine-rich repeat protein 5provided by MGI
    Primary source
    MGI:MGI:2152883
    See related
    Ensembl:ENSMUSG00000039753
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fi; Fbl; Fbl4; Fir4
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 17.0), placenta adult (RPKM 16.2) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Fbxl5 in Genome Data Viewer
    Location:
    5; 5 B3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (43901958..43939529, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (43744618..43782149, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (44135857..44173388, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene C1q and tumor necrosis factor related protein 7 Neighboring gene predicted gene 15866 Neighboring gene coiled-coil and C2 domain containing 2A Neighboring gene predicted gene, 35762 Neighboring gene bone marrow stromal cell antigen 1 Neighboring gene predicted gene, 54296

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159963.1NP_001153435.1  F-box/LRR-repeat protein 5 isoform A

      See identical proteins and their annotated locations for NP_001153435.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).
      Source sequence(s)
      AK150664, AK159744, BY245949
      Consensus CDS
      CCDS51489.1
      UniProtKB/Swiss-Prot
      Q8C2S5
      Related
      ENSMUSP00000045792.10, ENSMUST00000047857.16
      Conserved Domains (4) summary
      cd09293
      Location:340404
      AMN1; Antagonist of mitotic exit network protein 1
      cd12109
      Location:7160
      Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
      sd00034
      Location:358384
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:205249
      F-box-like; F-box-like
    2. NM_178729.4NP_848844.1  F-box/LRR-repeat protein 5 isoform B

      See identical proteins and their annotated locations for NP_848844.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a different 3' terminus, compared to variant 1, which results in a protein (isoform B) with a shorter and distinct C-terminus, compared to isoform A.
      Source sequence(s)
      AK041497, BC113798, BY245949
      Consensus CDS
      CCDS19263.1
      UniProtKB/Swiss-Prot
      Q8C2S5
      Related
      ENSMUSP00000084733.5, ENSMUST00000087465.11
      Conserved Domains (4) summary
      cd09293
      Location:340404
      AMN1; Antagonist of mitotic exit network protein 1
      cd12109
      Location:7160
      Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
      sd00034
      Location:333357
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:205249
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      43901958..43939529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165123.1XP_036021016.1  F-box/LRR-repeat protein 5 isoform X1

      Conserved Domains (4) summary
      cd09293
      Location:340404
      AMN1; Antagonist of mitotic exit network protein 1
      cd12109
      Location:7160
      Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
      sd00034
      Location:358384
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:205249
      F-box-like

    RNA

    1. XR_004942514.1 RNA Sequence

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