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    Nkd2 naked cuticle 2 [ Mus musculus (house mouse) ]

    Gene ID: 72293, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Nkd2provided by MGI
    Official Full Name
    naked cuticle 2provided by MGI
    Primary source
    MGI:MGI:1919543
    See related
    Ensembl:ENSMUSG00000021567 AllianceGenome:MGI:1919543
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mNkd2; 2210403L10Rik
    Summary
    Predicted to enable enzyme binding activity; growth factor binding activity; and myosin heavy chain binding activity. Predicted to be involved in several processes, including Golgi vesicle fusion to target membrane; positive regulation of protein localization to plasma membrane; and positive regulation of proteolysis. Predicted to act upstream of or within Wnt signaling pathway and exocytosis. Predicted to be located in basolateral plasma membrane; exocytic vesicle; and lateral plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; nasal cavity epithelium; paraxial mesenchyme; and reproductive system. Orthologous to human NKD2 (NKD inhibitor of WNT signaling pathway 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 24.2), limb E14.5 (RPKM 15.3) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nkd2 in Genome Data Viewer
    Location:
    13 C1; 13 40.15 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (73966653..73995750, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (73818534..73847631, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 19 Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 19, opposite strand Neighboring gene solute carrier family 12, member 7 Neighboring gene STARR-seq mESC enhancer starr_34997 Neighboring gene STARR-seq mESC enhancer starr_35002 Neighboring gene predicted pseudogene 8062 Neighboring gene predicted gene, 30303 Neighboring gene predicted gene, 30432

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse naked cuticle 2 (mNkd2) as a direct transcriptional target of Hoxc8 in vivo. Lei H, et al. J Exp Zool A Ecol Genet Physiol, 2007 Jan 1. PMID 17094106
    2. NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma. Zhao S, et al. Oncogene, 2015 Sep 24. PMID 25579177, Free PMC Article
    3. Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2. Zhang S, et al. Mol Cell Biol, 2007 Jun. PMID 17438140, Free PMC Article
    4. Epha1 is a cell-surface marker for the neuromesodermal competent population. de Lemos L, et al. Development, 2022 Mar 15. PMID 35299237
    5. Vertebrate proteins related to Drosophila Naked Cuticle bind Dishevelled and antagonize Wnt signaling. Wharton KA Jr, et al. Dev Biol, 2001 Jun 1. PMID 11356022

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. studies provide compelling evidence that downregulation of NKD2 expression and alterations in associated regulated pathways have a significant role in driving OS tumor growth and metastasis
      Title: NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma.
    2. Mouse naked cuticle 2 (mNkd2) is a direct transcriptional target of Hoxc8 in vivo.
      Title: Mouse naked cuticle 2 (mNkd2) as a direct transcriptional target of Hoxc8 in vivo.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables growth factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables myosin heavy chain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi vesicle fusion to target membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in exocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein naked cuticle homolog 2
    Names
    naked cuticle 1 homolog
    naked cuticle 2 homolog
    naked-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347535.1 → NP_001334464.1  protein naked cuticle homolog 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AK081904, AW124327, BY087192, CT030152
      Consensus CDS
      CCDS84036.1
      UniProtKB/Swiss-Prot
      Q8VE28
      Related
      ENSMUSP00000113794.2, ENSMUST00000118096.2

    2. NM_028186.5 → NP_082462.3  protein naked cuticle homolog 2 isoform a

      See identical proteins and their annotated locations for NP_082462.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK146667, AW124327, BY087192, CT030152
      Consensus CDS
      CCDS26636.1
      UniProtKB/Swiss-Prot
      Q3TYU5, Q3UM34, Q8C4J8, Q8VE28, Q91Y45, Q9D7U9
      Related
      ENSMUSP00000022051.8, ENSMUST00000022051.14

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      73966653..73995750 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VE28.2 GenPept UniProtKB/Swiss-Prot:Q8VE28

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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