Cct7 chaperonin containing TCP1 subunit 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cct7provided by MGI
Official Full Name: chaperonin containing TCP1 subunit 7provided by MGI
Primary source: MGI:MGI:107184
See related: Ensembl:ENSMUSG00000030007 AllianceGenome:MGI:107184
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ccth; Cctz
Summary: Enables identical protein binding activity. Acts upstream of or within binding activity of sperm to zona pellucida and toxin transport. Located in cell body. Part of chaperonin-containing T-complex and zona pellucida receptor complex. Orthologous to human CCT7 (chaperonin containing TCP1 subunit 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 177.0), CNS E11.5 (RPKM 113.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C3; 6 37.46 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (85428487..85445459)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (85451505..85468477)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CCTeta is a novel soluble guanylyl cyclase-interacting protein [CCTeta]
Title: CCTeta, a novel soluble guanylyl cyclase-interacting protein.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124723 (e-PCR)
- UniSTS:161545

RH125529 (e-PCR)
- UniSTS:162345

CCT7 (e-PCR)
- UniSTS:510345

NoName (e-PCR)
- UniSTS:235479

UniSTS:235482 (e-PCR)
- UniSTS:235482

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein folding chaperone	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within binding of sperm to zona pellucida	IDA Inferred from Direct Assay more info	PubMed
involved_in chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of establishment of protein localization to telomere	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
part_of chaperonin-containing T-complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chaperonin-containing T-complex	IDA Inferred from Direct Assay more info	PubMed
part_of chaperonin-containing T-complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: T-complex protein 1 subunit eta

Names: CCT-eta; TCP-1-eta; chaperonin containing Tcp1, subunit 7 (eta); chaperonin containing t-complex subunit eta; chaperonin subunit 7 (eta)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007638.4 → NP_031664.3 T-complex protein 1 subunit eta

See identical proteins and their annotated locations for NP_031664.3

Status: VALIDATED

Source sequence(s)

AC155728, AK146902, AK150160, BQ951185

Consensus CDS

CCDS20295.1

UniProtKB/Swiss-Prot

P80313

UniProtKB/TrEMBL

Q3TET0, Q3THH8, Q3TIJ7, Q3TJN2, Q8C5Q5

Related

ENSMUSP00000032078.7, ENSMUST00000032078.9

Conserved Domains (1) summary

cd03340
Location:5 → 525

TCP1_eta; TCP-1 (CTT or eukaryotic type II) chaperonin family, eta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL), ...