Taar4 trace amine-associated receptor 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Taar4provided by MGI
Official Full Name: trace amine-associated receptor 4provided by MGI
Primary source: MGI:MGI:2685072
See related: Ensembl:ENSMUSG00000069707 AllianceGenome:MGI:2685072
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ta2; Gm226; taR-4
Summary: Enables 2-phenylethylamine receptor activity. Involved in behavioral fear response; chemosensory behavior; and sensory perception of chemical stimulus. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in Grueneberg ganglion; nasal septum; and olfactory epithelium. Orthologous to human TAAR4P (trace amine associated receptor 4, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 10 A4; 10 11.4 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (23836392..23837435)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (23960494..23961537)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TAAR3, TAAR4 and TAAR5 are evolutionarily conserved and determine the sensitivity to a class of biologically relevant chemicals
Title: Single olfactory receptors set odor detection thresholds.
In mouse, TAAR4 is encoded by adjacent genes and localize to adjacent glomeruli, yet mediate opposing behaviors.
Title: Trace amine-associated receptors: ligands, neural circuits, and behaviors.
Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines.
Title: A second class of chemosensory receptors in the olfactory epithelium.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:487466

Taar4 (e-PCR), detects polymorphism
- UniSTS:516838

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2-phenylethylamine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2-phenylethylamine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables 2-phenylethylamine receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled amine receptor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables trace-amine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables trace-amine receptor activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	RCA inferred from Reviewed Computational Analysis more info	PubMed
acts_upstream_of_or_within behavior	IEA Inferred from Electronic Annotation more info
involved_in behavioral fear response	IBA Inferred from Biological aspect of Ancestor more info
involved_in behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemosensory behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of chemical stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory perception of chemical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: trace amine-associated receptor 4

Names: 2-phenylethylamine receptor; mTaar4; trace amine receptor 2; trace amine receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008499.1 → NP_001008499.1 trace amine-associated receptor 4

See identical proteins and their annotated locations for NP_001008499.1

Status: PROVISIONAL

Source sequence(s)

AY702328

Consensus CDS

CCDS23737.1

UniProtKB/Swiss-Prot

Q5QD15

UniProtKB/TrEMBL

A4FUU0

Related

ENSMUSP00000090330.2, ENSMUST00000092660.2

Conserved Domains (2) summary

pfam00001
Location:50 → 313

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:34 → 170

7tm_4; Olfactory receptor