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    H2bc4 H2B clustered histone 4 [ Mus musculus (house mouse) ]

    Gene ID: 68024, updated on 8-Feb-2024

    Summary

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    Official Symbol
    H2bc4provided by MGI
    Official Full Name
    H2B clustered histone 4provided by MGI
    Primary source
    MGI:MGI:1915274
    See related
    Ensembl:ENSMUSG00000018102 AllianceGenome:MGI:1915274
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H2bc6; H2bc8; H2bfs; Hist1h2bc; 2610022J01Rik
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Aug 2015]
    Expression
    Ubiquitous expression in colon adult (RPKM 339.7), small intestine adult (RPKM 307.1) and 28 other tissues See more
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    Genomic context

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    Location:
    13 A3.1; 13 9.87 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (23868182..23876805)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (23684199..23692480)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33968 Neighboring gene predicted gene, 22452 Neighboring gene STARR-positive B cell enhancer ABC_E384 Neighboring gene STARR-positive B cell enhancer ABC_E8514 Neighboring gene H2A clustered histone 6 Neighboring gene H1.6 linker histone, cluster member Neighboring gene H4 clustered histone 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Histone modifications associated with somatic hypermutation. Odegard VH, et al. Immunity, 2005 Jul. PMID 16039583
    2. Phosphorylation of histone H2B at DNA double-strand breaks. Fernandez-Capetillo O, et al. J Exp Med, 2004 Jun 21. PMID 15197225, Free PMC Article
    3. Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro. Ingram DA, et al. J Exp Med, 2001 Jul 2. PMID 11435472, Free PMC Article
    4. Histone H2B as a functionally important plasminogen receptor on macrophages. Das R, et al. Blood, 2007 Nov 15. PMID 17690254, Free PMC Article
    5. Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss. Scekic-Zahirovic J, et al. EMBO J, 2016 May 17. PMID 26951610, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histone H2B type 1-C/E/G
    Names
    H2B histone family, member S
    histone 1, H2bc
    histone cluster 1, H2bc

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290380.1 → NP_001277309.1  histone H2B type 1-C/E/G

      See identical proteins and their annotated locations for NP_001277309.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is intronless and differs from variant 1 in its 3' UTR which contains a palindromic termination sequence. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL592149
      Consensus CDS
      CCDS26357.1
      UniProtKB/Swiss-Prot
      Q6ZWY9
      UniProtKB/TrEMBL
      A0JLV3
      Conserved Domains (1) summary
      smart00427
      Location:28 → 124
      H2B; Histone H2B

    2. NM_023422.3 → NP_075911.2  histone H2B type 1-C/E/G

      See identical proteins and their annotated locations for NP_075911.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer, two exon transcript and contains a polyA signal and site. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK011516
      Consensus CDS
      CCDS26357.1
      UniProtKB/Swiss-Prot
      Q6ZWY9
      UniProtKB/TrEMBL
      A0JLV3
      Related
      ENSMUSP00000018246.5, ENSMUST00000018246.6
      Conserved Domains (1) summary
      smart00427
      Location:28 → 124
      H2B; Histone H2B

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      23868182..23876805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004938062.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZWY9.3 GenPept UniProtKB/Swiss-Prot:Q6ZWY9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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