Prokr1 prokineticin receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prokr1provided by MGI
Official Full Name: prokineticin receptor 1provided by MGI
Primary source: MGI:MGI:1929676
See related: Ensembl:ENSMUSG00000049409 AllianceGenome:MGI:1929676
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pkr1; Gpr73; Pk-r1; EG-VEGFR1
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway and negative regulation of apoptotic process. Predicted to act upstream of or within circadian rhythm. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; eye; gut; metanephros; and reproductive system. Orthologous to human PROKR1 (prokineticin receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in genital fat pad adult (RPKM 3.3), liver E14.5 (RPKM 2.0) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D1; 6 38.28 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (87555568..87567741, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (87578586..87590762, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PROKR1 delivery by cell-derived vesicles restores the myogenic potential of Prokr1-deficient C2C12 myoblasts.
Title: PROKR1 delivery by cell-derived vesicles restores the myogenic potential of Prokr1-deficient C2C12 myoblasts.
Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to beta-arrestin 2.
Title: Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to β-arrestin 2.
Prokineticin receptor 1 ameliorates insulin resistance in skeletal muscle.
Title: Prokineticin receptor 1 ameliorates insulin resistance in skeletal muscle.
Upon high fat diet exposure, PKR1 (tcf-/-) mice displayed excessive fat deposition in the atrioventricular groove, perivascular area, and pericardium, which was accompanied by an impaired vascular network and cardiac dysfunction.
Title: Prokineticin receptor-1-dependent paracrine and autocrine pathways control cardiac tcf21(+) fibroblast progenitor cell transformation into adipocytes and vascular cells.
The study shows that PK2beta ligand, a splice variant of prokineticin 2, is able to modulate and drive signaling through prokineticin receptor 1.
Title: PK2β ligand, a splice variant of prokineticin 2, is able to modulate and drive signaling through PKR1 receptor.
The authors discovered that PKR1 regulates epicardial-mesenchymal transition (EMT) for epicardial-derived progenitor cell (EPDC), formation. This event affects at least three consequential steps during heart development: (i) EPDC and cardiomyocyte proliferation involved in thickening of an outer compact ventricular chamber wall, (ii) rhythmicity, (iii) formation of coronary circulation.
Title: Prokineticin receptor-1 signaling promotes Epicardial to Mesenchymal Transition during heart development.
These results establish PKR1 via NFATc3 as a crucial modifier of mesenchymal-epithelial transition processing to the development of nephron.
Title: Prokineticin receptor 1 is required for mesenchymal-epithelial transition in kidney development.
show that MRAP2 significantly and specifically inhibits PKR1 signaling.
Title: The Melanocortin Receptor Accessory Protein 2 promotes food intake through inhibition of the Prokineticin Receptor-1.
Data show that the prokineticins and their receptors PROK2, PKR1 and PKR2 contributes to altered sensitivity in diabetic neuropathy and its inhibition blocked both allodynia and inflammatory events underlying disease.
Title: Antagonism of the Prokineticin System Prevents and Reverses Allodynia and Inflammation in a Mouse Model of Diabetes.
These results suggest PKR1 to be a crucial player in the preadipocyte proliferation and differentiation.
Title: Prokineticin receptor 1 as a novel suppressor of preadipocyte proliferation and differentiation to control obesity.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (3) 1 citation

General gene information

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Markers

Prokr1 (e-PCR), detects polymorphism
- UniSTS:531376

Prokr1 (e-PCR), detects polymorphism
- UniSTS:528634

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables neuropeptide Y receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in circadian rhythm	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within circadian rhythm	TAS Traceable Author Statement more info	PubMed
involved_in coronary vasculature development	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prokineticin receptor 1

Names: G-protein coupled receptor 73

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355655.1 → NP_001342584.1 prokineticin receptor 1

Status: VALIDATED

Source sequence(s)

AC125171

Consensus CDS

CCDS20323.1

UniProtKB/Swiss-Prot

Q3U0M4, Q6PD11, Q9JKL1

Related

ENSMUSP00000144999.2, ENSMUST00000204682.3

Conserved Domains (1) summary

cd15204
Location:63 → 353

7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_021381.4 → NP_067356.2 prokineticin receptor 1

See identical proteins and their annotated locations for NP_067356.2

Status: VALIDATED

Source sequence(s)

AC125171, BC059003

Consensus CDS

CCDS20323.1

UniProtKB/Swiss-Prot

Q3U0M4, Q6PD11, Q9JKL1

Related

ENSMUSP00000059034.8, ENSMUST00000050887.9

Conserved Domains (1) summary

cd15204
Location:63 → 353

7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

87555568..87567741 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506433.5 → XP_006506496.1 prokineticin receptor 1 isoform X2

Conserved Domains (2) summary

cd14964
Location:18 → 48

7tm_GPCRs; TM helix 3 [structural motif]

cl28897
Location:1 → 234

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006506432.5 → XP_006506495.1 prokineticin receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006506495.1

UniProtKB/Swiss-Prot

Q3U0M4, Q6PD11, Q9JKL1

Conserved Domains (1) summary

cd15204
Location:63 → 353

7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors