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    Mpst mercaptopyruvate sulfurtransferase [ Mus musculus (house mouse) ]

    Gene ID: 246221, updated on 26-Mar-2024

    Summary

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    Official Symbol
    Mpstprovided by MGI
    Official Full Name
    mercaptopyruvate sulfurtransferaseprovided by MGI
    Primary source
    MGI:MGI:2179733
    See related
    Ensembl:ENSMUSG00000071711 AllianceGenome:MGI:2179733
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mst; 3MST
    Summary
    Enables 3-mercaptopyruvate sulfurtransferase activity. Involved in hydrogen sulfide biosynthetic process. Located in neuron projection. Orthologous to human MPST (mercaptopyruvate sulfurtransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 106.7), stomach adult (RPKM 95.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    15 E1; 15 37.47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78290918..78298213)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (78406712..78414015)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene ciliary microtubule inner protein 4 Neighboring gene STARR-seq mESC enhancer starr_39143 Neighboring gene thiosulfate sulfurtransferase, mitochondrial Neighboring gene predicted gene, 52185 Neighboring gene predicted gene, 36644 Neighboring gene predicted gene, 41355 Neighboring gene potassium channel tetramerisation domain containing 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity. Katsouda A, et al. J Exp Med, 2022 Jul 4. PMID 35616614, Free PMC Article
    2. Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation and Cellular Bioenergetics in Human Down Syndrome Fibroblasts. Panagaki T, et al. Biomolecules, 2020 Apr 23. PMID 32340322, Free PMC Article
    3. The protective role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H(2)S) pathway against experimental osteoarthritis. Nasi S, et al. Arthritis Res Ther, 2020 Mar 17. PMID 32183900, Free PMC Article
    4. Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells. Augsburger F, et al. Biomolecules, 2020 Mar 13. PMID 32183148, Free PMC Article
    5. Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase. Peleli M, et al. Biochem Pharmacol, 2020 Jun. PMID 32027885, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation and Cellular Bioenergetics in Human Down Syndrome Fibroblasts.
      Title: Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation and Cellular Bioenergetics in Human Down Syndrome Fibroblasts.
    2. Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells.
      Title: Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells.
    3. The protective role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H2S) pathway against experimental osteoarthritis.
      Title: The protective role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H(2)S) pathway against experimental osteoarthritis.
    4. Thioredoxin regulates human mercaptopyruvate sulfurtransferase at physiologically-relevant concentrations.
      Title: Thioredoxin regulates human mercaptopyruvate sulfurtransferase at physiologically-relevant concentrations.
    5. Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase.
      Title: Cardiovascular phenotype of mice lacking 3-mercaptopyruvate sulfurtransferase.
    6. the findings of this study indicate that a deficiency in 3MST does not significantly affect endotoxemia, while a deficiency in CBS or CSE slightly ameliorates the outcome of LPS-induced endotoxemia in vivo.
      Title: Effect of endotoxemia in mice genetically deficient in cystathionine-γ-lyase, cystathionine-β-synthase or 3-mercaptopyruvate sulfurtransferase.
    7. Up-regulation of 3-MST was located in living neurons and followed neuronal autophagy after traumatic brain injury.
      Title: Upregulation of 3-MST Relates to Neuronal Autophagy After Traumatic Brain Injury in Mice.
    8. H2S3 and H2S are produced in the brain by 3-mercaptopyruvate sulfurtransferase.
      Title: Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain.
    9. 3-Mercaptopyruvate sulphurtransferase and not cystathionine gamma-lyase is the primary regulator of coronary artery hydrogen sulfide production and function.
      Title: MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary artery.
    10. behavioral abnormality in MST-KO mice is caused by MST function defects such as an antioxidant insufficiency or a new transducer, H2S (or HS(-)) and/or SOx deficiency.
      Title: Antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase-knockout mice exhibit increased anxiety-like behaviors: a model for human mercaptolactate-cysteine disulfiduria.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-mercaptopyruvate sulfurtransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-mercaptopyruvate sulfurtransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-mercaptopyruvate sulfurtransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfurtransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiosulfate sulfurtransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiosulfate sulfurtransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in hydrogen sulfide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in kidney development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in liver development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transsulfuration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    3-mercaptopyruvate sulfurtransferase
    NP_001155964.1
    NP_001155965.1
    NP_001402986.1
    NP_001402987.1
    NP_001402988.1
    NP_001402989.1
    NP_001402990.1
    NP_619611.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162492.2 → NP_001155964.1  3-mercaptopyruvate sulfurtransferase

      See identical proteins and their annotated locations for NP_001155964.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL583893, AL590144
      Consensus CDS
      CCDS27615.1
      UniProtKB/Swiss-Prot
      Q3UW66, Q505N7, Q99J99
      Related
      ENSMUSP00000128075.2, ENSMUST00000169133.8
      Conserved Domains (1) summary
      COG2897
      Location:1 → 279
      SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]

    2. NM_001162493.2 → NP_001155965.1  3-mercaptopyruvate sulfurtransferase

      See identical proteins and their annotated locations for NP_001155965.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL583893, AL590144
      Consensus CDS
      CCDS27615.1
      UniProtKB/Swiss-Prot
      Q3UW66, Q505N7, Q99J99
      Related
      ENSMUSP00000130493.2, ENSMUST00000167140.8
      Conserved Domains (1) summary
      COG2897
      Location:1 → 279
      SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]

    3. NM_001416057.1 → NP_001402986.1  3-mercaptopyruvate sulfurtransferase

      Status: VALIDATED

      Source sequence(s)
      AL583893, AL590144
      UniProtKB/Swiss-Prot
      Q3UW66, Q505N7, Q99J99

    4. NM_001416058.1 → NP_001402987.1  3-mercaptopyruvate sulfurtransferase

      Status: VALIDATED

      Source sequence(s)
      AL583893, AL590144
      UniProtKB/Swiss-Prot
      Q3UW66, Q505N7, Q99J99

    5. NM_001416059.1 → NP_001402988.1  3-mercaptopyruvate sulfurtransferase

      Status: VALIDATED

      Source sequence(s)
      AL583893, AL590144
      UniProtKB/Swiss-Prot
      Q3UW66, Q505N7, Q99J99

    6. NM_001416060.1 → NP_001402989.1  3-mercaptopyruvate sulfurtransferase

      Status: VALIDATED

      Source sequence(s)
      AL583893, AL590144
      UniProtKB/Swiss-Prot
      Q3UW66, Q505N7, Q99J99

    7. NM_001416061.1 → NP_001402990.1  3-mercaptopyruvate sulfurtransferase

      Status: VALIDATED

      Source sequence(s)
      AL583893, AL590144
      UniProtKB/Swiss-Prot
      Q3UW66, Q505N7, Q99J99

    8. NM_138670.4 → NP_619611.3  3-mercaptopyruvate sulfurtransferase

      See identical proteins and their annotated locations for NP_619611.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL583893, AL590144
      Consensus CDS
      CCDS27615.1
      UniProtKB/Swiss-Prot
      Q3UW66, Q505N7, Q99J99
      Related
      ENSMUSP00000043061.7, ENSMUST00000043865.8
      Conserved Domains (1) summary
      COG2897
      Location:1 → 279
      SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      78290918..78298213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99J99.4 GenPept UniProtKB/Swiss-Prot:Q99J99

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