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    Armcx1 armadillo repeat containing, X-linked 1 [ Mus musculus (house mouse) ]

    Gene ID: 78248, updated on 13-May-2024

    Summary

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    Official Symbol
    Armcx1provided by MGI
    Official Full Name
    armadillo repeat containing, X-linked 1provided by MGI
    Primary source
    MGI:MGI:1925498
    See related
    Ensembl:ENSMUSG00000033460 AllianceGenome:MGI:1925498
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ALEX1; 3010033I09Rik
    Summary
    Acts upstream of or within hematopoietic stem cell homeostasis. Predicted to be located in mitochondrial outer membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including eye; heart; and nervous system. Orthologous to human ARMCX1 (armadillo repeat containing X-linked 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 17.7), CNS E14 (RPKM 16.8) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    X E3; X 56.24 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (133618615..133623487)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (134717913..134721917)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA B230119M05 gene Neighboring gene 60S ribosomal protein L34 pseudogene Neighboring gene armadillo repeat containing, X-linked 4 Neighboring gene STARR-seq mESC enhancer starr_47966 Neighboring gene armadillo repeat containing, X-linked 7, pseudogene Neighboring gene armadillo repeat containing, X-linked 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Roles of syntaphilin and armadillo repeat-containing X-linked protein 1 in brain injury after experimental intracerebral hemorrhage. Xu X, et al. Neurosci Lett, 2023 Jul 13. PMID 37187340
    2. The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration. Cartoni R, et al. Neuron, 2016 Dec 21. PMID 28009275, Free PMC Article
    3. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. López-Doménech G, et al. Nat Commun, 2012 May 8. PMID 22569362
    4. Functional screen identifies regulators of murine hematopoietic stem cell repopulation. Holmfeldt P, et al. J Exp Med, 2016 Mar 7. PMID 26880577, Free PMC Article
    5. Transcriptomic analysis of the upper lip and primary palate development in mice. Cai S, et al. Front Genet, 2022. PMID 36685938, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Armcx1 Reduces Neurological Damage Via a Mitochondrial Transport Pathway Involving Miro1 After Traumatic Brain Injury.
      Title: Armcx1 Reduces Neurological Damage Via a Mitochondrial Transport Pathway Involving Miro1 After Traumatic Brain Injury.
    2. Armcx1 attenuates secondary brain injury in an experimental traumatic brain injury model in male mice by alleviating mitochondrial dysfunction and neuronal cell death.
      Title: Armcx1 attenuates secondary brain injury in an experimental traumatic brain injury model in male mice by alleviating mitochondrial dysfunction and neuronal cell death.
    3. Roles of syntaphilin and armadillo repeat-containing X-linked protein 1 in brain injury after experimental intracerebral hemorrhage.
      Title: Roles of syntaphilin and armadillo repeat-containing X-linked protein 1 in brain injury after experimental intracerebral hemorrhage.
    4. Armcx1 is upregulated after axotomy in a model with robust regeneration. Armcx1 overexpression enhances mitochondrial transport in adult retinal ganglion cells. Armcx1 also promotes both neuronal survival and axon regeneration after injury, and these effects depend on its mitochondrial localization.
      Title: The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    armadillo repeat-containing X-linked protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166377.1 → NP_001159849.1  armadillo repeat-containing X-linked protein 1

      See identical proteins and their annotated locations for NP_001159849.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.
      Source sequence(s)
      AK147002, BY129959, CF580092, CJ238664
      Consensus CDS
      CCDS30398.1
      UniProtKB/Swiss-Prot
      Q9CX83
      Related
      ENSMUSP00000108824.2, ENSMUST00000113199.8
      Conserved Domains (1) summary
      pfam04826
      Location:199 → 440
      Arm_2; Armadillo-like

    2. NM_001166378.1 → NP_001159850.1  armadillo repeat-containing X-linked protein 1

      See identical proteins and their annotated locations for NP_001159850.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate exons and uses a different splice site in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      BC026488, BY129959, CB209449, CF580092, CJ238664
      Consensus CDS
      CCDS30398.1
      UniProtKB/Swiss-Prot
      Q9CX83
      Related
      ENSMUSP00000108823.2, ENSMUST00000113198.8
      Conserved Domains (1) summary
      pfam04826
      Location:199 → 440
      Arm_2; Armadillo-like

    3. NM_001166379.1 → NP_001159851.1  armadillo repeat-containing X-linked protein 1

      See identical proteins and their annotated locations for NP_001159851.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      BB863367, BC026488, CF580092, CJ238664
      Consensus CDS
      CCDS30398.1
      UniProtKB/Swiss-Prot
      Q9CX83
      Related
      ENSMUSP00000053909.4, ENSMUST00000051256.10
      Conserved Domains (1) summary
      pfam04826
      Location:199 → 440
      Arm_2; Armadillo-like

    4. NM_001166380.1 → NP_001159852.1  armadillo repeat-containing X-linked protein 1

      See identical proteins and their annotated locations for NP_001159852.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon and uses a different splice site in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      BC068228, BY129959
      Consensus CDS
      CCDS30398.1
      UniProtKB/Swiss-Prot
      Q9CX83
      Related
      ENSMUSP00000108822.2, ENSMUST00000113197.2
      Conserved Domains (1) summary
      pfam04826
      Location:199 → 440
      Arm_2; Armadillo-like

    5. NM_030066.3 → NP_084342.1  armadillo repeat-containing X-linked protein 1

      See identical proteins and their annotated locations for NP_084342.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. All variants encode the same protein.
      Source sequence(s)
      BC068228, BY129959
      Consensus CDS
      CCDS30398.1
      UniProtKB/Swiss-Prot
      Q9CX83
      Related
      ENSMUSP00000043965.8, ENSMUST00000035748.14
      Conserved Domains (1) summary
      pfam04826
      Location:199 → 440
      Arm_2; Armadillo-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      133618615..133623487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162117.1 → XP_036018010.1  armadillo repeat-containing X-linked protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9CX83
      Conserved Domains (1) summary
      pfam04826
      Location:199 → 440
      Arm_2; Armadillo-like

    2. XM_006528625.3 → XP_006528688.1  armadillo repeat-containing X-linked protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006528688.1

      UniProtKB/Swiss-Prot
      Q9CX83
      Conserved Domains (1) summary
      pfam04826
      Location:199 → 440
      Arm_2; Armadillo-like

    3. XM_006528626.3 → XP_006528689.1  armadillo repeat-containing X-linked protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006528689.1

      UniProtKB/Swiss-Prot
      Q9CX83
      Related
      ENSMUSP00000108826.2, ENSMUST00000113201.8
      Conserved Domains (1) summary
      pfam04826
      Location:199 → 440
      Arm_2; Armadillo-like

    4. XM_036162118.1 → XP_036018011.1  armadillo repeat-containing X-linked protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9CX83
      Conserved Domains (1) summary
      pfam04826
      Location:199 → 440
      Arm_2; Armadillo-like

    5. XM_006528627.3 → XP_006528690.1  armadillo repeat-containing X-linked protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006528690.1

      UniProtKB/Swiss-Prot
      Q9CX83
      Conserved Domains (1) summary
      pfam04826
      Location:199 → 440
      Arm_2; Armadillo-like

    6. XM_006528624.3 → XP_006528687.1  armadillo repeat-containing X-linked protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006528687.1

      UniProtKB/Swiss-Prot
      Q9CX83
      Conserved Domains (1) summary
      pfam04826
      Location:199 → 440
      Arm_2; Armadillo-like
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CX83.1 GenPept UniProtKB/Swiss-Prot:Q9CX83

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