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    Mmp11 matrix metallopeptidase 11 [ Mus musculus (house mouse) ]

    Gene ID: 17385, updated on 22-Aug-2021

    Summary

    Official Symbol
    Mmp11provided by MGI
    Official Full Name
    matrix metallopeptidase 11provided by MGI
    Primary source
    MGI:MGI:97008
    See related
    Ensembl:ENSMUSG00000000901
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ST; ST3; SL-3; Stmy; Stmy3; MMP-11
    Summary
    This gene encodes a member of the matrix metalloproteinase family of endopeptidases that are involved in remodeling extracellular matrix during, for example, embryonic development and tumor progression. The encoded protein undergoes post-translational proteolytic processing by furin endopeptidase to form an active enzyme. Subcutaneous introduction of cells expressing the encoded protein into nude mice results in increased tumor incidence. Mice lacking the encoded protein exhibit a decreased incidence of chemically-induced tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
    Expression
    Biased expression in ovary adult (RPKM 143.8), limb E14.5 (RPKM 82.7) and 10 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Mmp11 in Genome Data Viewer
    Location:
    10 C1; 10 38.62 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75759056..75768336, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75923221..75932502, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (75385969..75395208, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene Der1-like domain family, member 3 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10 Neighboring gene predicted gene 867 Neighboring gene pre-B lymphocyte gene 3 Neighboring gene 60S ribosomal protein L27 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metallopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular matrix IC
    Inferred by Curator
    more info
    PubMed 
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    stromelysin-3
    Names
    matrix metalloproteinase 11
    stromelysin 3
    NP_001293113.1
    NP_032632.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001306184.1NP_001293113.1  stromelysin-3 preproprotein

      See identical proteins and their annotated locations for NP_001293113.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK165778, BY100700, CD742452
      Consensus CDS
      CCDS23937.1
      UniProtKB/Swiss-Prot
      Q02853
      UniProtKB/TrEMBL
      Q3UQT3
      Related
      ENSMUSP00000112940.2, ENSMUST00000120281.8
      Conserved Domains (3) summary
      cd00094
      Location:295484
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:108262
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:108262
      Peptidase_M10; Matrixin
    2. NM_008606.3NP_032632.1  stromelysin-3 preproprotein

      See identical proteins and their annotated locations for NP_032632.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK142169, BY100700, CD742452
      Consensus CDS
      CCDS23937.1
      UniProtKB/Swiss-Prot
      Q02853
      UniProtKB/TrEMBL
      Q3UQT3
      Related
      ENSMUSP00000000924.7, ENSMUST00000000924.13
      Conserved Domains (3) summary
      cd00094
      Location:295484
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:108262
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:108262
      Peptidase_M10; Matrixin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      75759056..75768336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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