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    Ralyl RALY RNA binding protein-like [ Mus musculus (house mouse) ]

    Gene ID: 76897, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ralylprovided by MGI
    Official Full Name
    RALY RNA binding protein-likeprovided by MGI
    Primary source
    MGI:MGI:1924147
    See related
    Ensembl:ENSMUSG00000039717 AllianceGenome:MGI:1924147
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0710005M24Rik
    Summary
    Predicted to enable RNA binding activity and identical protein binding activity. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in brain; spinal cord; and trigeminal ganglion. Orthologous to human RALYL (RALY RNA binding protein like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 5.5), cerebellum adult (RPKM 4.8) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ralyl in Genome Data Viewer
    Location:
    3 A1; 3 3.01 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (13535942..14247347)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (13471655..14182287)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06983 Neighboring gene STARR-seq mESC enhancer starr_06984 Neighboring gene death effector domain-containing pseudogene Neighboring gene predicted gene, 54190 Neighboring gene STARR-seq mESC enhancer starr_06985 Neighboring gene STARR-seq mESC enhancer starr_06986 Neighboring gene RIKEN cDNA 4930539N22 gene Neighboring gene predicted gene 2464 Neighboring gene STARR-seq mESC enhancer starr_06988 Neighboring gene high mobility group protein B1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_06989 Neighboring gene solute carrier family 25, member 37 pseudogene Neighboring gene ganglioside-induced differentiation-associated-protein 2 pseudogene Neighboring gene predicted gene, 41998 Neighboring gene STARR-seq mESC enhancer starr_06990 Neighboring gene predicted gene, 18661 Neighboring gene STARR-seq mESC enhancer starr_06991 Neighboring gene STARR-seq mESC enhancer starr_06992 Neighboring gene STARR-seq mESC enhancer starr_06993 Neighboring gene transforming, acidic coiled-coil containing protein 3 pseudogene Neighboring gene predicted gene, 18659 Neighboring gene STARR-seq mESC enhancer starr_06995 Neighboring gene STARR-seq mESC enhancer starr_06996 Neighboring gene predicted gene, 23112 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2. Wang X, et al. Nat Commun, 2021 Mar 9. PMID 33750796, Free PMC Article
    2. RALY RNA binding protein-like reduced expression is associated with poor prognosis in clear cell renal cell carcinoma. Cui ZW, et al. Asian Pac J Cancer Prev, 2012. PMID 22994768
    3. Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice. Delprato A, et al. Genes Brain Behav, 2015 Nov. PMID 26449520, Free PMC Article
    4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-beta2.
      Title: RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding Raly-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163328.1 → NP_001156800.1  RNA-binding Raly-like protein isoform a

      See identical proteins and their annotated locations for NP_001156800.1

      Status: VALIDATED

      Source sequence(s)
      AK032086, AK079659, CJ045018
      Consensus CDS
      CCDS84609.1
      UniProtKB/Swiss-Prot
      Q8BTF8, Q8BTF9, Q8BTG1
      Conserved Domains (2) summary
      cd12605
      Location:20 → 88
      RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
      pfam10779
      Location:201 → 246
      XhlA; Haemolysin XhlA

    2. NM_001163329.2 → NP_001156801.1  RNA-binding Raly-like protein isoform b

      See identical proteins and their annotated locations for NP_001156801.1

      Status: VALIDATED

      Source sequence(s)
      AC192090, AK032086, AK038465, BY252332
      Consensus CDS
      CCDS50863.1
      UniProtKB/Swiss-Prot
      Q8BTF8
      Related
      ENSMUSP00000104009.3, ENSMUST00000108372.4
      Conserved Domains (1) summary
      pfam10779
      Location:128 → 173
      XhlA; Haemolysin XhlA

    3. NM_001163330.2 → NP_001156802.1  RNA-binding Raly-like protein isoform c

      Status: VALIDATED

      Source sequence(s)
      AC192090, AK032086, AK038465, BY252332
      Consensus CDS
      CCDS50864.1
      UniProtKB/TrEMBL
      A0A0A6YXQ8, E9Q5X7
      Related
      ENSMUSP00000142094.2, ENSMUST00000192209.6

    4. NM_001357033.1 → NP_001343962.1  RNA-binding Raly-like protein isoform a

      Status: VALIDATED

      Source sequence(s)
      AC121588, AC161601, AK079659
      Consensus CDS
      CCDS84609.1
      UniProtKB/Swiss-Prot
      Q8BTF8, Q8BTF9, Q8BTG1
      Related
      ENSMUSP00000148795.2, ENSMUST00000193117.3
      Conserved Domains (2) summary
      cd12605
      Location:20 → 88
      RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
      pfam10779
      Location:201 → 246
      XhlA; Haemolysin XhlA

    5. NM_001357034.1 → NP_001343963.1  RNA-binding Raly-like protein isoform d

      Status: VALIDATED

      Source sequence(s)
      AC121588, AC147237, AC161601, AC192090
      Conserved Domains (1) summary
      cl17169
      Location:29 → 111
      RRM_SF; RNA recognition motif (RRM) superfamily

    6. NM_001357035.1 → NP_001343964.1  RNA-binding Raly-like protein isoform e

      Status: VALIDATED

      Source sequence(s)
      AC121588, AC147237, AC161601, AC192090
      Conserved Domains (1) summary
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. NM_001357036.1 → NP_001343965.1  RNA-binding Raly-like protein isoform f

      Status: VALIDATED

      Source sequence(s)
      AC121588, AC147237, AC161601, AC192090
      Conserved Domains (2) summary
      pfam10779
      Location:215 → 260
      XhlA; Haemolysin XhlA
      cl17169
      Location:29 → 111
      RRM_SF; RNA recognition motif (RRM) superfamily

    8. NM_178631.4 → NP_848746.1  RNA-binding Raly-like protein isoform a

      See identical proteins and their annotated locations for NP_848746.1

      Status: VALIDATED

      Source sequence(s)
      AK032086, AK079659, CJ045018
      Consensus CDS
      CCDS84609.1
      UniProtKB/Swiss-Prot
      Q8BTF8, Q8BTF9, Q8BTG1
      Conserved Domains (2) summary
      cd12605
      Location:20 → 88
      RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
      pfam10779
      Location:201 → 246
      XhlA; Haemolysin XhlA

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      13535942..14247347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163401.1 → XP_036019294.1  RNA-binding Raly-like protein isoform X9

      Conserved Domains (1) summary
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_036163397.1 → XP_036019290.1  RNA-binding Raly-like protein isoform X6

      Conserved Domains (1) summary
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_036163396.1 → XP_036019289.1  RNA-binding Raly-like protein isoform X6

      Conserved Domains (1) summary
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. XM_036163400.1 → XP_036019293.1  RNA-binding Raly-like protein isoform X9

      Conserved Domains (1) summary
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. XM_036163395.1 → XP_036019288.1  RNA-binding Raly-like protein isoform X4

      Conserved Domains (2) summary
      pfam10779
      Location:190 → 235
      XhlA; Haemolysin XhlA
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    6. XM_036163402.1 → XP_036019295.1  RNA-binding Raly-like protein isoform X10

      Conserved Domains (1) summary
      cl17169
      Location:15 → 97
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. XM_036163394.1 → XP_036019287.1  RNA-binding Raly-like protein isoform X1

      Conserved Domains (2) summary
      pfam10779
      Location:215 → 260
      XhlA; Haemolysin XhlA
      cl17169
      Location:29 → 111
      RRM_SF; RNA recognition motif (RRM) superfamily

    8. XM_036163398.1 → XP_036019291.1  RNA-binding Raly-like protein isoform X7

      Conserved Domains (1) summary
      cl17169
      Location:29 → 111
      RRM_SF; RNA recognition motif (RRM) superfamily

    9. XM_006530102.3 → XP_006530165.1  RNA-binding Raly-like protein isoform X5

      Conserved Domains (1) summary
      cd12605
      Location:34 → 102
      RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)

    10. XM_006530101.3 → XP_006530164.1  RNA-binding Raly-like protein isoform X2

      Conserved Domains (2) summary
      cd12605
      Location:34 → 102
      RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
      pfam10779
      Location:204 → 249
      XhlA; Haemolysin XhlA

    11. XM_036163399.1 → XP_036019292.1  RNA-binding Raly-like protein isoform X8

      Conserved Domains (1) summary
      cl17169
      Location:29 → 111
      RRM_SF; RNA recognition motif (RRM) superfamily

    12. XM_011248150.3 → XP_011246452.1  RNA-binding Raly-like protein isoform X3

      See identical proteins and their annotated locations for XP_011246452.1

      UniProtKB/Swiss-Prot
      Q8BTF8, Q8BTF9, Q8BTG1
      Conserved Domains (2) summary
      cd12605
      Location:20 → 88
      RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
      pfam10779
      Location:201 → 246
      XhlA; Haemolysin XhlA

    13. XM_030252881.2 → XP_030108741.1  RNA-binding Raly-like protein isoform X13

      UniProtKB/TrEMBL
      E9Q5X7

    14. XM_030252880.2 → XP_030108740.1  RNA-binding Raly-like protein isoform X12

    15. XM_030252879.2 → XP_030108739.1  RNA-binding Raly-like protein isoform X11

      Conserved Domains (1) summary
      pfam10779
      Location:117 → 162
      XhlA; Haemolysin XhlA
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BTF8.1 GenPept UniProtKB/Swiss-Prot:Q8BTF8

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