Rasgrp1 RAS guanyl releasing protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rasgrp1provided by MGI
Official Full Name: RAS guanyl releasing protein 1provided by MGI
Primary source: MGI:MGI:1314635
See related: Ensembl:ENSMUSG00000027347 AllianceGenome:MGI:1314635
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rasgrp; calDAG-GEFII
Summary: Predicted to enable several functions, including cation binding activity; diacylglycerol binding activity; and guanyl-nucleotide exchange factor activity. Involved in positive regulation of T cell differentiation in thymus and positive regulation of natural killer cell differentiation. Acts upstream of or within several processes, including activation of GTPase activity; mast cell degranulation; and regulation of phosphatidylinositol 3-kinase signaling. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Is expressed in brain; olfactory epithelium; olfactory lobe; and telencephalon mantle layer. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in immunodeficiency 64. Orthologous to human RASGRP1 (RAS guanyl releasing protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 49.5), cortex adult (RPKM 48.8) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 59.19 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (117110464..117173358, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (117279983..117342877, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RASGRP1 targeted by H3K27me3 regulates myoblast proliferation and differentiation in mice and pigs.
Title: RASGRP1 targeted by H3K27me3 regulates myoblast proliferation and differentiation in mice and pigs.
Cutting Edge: Induced Loss of Rasgrp1 in Peripheral CD4+ T Cells of Conditional Rasgrp1-Deficient Mice Reveals an Essential Role for Rasgrp1 in TCR/CD28-Induced Ras-MAPK Signaling.
Title: Cutting Edge: Induced Loss of Rasgrp1 in Peripheral CD4+ T Cells of Conditional Rasgrp1-Deficient Mice Reveals an Essential Role for Rasgrp1 in TCR/CD28-Induced Ras-MAPK Signaling.
RasGRP1 promotes the acute inflammatory response and restricts inflammation-associated cancer cell growth.
Title: RasGRP1 promotes the acute inflammatory response and restricts inflammation-associated cancer cell growth.
Nras Q61R/+ and Kras-/- cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors.
Title: Nras Q61R/+ and Kras-/- cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors.
Nurr1 performs its anti-inflammatory function by regulating RasGRP1 expression in neuro-inflammation.
Title: Nurr1 performs its anti-inflammatory function by regulating RasGRP1 expression in neuro-inflammation.
Increased baseline RASGRP1 signals enhance stem cell fitness during native hematopoiesis.
Title: Increased baseline RASGRP1 signals enhance stem cell fitness during native hematopoiesis.
RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer.
Title: RasGRP1 is a potential biomarker to stratify anti-EGFR therapy response in colorectal cancer.
this study indicates a mechanism for the association of RasGRP1 deficiency with predispostion to infection in the loss of a particular B1a lymphocyte subpopulation.
Title: Impairment of PD-L2 positive B1a cells enhances susceptibility to sepsis in RasGRP1-deficient mice.
this study shows that TGF-beta suppresses RasGRP1 expression and supports regulatory T cell resistance against p53-induced CD28-dependent T-cell apoptosis
Title: TGF-β suppresses RasGRP1 expression and supports regulatory T cell resistance against p53-induced CD28-dependent T-cell apoptosis.
guanine nucleotide exchange factor RasGRP1 inhibited Rhes-mediated control of striatal motor activity in mice. RasGRP1 stabilized Rhes, increasing its synaptic accumulation in the striatum.
Title: RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1)
Targeted (3) 1 citation
Chemically induced (ENU) (7)
Endonuclease-mediated (3)

General gene information

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Markers

Rasgrp1 (e-PCR), detects polymorphism
- UniSTS:508519

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables diacylglycerol binding	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell activation	ISO Inferred from Sequence Orthology more info
involved_in B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
involved_in T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within activation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mast cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mast cell degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in natural killer cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of natural killer cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within secretory granule localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vesicle transport along microtubule	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: RAS guanyl-releasing protein 1

Names: calcium and DAG-regulated guanine nucleotide exchange factor II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011246.3 → NP_035376.1 RAS guanyl-releasing protein 1

See identical proteins and their annotated locations for NP_035376.1

Status: VALIDATED

Source sequence(s)

BC057341, BE991595

Consensus CDS

CCDS16572.1

UniProtKB/Swiss-Prot

Q3URH0, Q3V401, Q8BQP6, Q9Z1S3

UniProtKB/TrEMBL

G3UYC3

Related

ENSMUSP00000099593.5, ENSMUST00000102534.11

Conserved Domains (5) summary

smart00147
Location:201 → 437

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:54 → 176

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd00051
Location:474 → 521

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00130
Location:542 → 591

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

pfam13499
Location:478 → 526

EF-hand_7; EF-hand domain pair